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Article: Neural activity associated with cognitive regulation in heroin users: A fMRI study

TitleNeural activity associated with cognitive regulation in heroin users: A fMRI study
Authors
KeywordsAddiction
Cognitive regulation
fMRI
Heroin
Impulsive behavior
Inhibition
Opioid
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2005, v. 382 n. 3, p. 211-216 How to Cite?
AbstractPrevious research has found heroin addicts to be impulsive. This study employed functional magnetic resonance imaging technology to investigate the differences between heroin addicts and normal controls in neural activity associated with cognitive regulation of behavior. Twenty-one Chinese men participated in this study, 11 of whom were newly admitted heroin-addicted patients and 10 of whom were healthy volunteers. In the experimental task, the subjects were required to first identify the correct directions of arrowheads and then give the opposite answers. Behaviorally, the heroin-dependent patients took a much shorter time to complete the more demanding second part of the task but committed more errors than the normal controls. This pattern of behavior, characteristic of people who are disinhibited and who tend to be impulsive, was consistent with previous reports of impulsivity observed in people who have abused heroin. The neural activity of the patients that was associated with performing the experimental task of cognitive regulation was different to that of the normal controls in terms of the pattern of prefrontal activation, the attenuation of activity in the anterior cingulate, and the additional recruitment of the right inferior parietal region. This study is the first that seeks to understand the neural activity associated with impulsive behavior in people who abuse heroin. The pattern of imaging data obtained resembled the pattern of data observed in immature brains attempting to exercise cognitive control of behavior. Further theoretical and clinical implications of the findings are discussed. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89385
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorZhou, WHen_HK
dc.contributor.authorLuo, XJen_HK
dc.contributor.authorYuen, KSLen_HK
dc.contributor.authorRuan, XZen_HK
dc.contributor.authorWeng, XCen_HK
dc.date.accessioned2010-09-06T09:56:21Z-
dc.date.available2010-09-06T09:56:21Z-
dc.date.issued2005en_HK
dc.identifier.citationNeuroscience Letters, 2005, v. 382 n. 3, p. 211-216en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89385-
dc.description.abstractPrevious research has found heroin addicts to be impulsive. This study employed functional magnetic resonance imaging technology to investigate the differences between heroin addicts and normal controls in neural activity associated with cognitive regulation of behavior. Twenty-one Chinese men participated in this study, 11 of whom were newly admitted heroin-addicted patients and 10 of whom were healthy volunteers. In the experimental task, the subjects were required to first identify the correct directions of arrowheads and then give the opposite answers. Behaviorally, the heroin-dependent patients took a much shorter time to complete the more demanding second part of the task but committed more errors than the normal controls. This pattern of behavior, characteristic of people who are disinhibited and who tend to be impulsive, was consistent with previous reports of impulsivity observed in people who have abused heroin. The neural activity of the patients that was associated with performing the experimental task of cognitive regulation was different to that of the normal controls in terms of the pattern of prefrontal activation, the attenuation of activity in the anterior cingulate, and the additional recruitment of the right inferior parietal region. This study is the first that seeks to understand the neural activity associated with impulsive behavior in people who abuse heroin. The pattern of imaging data obtained resembled the pattern of data observed in immature brains attempting to exercise cognitive control of behavior. Further theoretical and clinical implications of the findings are discussed. © 2005 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAddictionen_HK
dc.subjectCognitive regulationen_HK
dc.subjectfMRIen_HK
dc.subjectHeroinen_HK
dc.subjectImpulsive behavioren_HK
dc.subjectInhibitionen_HK
dc.subjectOpioiden_HK
dc.titleNeural activity associated with cognitive regulation in heroin users: A fMRI studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=382&spage=211&epage=216&date=2005&atitle=Neural+activity+associated+with+cognitive+regulation+in+heroin+users:+a+fMRI+studyen_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neulet.2005.03.053en_HK
dc.identifier.pmid15925092-
dc.identifier.scopuseid_2-s2.0-19544370891en_HK
dc.identifier.hkuros102203en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-19544370891&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume382en_HK
dc.identifier.issue3en_HK
dc.identifier.spage211en_HK
dc.identifier.epage216en_HK
dc.identifier.isiWOS:000230065800003-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridZhou, WH=7404515453en_HK
dc.identifier.scopusauthoridLuo, XJ=26660594700en_HK
dc.identifier.scopusauthoridYuen, KSL=7202333396en_HK
dc.identifier.scopusauthoridRuan, XZ=8588890000en_HK
dc.identifier.scopusauthoridWeng, XC=7102594100en_HK

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