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Article: Sex-related differences in neural activity during risk taking: An fMRI study

TitleSex-related differences in neural activity during risk taking: An fMRI study
Authors
KeywordsInsula
Neuroimaging
Orbitofrontal cortex
Risk taking
Sex differences
Issue Date2009
PublisherOxford University Press. The Journal's web site is located at http://cercor.oxfordjournals.org/
Citation
Cerebral Cortex, 2009, v. 19 n. 6, p. 1303-1312 How to Cite?
AbstractThis study explored sex effects on the process of risk-taking. We observed that the female participants (n = 10) showed stronger activation in the right insula and bilateral orbitofrontal cortex (OFC) than did the male participants (n = 12) while they were performing in the Risky-Gains task. The female participants also showed stronger activations in the precentral, postcentral, and paracentral regions after receiving punishment feedback. In addition, the strength of neural activity in the insula correlated with the rate of risky behaviors for the female participants but not for the male participants. Similarly, the percent signal changes in the right OFC correlated negatively with the rate of selecting risky choices for the female group. These findings strongly suggest a sex-related influence modulating brain activity during risk-taking tasks. When taking the same level of risk, relative to men, women tend to engage in more neural processing involving the insula and the OFC to update and valuate possible uncertainty associated with risk-taking decision making. These results are consistent with the value-based decision-making model and offer insights into the possible neural mechanisms underlying the different risk-taking attitudes of men and women.
Persistent Identifierhttp://hdl.handle.net/10722/89357
ISSN
2015 Impact Factor: 8.285
2015 SCImago Journal Rankings: 4.827
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Research Output Prize of The University of Hong Kong
Collaboration Research Award of the national Natural Science Foundation of China30828012
Hong Kong Polytechnic University
Funding Information:

This project was supported by the Research Output Prize of The University of Hong Kong, Collaboration Research Award of the national Natural Science Foundation of China (30828012), and the Niche Area Research Grant on "Applied Cognitive Neuroscience and Neuroplasticity'' of The Hong Kong Polytechnic University.

References

 

DC FieldValueLanguage
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorChan, CCHen_HK
dc.contributor.authorLeung, AWSen_HK
dc.contributor.authorFox, PTen_HK
dc.contributor.authorGao, JHen_HK
dc.date.accessioned2010-09-06T09:55:59Z-
dc.date.available2010-09-06T09:55:59Z-
dc.date.issued2009en_HK
dc.identifier.citationCerebral Cortex, 2009, v. 19 n. 6, p. 1303-1312en_HK
dc.identifier.issn1047-3211en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89357-
dc.description.abstractThis study explored sex effects on the process of risk-taking. We observed that the female participants (n = 10) showed stronger activation in the right insula and bilateral orbitofrontal cortex (OFC) than did the male participants (n = 12) while they were performing in the Risky-Gains task. The female participants also showed stronger activations in the precentral, postcentral, and paracentral regions after receiving punishment feedback. In addition, the strength of neural activity in the insula correlated with the rate of risky behaviors for the female participants but not for the male participants. Similarly, the percent signal changes in the right OFC correlated negatively with the rate of selecting risky choices for the female group. These findings strongly suggest a sex-related influence modulating brain activity during risk-taking tasks. When taking the same level of risk, relative to men, women tend to engage in more neural processing involving the insula and the OFC to update and valuate possible uncertainty associated with risk-taking decision making. These results are consistent with the value-based decision-making model and offer insights into the possible neural mechanisms underlying the different risk-taking attitudes of men and women.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://cercor.oxfordjournals.org/en_HK
dc.relation.ispartofCerebral Cortexen_HK
dc.rightsCerebral Cortex. Copyright © Oxford University Press.en_HK
dc.subjectInsulaen_HK
dc.subjectNeuroimagingen_HK
dc.subjectOrbitofrontal cortexen_HK
dc.subjectRisk takingen_HK
dc.subjectSex differencesen_HK
dc.titleSex-related differences in neural activity during risk taking: An fMRI studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1047-3211&volume=19&spage=1303&epage=1312&date=2009&atitle=Sex-related+differences+in+neural+activity+during+risk+taking:+An+fMRI+study.en_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/cercor/bhn172en_HK
dc.identifier.pmid18842666-
dc.identifier.pmcidPMC2677650-
dc.identifier.scopuseid_2-s2.0-66549108710en_HK
dc.identifier.hkuros158106en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-66549108710&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1303en_HK
dc.identifier.epage1312en_HK
dc.identifier.eissn1460-2199-
dc.identifier.isiWOS:000265951000006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridChan, CCH=16244174500en_HK
dc.identifier.scopusauthoridLeung, AWS=36935465800en_HK
dc.identifier.scopusauthoridFox, PT=7402680249en_HK
dc.identifier.scopusauthoridGao, JH=7404475674en_HK
dc.identifier.citeulike5434777-

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