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Article: Molecular mechanisms by which hormones and cytokines regulate cell junction dynamics in the testis

TitleMolecular mechanisms by which hormones and cytokines regulate cell junction dynamics in the testis
Authors
Issue Date2009
PublisherSociety for Endocrinology. The Journal's web site is located at http://jme.endocrinology-journals.org/
Citation
Journal Of Molecular Endocrinology, 2009, v. 43 n. 2, p. 43-51 How to Cite?
AbstractHormones and cytokines are known to regulate cellular functions in all tissues including testis. These two groups of biomolecules exert a broad spectrum of effects on various aspects of spermatogenesis. Among them, one of the regulatory effects on spermatogenesis is to modulate cell junction restructuring between Sertoli cells and between Sertoli and germ cells in the seminiferous epithelium. The restructuring of cell junctions is crucial to enable the migration of germ cells along the seminiferous epithelium from the basement membrane towards the tubular lumen, and at the same time for their attachment to Sertoli cells for support. This review will summarize the recent findings that focus on the role of hormones (FSH and testosterone) and cytokines (transforming growth factor-βs and tumor necrosis factor-α) on cell junction restructuring in the testis and the molecular mechanisms. © 2009 Society for Endocrinology.
Persistent Identifierhttp://hdl.handle.net/10722/89293
ISSN
2015 Impact Factor: 2.947
2015 SCImago Journal Rankings: 1.674
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU7715/07M
HKU7693/07M
Funding Information:

This work was supported by Hong Kong Research Grants Council (HKU7715/07M to W-Y and HKU7693/07M to W M L).

References

 

DC FieldValueLanguage
dc.contributor.authorLui, WYen_HK
dc.contributor.authorLee, WMen_HK
dc.date.accessioned2010-09-06T09:55:01Z-
dc.date.available2010-09-06T09:55:01Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Molecular Endocrinology, 2009, v. 43 n. 2, p. 43-51en_HK
dc.identifier.issn0952-5041en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89293-
dc.description.abstractHormones and cytokines are known to regulate cellular functions in all tissues including testis. These two groups of biomolecules exert a broad spectrum of effects on various aspects of spermatogenesis. Among them, one of the regulatory effects on spermatogenesis is to modulate cell junction restructuring between Sertoli cells and between Sertoli and germ cells in the seminiferous epithelium. The restructuring of cell junctions is crucial to enable the migration of germ cells along the seminiferous epithelium from the basement membrane towards the tubular lumen, and at the same time for their attachment to Sertoli cells for support. This review will summarize the recent findings that focus on the role of hormones (FSH and testosterone) and cytokines (transforming growth factor-βs and tumor necrosis factor-α) on cell junction restructuring in the testis and the molecular mechanisms. © 2009 Society for Endocrinology.en_HK
dc.languageengen_HK
dc.publisherSociety for Endocrinology. The Journal's web site is located at http://jme.endocrinology-journals.org/en_HK
dc.relation.ispartofJournal of Molecular Endocrinologyen_HK
dc.rightsJournal of Molecular Endocrinology. Copyright © Society for Endocrinology.en_HK
dc.titleMolecular mechanisms by which hormones and cytokines regulate cell junction dynamics in the testisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0952-5041&volume=43&spage=43&epage=51&date=2009&atitle=Molecular+mechanisms+by+which+hormones+and+cytokines+regulate+cell+junction+dynamics+in+the+testisen_HK
dc.identifier.emailLui, WY: wylui@hku.hken_HK
dc.identifier.emailLee, WM: hrszlwm@hku.hken_HK
dc.identifier.authorityLui, WY=rp00756en_HK
dc.identifier.authorityLee, WM=rp00728en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1677/JME-08-0174en_HK
dc.identifier.pmid19273571-
dc.identifier.scopuseid_2-s2.0-69849087884en_HK
dc.identifier.hkuros159921en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69849087884&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue2en_HK
dc.identifier.spage43en_HK
dc.identifier.epage51en_HK
dc.identifier.isiWOS:000272630600005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLui, WY=35220192400en_HK
dc.identifier.scopusauthoridLee, WM=24799156600en_HK
dc.identifier.citeulike6611753-

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