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Article: Unraveling the molecular targets of natural products: Insights from genomic and proteomic analyses

TitleUnraveling the molecular targets of natural products: Insights from genomic and proteomic analyses
Authors
KeywordsChemical proteomics
Expression proteomics
Natural products
Target identification
Transcriptomics
Issue Date2008
PublisherWiley - V C H Verlag GmbH & Co KGaA.
Citation
Proteomics - Clinical Applications, 2008, v. 2 n. 3, p. 338-354 How to Cite?
AbstractNatural products and their derivatives have been an invaluable source of drug leads for the pharmaceutical industry over the past decades, especially for antibacterial and anticancer purposes. Nature products, with their chemical diversity and biochemical specificity, are ideal starting points of drug development. Rational drug design based on natural product scaffolds, however, was hindered by a lack of knowledge regarding their mechanisms of action. Advances in proteomic technologies hold the key to revolutionize the target identification of natural products. In this regard, chemical proteomics have demonstrated the capabilities to identify specific targets by screening against the proteome. On the other hand, high-throughput proteome analysis reveals the multiple impacts of drug-target interaction in a global context, providing insights for elucidation of signaling pathways involved in the drug response, and uncovering predictive markers of drug efficacy and toxicity. Increasingly, studies have exploited integration of transcriptome and proteome datasets, which offers additional information on regulation of molecular network at transcriptional and post-translational levels. In this review, we discuss major proteomic approaches applied to studying the mechanism of action of natural products and merits of combining datasets from proteomics and transcriptomics analysis. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/89330
ISSN
2015 Impact Factor: 2.959
2015 SCImago Journal Rankings: 1.117
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, CCen_HK
dc.contributor.authorCheng, KWen_HK
dc.contributor.authorHe, QYen_HK
dc.contributor.authorChen, Fen_HK
dc.date.accessioned2010-09-06T09:55:29Z-
dc.date.available2010-09-06T09:55:29Z-
dc.date.issued2008en_HK
dc.identifier.citationProteomics - Clinical Applications, 2008, v. 2 n. 3, p. 338-354en_HK
dc.identifier.issn1862-8346en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89330-
dc.description.abstractNatural products and their derivatives have been an invaluable source of drug leads for the pharmaceutical industry over the past decades, especially for antibacterial and anticancer purposes. Nature products, with their chemical diversity and biochemical specificity, are ideal starting points of drug development. Rational drug design based on natural product scaffolds, however, was hindered by a lack of knowledge regarding their mechanisms of action. Advances in proteomic technologies hold the key to revolutionize the target identification of natural products. In this regard, chemical proteomics have demonstrated the capabilities to identify specific targets by screening against the proteome. On the other hand, high-throughput proteome analysis reveals the multiple impacts of drug-target interaction in a global context, providing insights for elucidation of signaling pathways involved in the drug response, and uncovering predictive markers of drug efficacy and toxicity. Increasingly, studies have exploited integration of transcriptome and proteome datasets, which offers additional information on regulation of molecular network at transcriptional and post-translational levels. In this review, we discuss major proteomic approaches applied to studying the mechanism of action of natural products and merits of combining datasets from proteomics and transcriptomics analysis. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA.en_HK
dc.relation.ispartofProteomics - Clinical Applicationsen_HK
dc.subjectChemical proteomicsen_HK
dc.subjectExpression proteomicsen_HK
dc.subjectNatural productsen_HK
dc.subjectTarget identificationen_HK
dc.subjectTranscriptomicsen_HK
dc.titleUnraveling the molecular targets of natural products: Insights from genomic and proteomic analysesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1862-8346&volume=2&spage=338&epage=354&date=2008&atitle=Unraveling+the+molecular+targets+of+natural+products:+Insights+from+genomic+and+proteomic+analysesen_HK
dc.identifier.emailChen, F: sfchen@hku.hken_HK
dc.identifier.authorityChen, F=rp00672en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/prca.200880002en_HK
dc.identifier.scopuseid_2-s2.0-41149173665en_HK
dc.identifier.hkuros147813en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41149173665&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue3en_HK
dc.identifier.spage338en_HK
dc.identifier.epage354en_HK
dc.identifier.isiWOS:000254262900006-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridWong, CC=35333095100en_HK
dc.identifier.scopusauthoridCheng, KW=12141247000en_HK
dc.identifier.scopusauthoridHe, QY=34770287900en_HK
dc.identifier.scopusauthoridChen, F=7404907980en_HK
dc.identifier.citeulike3481405-

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