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Article: Immunolocalization assessment of metastasis-associated protein 1 in human and mouse mature testes and its association with spermatogenesis

TitleImmunolocalization assessment of metastasis-associated protein 1 in human and mouse mature testes and its association with spermatogenesis
Authors
KeywordsChromatin remodeling
Deacetylation
Human metastasis-associated protein 1
Mouse metastasis-associated protein 1
Nuclear remodeling and deacetylation complex
Spermatogenesis
Spermiogenesis
Issue Date2007
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1008-682X&site=1
Citation
Asian Journal Of Andrology, 2007, v. 9 n. 3, p. 345-352 How to Cite?
AbstractAim: To investigate the stage-specific localization of metastasis-associated protein 1 (MTA1) during spermatogenesis in adult human and mouse testis. Methods: The immunolocalization of MTA1 was studied by immunohistochemistry and Western blot analysis. The distribution pattern of MTA1 in mouse testis was confirmed by using quantitative analysis of purified spermatogenic cells. Results: The specificity of polyclonal antibody was confirmed by Western blot analysis. MTA1 was found expressed in the nucleus of germ cells, except elongate spermatids, and in the cytoplasm of Sertoli cells; Leydig cells did not show any specific reactivity. MTA1 possessed different distribution patterns in the two species: in humans, the most intensive staining was found in the nucleus of round spermatids and of primary spermatocytes while in mice, the most intense MTA1 staining was in the nucleus of leptotene, zygotene and pachytene spermatocytes. In both species the staining exhibited a cyclic pattern. Conclusion: The present communication initially provides new evidence for the potential role of MTA1 in mature testis. In addition, its distinctive expression in germ cells suggests a regulatory role of the peptide during spermatogenesis. © 2007 Asian Journal of Andrology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Persistent Identifierhttp://hdl.handle.net/10722/89300
ISSN
2015 Impact Factor: 2.644
2015 SCImago Journal Rankings: 0.879
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Wen_HK
dc.contributor.authorLiu, XPen_HK
dc.contributor.authorXu, RJen_HK
dc.contributor.authorZhang, YQen_HK
dc.date.accessioned2010-09-06T09:55:07Z-
dc.date.available2010-09-06T09:55:07Z-
dc.date.issued2007en_HK
dc.identifier.citationAsian Journal Of Andrology, 2007, v. 9 n. 3, p. 345-352en_HK
dc.identifier.issn1008-682Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/89300-
dc.description.abstractAim: To investigate the stage-specific localization of metastasis-associated protein 1 (MTA1) during spermatogenesis in adult human and mouse testis. Methods: The immunolocalization of MTA1 was studied by immunohistochemistry and Western blot analysis. The distribution pattern of MTA1 in mouse testis was confirmed by using quantitative analysis of purified spermatogenic cells. Results: The specificity of polyclonal antibody was confirmed by Western blot analysis. MTA1 was found expressed in the nucleus of germ cells, except elongate spermatids, and in the cytoplasm of Sertoli cells; Leydig cells did not show any specific reactivity. MTA1 possessed different distribution patterns in the two species: in humans, the most intensive staining was found in the nucleus of round spermatids and of primary spermatocytes while in mice, the most intense MTA1 staining was in the nucleus of leptotene, zygotene and pachytene spermatocytes. In both species the staining exhibited a cyclic pattern. Conclusion: The present communication initially provides new evidence for the potential role of MTA1 in mature testis. In addition, its distinctive expression in germ cells suggests a regulatory role of the peptide during spermatogenesis. © 2007 Asian Journal of Andrology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=1008-682X&site=1en_HK
dc.relation.ispartofAsian Journal of Andrologyen_HK
dc.subjectChromatin remodelingen_HK
dc.subjectDeacetylationen_HK
dc.subjectHuman metastasis-associated protein 1en_HK
dc.subjectMouse metastasis-associated protein 1en_HK
dc.subjectNuclear remodeling and deacetylation complexen_HK
dc.subjectSpermatogenesisen_HK
dc.subjectSpermiogenesisen_HK
dc.titleImmunolocalization assessment of metastasis-associated protein 1 in human and mouse mature testes and its association with spermatogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1008-682X&volume=9&spage=345&epage=352&date=2007&atitle=Immunolocalization+assessment+of+metastasis-associated+protein+1+in+human+and+mouse+mature+testes+and+its+association+with+spermatogenesisen_HK
dc.identifier.emailXu, RJ: xuruojun@hkucc.hku.hken_HK
dc.identifier.authorityXu, RJ=rp00820en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1745-7262.2007.00245.xen_HK
dc.identifier.pmid17486275-
dc.identifier.scopuseid_2-s2.0-34347232381en_HK
dc.identifier.hkuros151112en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34347232381&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue3en_HK
dc.identifier.spage345en_HK
dc.identifier.epage352en_HK
dc.identifier.isiWOS:000246396900008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, W=36065387400en_HK
dc.identifier.scopusauthoridLiu, XP=36062592700en_HK
dc.identifier.scopusauthoridXu, RJ=7402813973en_HK
dc.identifier.scopusauthoridZhang, YQ=7601321843en_HK
dc.identifier.citeulike1297627-

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