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Article: Endophytic fungi from Nerium oleander L (Apocynaceae): Main constituents and antioxidant activity
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TitleEndophytic fungi from Nerium oleander L (Apocynaceae): Main constituents and antioxidant activity
 
AuthorsHuang, WY1
Cai, YZ1
Hyde, KD1
Corke, H1
Sun, M1
 
KeywordsAntimicrobial activity
Antioxidant activity
Apocynaceae
Endophytic fungi
Nerium oleander
Total phenolic content
Xanthine oxidase inhibition
 
Issue Date2007
 
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0959-3993
 
CitationWorld Journal Of Microbiology And Biotechnology, 2007, v. 23 n. 9, p. 1253-1263 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11274-007-9357-z
 
AbstractDiverse endophytic fungi exist within plant aerial tissues, with a global estimate of up to a million undescribed species. These endophytes constitute a rich bio-resource for exploration to discover new natural products. Here we investigate fungal endophytes associated with a medicinal plant, Nerium oleander L. (Apocynaceae). A total of 42 endophytic fungal strains were isolated from the host plant. Total antioxidant capacity, xanthine oxidase inhibitory activity, antimicrobial activity, and total phenolic content (TPC) were evaluated for 16 representative fungal cultures grown in improved Czapek's broth and for the host plant. The total antioxidant capacities and phenolic contents of the fungal cultures ranged from 9.59 to 150.79 μmol trolox/100 mL culture, and from 0.52 to 13.95 mg gallic acid/100 mL culture, respectively. The fungal culture of an endophytic strain Chaetomium sp. showed the strongest antioxidant capacity, contained the highest level of phenolics, and to some extent inhibited xanthine oxidase activity with an IC50 value of 109.8 μg/mL. A significant positive correlation was found between antioxidant capacity and TPC in the tested samples. Most of the endophytic fungal cultures tested have a wide range of antimicrobial activities, which were not very strong, but much better than those of the host plant. The major bioactive constituents of the fungal cultures were investigated using LC-ESI-MS and GC-MS, and preliminary identification detected phenolics (e.g. phenolic acids and their derivatives, flavonoids) and volatile and aliphatic compounds. This study shows that the endophytic fungi isolated from N. oleander can be a potential antioxidant resource. © 2007 Springer Science+Business Media B.V.
 
ISSN0959-3993
2013 Impact Factor: 1.353
 
DOIhttp://dx.doi.org/10.1007/s11274-007-9357-z
 
ISI Accession Number IDWOS:000249057700009
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHuang, WY
 
dc.contributor.authorCai, YZ
 
dc.contributor.authorHyde, KD
 
dc.contributor.authorCorke, H
 
dc.contributor.authorSun, M
 
dc.date.accessioned2010-09-06T09:55:04Z
 
dc.date.available2010-09-06T09:55:04Z
 
dc.date.issued2007
 
dc.description.abstractDiverse endophytic fungi exist within plant aerial tissues, with a global estimate of up to a million undescribed species. These endophytes constitute a rich bio-resource for exploration to discover new natural products. Here we investigate fungal endophytes associated with a medicinal plant, Nerium oleander L. (Apocynaceae). A total of 42 endophytic fungal strains were isolated from the host plant. Total antioxidant capacity, xanthine oxidase inhibitory activity, antimicrobial activity, and total phenolic content (TPC) were evaluated for 16 representative fungal cultures grown in improved Czapek's broth and for the host plant. The total antioxidant capacities and phenolic contents of the fungal cultures ranged from 9.59 to 150.79 μmol trolox/100 mL culture, and from 0.52 to 13.95 mg gallic acid/100 mL culture, respectively. The fungal culture of an endophytic strain Chaetomium sp. showed the strongest antioxidant capacity, contained the highest level of phenolics, and to some extent inhibited xanthine oxidase activity with an IC50 value of 109.8 μg/mL. A significant positive correlation was found between antioxidant capacity and TPC in the tested samples. Most of the endophytic fungal cultures tested have a wide range of antimicrobial activities, which were not very strong, but much better than those of the host plant. The major bioactive constituents of the fungal cultures were investigated using LC-ESI-MS and GC-MS, and preliminary identification detected phenolics (e.g. phenolic acids and their derivatives, flavonoids) and volatile and aliphatic compounds. This study shows that the endophytic fungi isolated from N. oleander can be a potential antioxidant resource. © 2007 Springer Science+Business Media B.V.
 
dc.description.naturepostprint
 
dc.identifier.citationWorld Journal Of Microbiology And Biotechnology, 2007, v. 23 n. 9, p. 1253-1263 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11274-007-9357-z
 
dc.identifier.doihttp://dx.doi.org/10.1007/s11274-007-9357-z
 
dc.identifier.epage1263
 
dc.identifier.hkuros142659
 
dc.identifier.isiWOS:000249057700009
 
dc.identifier.issn0959-3993
2013 Impact Factor: 1.353
 
dc.identifier.issue9
 
dc.identifier.openurl
 
dc.identifier.scopuseid_2-s2.0-34547828035
 
dc.identifier.spage1253
 
dc.identifier.urihttp://hdl.handle.net/10722/89296
 
dc.identifier.volume23
 
dc.languageeng
 
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0959-3993
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofWorld Journal of Microbiology and Biotechnology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe original publication is available at www.springerlink.com
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectAntimicrobial activity
 
dc.subjectAntioxidant activity
 
dc.subjectApocynaceae
 
dc.subjectEndophytic fungi
 
dc.subjectNerium oleander
 
dc.subjectTotal phenolic content
 
dc.subjectXanthine oxidase inhibition
 
dc.titleEndophytic fungi from Nerium oleander L (Apocynaceae): Main constituents and antioxidant activity
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong