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Article: Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women

TitleAssociation analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women
Authors
KeywordsAge at menarche
Age at natural menopause
Association
Haplotypes
MTHFR
Polymorphisms
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.com
Citation
Menopause, 2010, v. 17 n. 1, p. 185-190 How to Cite?
AbstractObjective: This study aimed to investigate whether polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene are associated with age at menarche and age at natural menopause in white women. Methods: In a cross-sectional study, a total of 305 randomly selected unrelated white women were genotyped for six single nucleotide polymorphisms (SNPs) of the MTHFR gene (including one common replacement, rs1801133). This sample was comprehensively analyzed for the association of the SNPs with age at menarche. Then a subsample of 210 women who experienced natural menopause was analyzed for the association of the MTHFR gene with age at natural menopause. Results: Duration of breast-feeding was a significant predictor of earlier natural menopause (P < 0.05). No individual SNPs were associated with either age at menarche or age at natural menopause. However, three significant (P < 0.05) SNP-SNP interaction effects (rs2066470/rs1476413, rs2066470/rs4846049, and rs17037390/rs4846049) on the onset of menarche were determined. Three haplotypes were significantly associated with age at menopause (P < 0.05). Four SNPs (rs2066470, rs17037390, rs1801133, and rs4846048) indicated significant interaction effects with various lifestyle factors on age at natural menopause. Conclusions: The results of our study suggest that the MTHFR gene may influence the onset of menarche and natural menopause. This effect is probably due to the multiple SNP-SNP and SNP-environment interactions. More independent studies are needed to further clarify the possible contribution of this gene to the timing of menarche and menopause. © 2010 by The North American Menopause Society.
Persistent Identifierhttp://hdl.handle.net/10722/89312
ISSN
2015 Impact Factor: 3.172
2015 SCImago Journal Rankings: 1.270
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of HealthR01 AR050496
K01 AR02170-01
R01 AR4534901
R01 GM60402-01A1
State of NebraskaLB595
National Science Foundation of China
Huo Ying Dong Education Foundation
HuNan Province
Xi'an Jiaotong University
Ministry of Education of China
Funding Information:

This work, was supported by grants from the National Institutes of Health (R01 AR050496 K01 AR02170-01, R01 AR4534901, and R01 GM60402-01A1) and by the State of Nebraska (grant LB595). The National Science Foundation of China, Huo Ying Dong Education Foundation, HuNan Province, Xi'an Jiaotong University, and the Ministry of Education of China also provided financial support that made this study possible.

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Pen_HK
dc.contributor.authorLu, Yen_HK
dc.contributor.authorRecker, RRen_HK
dc.contributor.authorDeng, HWen_HK
dc.contributor.authorDvornyk, Ven_HK
dc.date.accessioned2010-09-06T09:55:16Z-
dc.date.available2010-09-06T09:55:16Z-
dc.date.issued2010en_HK
dc.identifier.citationMenopause, 2010, v. 17 n. 1, p. 185-190en_HK
dc.identifier.issn1072-3714en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89312-
dc.description.abstractObjective: This study aimed to investigate whether polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene are associated with age at menarche and age at natural menopause in white women. Methods: In a cross-sectional study, a total of 305 randomly selected unrelated white women were genotyped for six single nucleotide polymorphisms (SNPs) of the MTHFR gene (including one common replacement, rs1801133). This sample was comprehensively analyzed for the association of the SNPs with age at menarche. Then a subsample of 210 women who experienced natural menopause was analyzed for the association of the MTHFR gene with age at natural menopause. Results: Duration of breast-feeding was a significant predictor of earlier natural menopause (P < 0.05). No individual SNPs were associated with either age at menarche or age at natural menopause. However, three significant (P < 0.05) SNP-SNP interaction effects (rs2066470/rs1476413, rs2066470/rs4846049, and rs17037390/rs4846049) on the onset of menarche were determined. Three haplotypes were significantly associated with age at menopause (P < 0.05). Four SNPs (rs2066470, rs17037390, rs1801133, and rs4846048) indicated significant interaction effects with various lifestyle factors on age at natural menopause. Conclusions: The results of our study suggest that the MTHFR gene may influence the onset of menarche and natural menopause. This effect is probably due to the multiple SNP-SNP and SNP-environment interactions. More independent studies are needed to further clarify the possible contribution of this gene to the timing of menarche and menopause. © 2010 by The North American Menopause Society.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.comen_HK
dc.relation.ispartofMenopauseen_HK
dc.rightsMenopause. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectAge at menarcheen_HK
dc.subjectAge at natural menopauseen_HK
dc.subjectAssociationen_HK
dc.subjectHaplotypesen_HK
dc.subjectMTHFRen_HK
dc.subjectPolymorphismsen_HK
dc.titleAssociation analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1072-3714&volume=17&spage=185&epage=190&date=2010&atitle=Association+analyses+suggest+multiple+interaction+effects+of+the+methylenetetrahydrofolate+reductase+polymorphisms+on+timing+of+menarche+and+natural+menopause+in+whitesen_HK
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_HK
dc.identifier.authorityDvornyk, V=rp00693en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1097/gme.0b013e3181aa2597en_HK
dc.identifier.pmid19593234-
dc.identifier.pmcidPMC2806497-
dc.identifier.scopuseid_2-s2.0-74549152666en_HK
dc.identifier.hkuros168555en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-74549152666&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue1en_HK
dc.identifier.spage185en_HK
dc.identifier.epage190en_HK
dc.identifier.isiWOS:000273517400031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, P=7404618030en_HK
dc.identifier.scopusauthoridLu, Y=26643076900en_HK
dc.identifier.scopusauthoridRecker, RR=7007086875en_HK
dc.identifier.scopusauthoridDeng, HW=7401775190en_HK
dc.identifier.scopusauthoridDvornyk, V=6701789786en_HK

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