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Article: Endophytic fungi from Nerium oleander L (Apocynaceae): Main constituents and antioxidant activity

TitleEndophytic fungi from Nerium oleander L (Apocynaceae): Main constituents and antioxidant activity
Authors
KeywordsAntimicrobial activity
Antioxidant activity
Apocynaceae
Endophytic fungi
Nerium oleander
Total phenolic content
Xanthine oxidase inhibition
Issue Date2007
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0959-3993
Citation
World Journal Of Microbiology And Biotechnology, 2007, v. 23 n. 9, p. 1253-1263 How to Cite?
AbstractDiverse endophytic fungi exist within plant aerial tissues, with a global estimate of up to a million undescribed species. These endophytes constitute a rich bio-resource for exploration to discover new natural products. Here we investigate fungal endophytes associated with a medicinal plant, Nerium oleander L. (Apocynaceae). A total of 42 endophytic fungal strains were isolated from the host plant. Total antioxidant capacity, xanthine oxidase inhibitory activity, antimicrobial activity, and total phenolic content (TPC) were evaluated for 16 representative fungal cultures grown in improved Czapek's broth and for the host plant. The total antioxidant capacities and phenolic contents of the fungal cultures ranged from 9.59 to 150.79 μmol trolox/100 mL culture, and from 0.52 to 13.95 mg gallic acid/100 mL culture, respectively. The fungal culture of an endophytic strain Chaetomium sp. showed the strongest antioxidant capacity, contained the highest level of phenolics, and to some extent inhibited xanthine oxidase activity with an IC50 value of 109.8 μg/mL. A significant positive correlation was found between antioxidant capacity and TPC in the tested samples. Most of the endophytic fungal cultures tested have a wide range of antimicrobial activities, which were not very strong, but much better than those of the host plant. The major bioactive constituents of the fungal cultures were investigated using LC-ESI-MS and GC-MS, and preliminary identification detected phenolics (e.g. phenolic acids and their derivatives, flavonoids) and volatile and aliphatic compounds. This study shows that the endophytic fungi isolated from N. oleander can be a potential antioxidant resource. © 2007 Springer Science+Business Media B.V.
Persistent Identifierhttp://hdl.handle.net/10722/89296
ISSN
2015 Impact Factor: 1.532
2015 SCImago Journal Rankings: 0.634
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, WYen_HK
dc.contributor.authorCai, YZen_HK
dc.contributor.authorHyde, KDen_HK
dc.contributor.authorCorke, Hen_HK
dc.contributor.authorSun, Men_HK
dc.date.accessioned2010-09-06T09:55:04Z-
dc.date.available2010-09-06T09:55:04Z-
dc.date.issued2007en_HK
dc.identifier.citationWorld Journal Of Microbiology And Biotechnology, 2007, v. 23 n. 9, p. 1253-1263en_HK
dc.identifier.issn0959-3993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89296-
dc.description.abstractDiverse endophytic fungi exist within plant aerial tissues, with a global estimate of up to a million undescribed species. These endophytes constitute a rich bio-resource for exploration to discover new natural products. Here we investigate fungal endophytes associated with a medicinal plant, Nerium oleander L. (Apocynaceae). A total of 42 endophytic fungal strains were isolated from the host plant. Total antioxidant capacity, xanthine oxidase inhibitory activity, antimicrobial activity, and total phenolic content (TPC) were evaluated for 16 representative fungal cultures grown in improved Czapek's broth and for the host plant. The total antioxidant capacities and phenolic contents of the fungal cultures ranged from 9.59 to 150.79 μmol trolox/100 mL culture, and from 0.52 to 13.95 mg gallic acid/100 mL culture, respectively. The fungal culture of an endophytic strain Chaetomium sp. showed the strongest antioxidant capacity, contained the highest level of phenolics, and to some extent inhibited xanthine oxidase activity with an IC50 value of 109.8 μg/mL. A significant positive correlation was found between antioxidant capacity and TPC in the tested samples. Most of the endophytic fungal cultures tested have a wide range of antimicrobial activities, which were not very strong, but much better than those of the host plant. The major bioactive constituents of the fungal cultures were investigated using LC-ESI-MS and GC-MS, and preliminary identification detected phenolics (e.g. phenolic acids and their derivatives, flavonoids) and volatile and aliphatic compounds. This study shows that the endophytic fungi isolated from N. oleander can be a potential antioxidant resource. © 2007 Springer Science+Business Media B.V.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0959-3993en_HK
dc.relation.ispartofWorld Journal of Microbiology and Biotechnologyen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAntimicrobial activityen_HK
dc.subjectAntioxidant activityen_HK
dc.subjectApocynaceaeen_HK
dc.subjectEndophytic fungien_HK
dc.subjectNerium oleanderen_HK
dc.subjectTotal phenolic contenten_HK
dc.subjectXanthine oxidase inhibitionen_HK
dc.titleEndophytic fungi from Nerium oleander L (Apocynaceae): Main constituents and antioxidant activityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-3993&volume=23&issue=9&spage=1253&epage=1263&date=2007&atitle=Endophytic+fungi+from+Nerium+oleander+L+(Apocynaceae):+main+constituents+and+antioxidant+activityen_HK
dc.identifier.emailCai, YZ: yzcai@hkucc.hku.hken_HK
dc.identifier.emailCorke, H: harold@hku.hken_HK
dc.identifier.emailSun, M: meisun@hkucc.hku.hken_HK
dc.identifier.authorityCai, YZ=rp00661en_HK
dc.identifier.authorityCorke, H=rp00688en_HK
dc.identifier.authoritySun, M=rp00779en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1007/s11274-007-9357-zen_HK
dc.identifier.scopuseid_2-s2.0-34547828035en_HK
dc.identifier.hkuros142659en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547828035&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1253en_HK
dc.identifier.epage1263en_HK
dc.identifier.isiWOS:000249057700009-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHuang, WY=16233667500en_HK
dc.identifier.scopusauthoridCai, YZ=8684149300en_HK
dc.identifier.scopusauthoridHyde, KD=7102588111en_HK
dc.identifier.scopusauthoridCorke, H=7007102942en_HK
dc.identifier.scopusauthoridSun, M=7403181447en_HK

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