Article: Endophytic fungi from Nerium oleander L (Apocynaceae): Main constituents and antioxidant activity

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Title	Endophytic fungi from Nerium oleander L (Apocynaceae): Main constituents and antioxidant activity
Authors	Huang, WY1 Cai, YZ1 Hyde, KD1 Corke, H1 Sun, M1
Keywords	Antimicrobial activity Antioxidant activity Apocynaceae Endophytic fungi Nerium oleander Total phenolic content Xanthine oxidase inhibition
Issue Date	2007
Publisher	Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0959-3993
Citation	World Journal Of Microbiology And Biotechnology, 2007, v. 23 n. 9, p. 1253-1263 [How to Cite?] DOI: http://dx.doi.org/10.1007/s11274-007-9357-z
Abstract	Diverse endophytic fungi exist within plant aerial tissues, with a global estimate of up to a million undescribed species. These endophytes constitute a rich bio-resource for exploration to discover new natural products. Here we investigate fungal endophytes associated with a medicinal plant, Nerium oleander L. (Apocynaceae). A total of 42 endophytic fungal strains were isolated from the host plant. Total antioxidant capacity, xanthine oxidase inhibitory activity, antimicrobial activity, and total phenolic content (TPC) were evaluated for 16 representative fungal cultures grown in improved Czapek's broth and for the host plant. The total antioxidant capacities and phenolic contents of the fungal cultures ranged from 9.59 to 150.79 μmol trolox/100 mL culture, and from 0.52 to 13.95 mg gallic acid/100 mL culture, respectively. The fungal culture of an endophytic strain Chaetomium sp. showed the strongest antioxidant capacity, contained the highest level of phenolics, and to some extent inhibited xanthine oxidase activity with an IC50 value of 109.8 μg/mL. A significant positive correlation was found between antioxidant capacity and TPC in the tested samples. Most of the endophytic fungal cultures tested have a wide range of antimicrobial activities, which were not very strong, but much better than those of the host plant. The major bioactive constituents of the fungal cultures were investigated using LC-ESI-MS and GC-MS, and preliminary identification detected phenolics (e.g. phenolic acids and their derivatives, flavonoids) and volatile and aliphatic compounds. This study shows that the endophytic fungi isolated from N. oleander can be a potential antioxidant resource. © 2007 Springer Science+Business Media B.V.
ISSN	0959-3993 2011 Impact Factor: 1.532 2011 SCImago Journal Rankings: 0.070
DOI	http://dx.doi.org/10.1007/s11274-007-9357-z
ISI Accession Number ID	WOS:000249057700009
References	References in Scopus

DC Field	Value
dc.contributor.author	Huang, WY
dc.contributor.author	Cai, YZ
dc.contributor.author	Hyde, KD
dc.contributor.author	Corke, H
dc.contributor.author	Sun, M
dc.date.accessioned	2010-09-06T09:55:04Z
dc.date.available	2010-09-06T09:55:04Z
dc.date.issued	2007
dc.description.abstract	Diverse endophytic fungi exist within plant aerial tissues, with a global estimate of up to a million undescribed species. These endophytes constitute a rich bio-resource for exploration to discover new natural products. Here we investigate fungal endophytes associated with a medicinal plant, Nerium oleander L. (Apocynaceae). A total of 42 endophytic fungal strains were isolated from the host plant. Total antioxidant capacity, xanthine oxidase inhibitory activity, antimicrobial activity, and total phenolic content (TPC) were evaluated for 16 representative fungal cultures grown in improved Czapek's broth and for the host plant. The total antioxidant capacities and phenolic contents of the fungal cultures ranged from 9.59 to 150.79 μmol trolox/100 mL culture, and from 0.52 to 13.95 mg gallic acid/100 mL culture, respectively. The fungal culture of an endophytic strain Chaetomium sp. showed the strongest antioxidant capacity, contained the highest level of phenolics, and to some extent inhibited xanthine oxidase activity with an IC50 value of 109.8 μg/mL. A significant positive correlation was found between antioxidant capacity and TPC in the tested samples. Most of the endophytic fungal cultures tested have a wide range of antimicrobial activities, which were not very strong, but much better than those of the host plant. The major bioactive constituents of the fungal cultures were investigated using LC-ESI-MS and GC-MS, and preliminary identification detected phenolics (e.g. phenolic acids and their derivatives, flavonoids) and volatile and aliphatic compounds. This study shows that the endophytic fungi isolated from N. oleander can be a potential antioxidant resource. © 2007 Springer Science+Business Media B.V.
dc.description.nature	postprint
dc.identifier.citation	World Journal Of Microbiology And Biotechnology, 2007, v. 23 n. 9, p. 1253-1263 [How to Cite?] DOI: http://dx.doi.org/10.1007/s11274-007-9357-z
dc.identifier.doi	http://dx.doi.org/10.1007/s11274-007-9357-z
dc.identifier.epage	1263
dc.identifier.hkuros	142659
dc.identifier.isi	WOS:000249057700009
dc.identifier.issn	0959-3993 2011 Impact Factor: 1.532 2011 SCImago Journal Rankings: 0.070
dc.identifier.issue	9
dc.identifier.openurl
dc.identifier.scopus	eid_2-s2.0-34547828035
dc.identifier.spage	1253
dc.identifier.uri	http://hdl.handle.net/10722/89296
dc.identifier.volume	23
dc.language	eng
dc.publisher	Springer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0959-3993
dc.publisher.place	Netherlands
dc.relation.ispartof	World Journal of Microbiology and Biotechnology
dc.relation.references	References in Scopus
dc.rights	The original publication is available at www.springerlink.com
dc.rights	Creative Commons: Attribution 3.0 Hong Kong License
dc.subject	Antimicrobial activity
dc.subject	Antioxidant activity
dc.subject	Apocynaceae
dc.subject	Endophytic fungi
dc.subject	Nerium oleander
dc.subject	Total phenolic content
dc.subject	Xanthine oxidase inhibition
dc.title	Endophytic fungi from Nerium oleander L (Apocynaceae): Main constituents and antioxidant activity
dc.type	Article

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Author Affiliations

The University of Hong Kong