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Article: Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea

TitleUrinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea
Authors
KeywordsAflatoxins
Children
Egypt
Guinea
Urine
Weaning
Issue Date2008
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/foodchemtox
Citation
Food And Chemical Toxicology, 2008, v. 46 n. 2, p. 519-526 How to Cite?
AbstractAflatoxins are a major risk factor for hepatocellular carcinoma (HCC), and thus understanding the pattern of aflatoxin exposure in different regions is important in order to develop targeted intervention strategies. Given the early onset of HCC in many countries early life exposures may be important. This study investigated aflatoxin exposure in Egyptian children (n = 50, aged 1-2.5 years) by assessing urinary aflatoxin metabolite (AFM 1, AFB 1, AFB 2, AFG 1, AFG 2) levels. Samples from Guinean children (n = 50, aged 2-4 years) were analyzed in parallel providing a comparison to a region of established frequent aflatoxin exposure. Aflatoxins were isolated from urine using C18-cartridges followed by immunoaffinity clean-up, and quantified by HPLC with fluorescence detection. Overall aflatoxins were less frequently present in Egyptian (38%) than Guinean urine samples (86%) (p < 0.001), which was particularly related to differences in detection rates of AFM 1 (8% compared to 64%, respectively, (p < 0.001)). For AFM 1 the geometric mean level in Guinea (16.3 pg/ml; 95% CI: 10.1, 26.6 pg/ml) was 6-fold higher (p < 0.001) than in Egypt (2.7 pg/ml; 95% CI: 2.5, 2.8 pg/ml). Urinary aflatoxins from healthy children in these two regions have not previously been reported, and exposure appears modest in Egypt compared to Guinea. These data suggest that measures to reduce aflatoxin exposure in both regions are important, though particularly in Guinea. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89301
ISSN
2015 Impact Factor: 3.584
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPolychronaki, Nen_HK
dc.contributor.authorWild, CPen_HK
dc.contributor.authorMykkänen, Hen_HK
dc.contributor.authorAmra, Hen_HK
dc.contributor.authorAbdelWahhab, Men_HK
dc.contributor.authorSylla, Aen_HK
dc.contributor.authorDiallo, Men_HK
dc.contributor.authorElNezami, Hen_HK
dc.contributor.authorTurner, PCen_HK
dc.date.accessioned2010-09-06T09:55:07Z-
dc.date.available2010-09-06T09:55:07Z-
dc.date.issued2008en_HK
dc.identifier.citationFood And Chemical Toxicology, 2008, v. 46 n. 2, p. 519-526en_HK
dc.identifier.issn0278-6915en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89301-
dc.description.abstractAflatoxins are a major risk factor for hepatocellular carcinoma (HCC), and thus understanding the pattern of aflatoxin exposure in different regions is important in order to develop targeted intervention strategies. Given the early onset of HCC in many countries early life exposures may be important. This study investigated aflatoxin exposure in Egyptian children (n = 50, aged 1-2.5 years) by assessing urinary aflatoxin metabolite (AFM 1, AFB 1, AFB 2, AFG 1, AFG 2) levels. Samples from Guinean children (n = 50, aged 2-4 years) were analyzed in parallel providing a comparison to a region of established frequent aflatoxin exposure. Aflatoxins were isolated from urine using C18-cartridges followed by immunoaffinity clean-up, and quantified by HPLC with fluorescence detection. Overall aflatoxins were less frequently present in Egyptian (38%) than Guinean urine samples (86%) (p < 0.001), which was particularly related to differences in detection rates of AFM 1 (8% compared to 64%, respectively, (p < 0.001)). For AFM 1 the geometric mean level in Guinea (16.3 pg/ml; 95% CI: 10.1, 26.6 pg/ml) was 6-fold higher (p < 0.001) than in Egypt (2.7 pg/ml; 95% CI: 2.5, 2.8 pg/ml). Urinary aflatoxins from healthy children in these two regions have not previously been reported, and exposure appears modest in Egypt compared to Guinea. These data suggest that measures to reduce aflatoxin exposure in both regions are important, though particularly in Guinea. © 2007 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/foodchemtoxen_HK
dc.relation.ispartofFood and Chemical Toxicologyen_HK
dc.subjectAflatoxinsen_HK
dc.subjectChildrenen_HK
dc.subjectEgypten_HK
dc.subjectGuineaen_HK
dc.subjectUrineen_HK
dc.subjectWeaningen_HK
dc.titleUrinary biomarkers of aflatoxin exposure in young children from Egypt and Guineaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-6915&volume=46&spage=519&epage=26&date=2008&atitle=Urinary+biomarkers+of+aflatoxin+exposure+in+young+children+from+Egypt+and+Guinea.en_HK
dc.identifier.emailElNezami, H: elnezami@hkucc.hku.hken_HK
dc.identifier.authorityElNezami, H=rp00694en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.fct.2007.08.034en_HK
dc.identifier.pmid17920747-
dc.identifier.scopuseid_2-s2.0-37449022597en_HK
dc.identifier.hkuros151556en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37449022597&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue2en_HK
dc.identifier.spage519en_HK
dc.identifier.epage526en_HK
dc.identifier.isiWOS:000253577400012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPolychronaki, N=6505944468en_HK
dc.identifier.scopusauthoridWild, CP=7103360152en_HK
dc.identifier.scopusauthoridMykkänen, H=7003915985en_HK
dc.identifier.scopusauthoridAmra, H=14014308000en_HK
dc.identifier.scopusauthoridAbdelWahhab, M=8087610600en_HK
dc.identifier.scopusauthoridSylla, A=7004932294en_HK
dc.identifier.scopusauthoridDiallo, M=55401215000en_HK
dc.identifier.scopusauthoridElNezami, H=6603690577en_HK
dc.identifier.scopusauthoridTurner, PC=7402096074en_HK

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