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Article: Proteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: Analysis of significant proteins that manipulate T cells proliferation and immunosuppression

TitleProteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: Analysis of significant proteins that manipulate T cells proliferation and immunosuppression
Authors
KeywordsCoriolus versicolor
Cyclosporine A
Human T lymphocytes
Polysaccharopeptide
Proteomics
Two dimensional gel electrophoresis
Issue Date2007
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/intimp
Citation
International Immunopharmacology, 2007, v. 7 n. 10, p. 1311-1324 How to Cite?
AbstractThe aberrant activation of T lymphocyte proliferation is one of the key events in organ transplant recipients and autoimmune disorders. The present study adopted a gel-based proteomics approach to define the proteins representative of the T cell proliferation and to discover the molecules that play critical roles during the suppression of T cell proliferation. Human T lymphocytes were isolated from healthy donors and primed with phytohemagglutinin (PHA) to undergo proliferation. Two medical fungal products with specific T cell activation inhibitory properties, cyclosporine A (CsA) and polysaccharopeptide (PSP), were used to study the proteins that manipulate T cell proliferation. After demonstrating their similar effects on cell proliferation, cell survival and interleuklin-2 (IL-2) secretion, significant quantitative protein alterations were detected between the CsA- and PSP-treated T cell proteome. These altered proteins were identified by MALDI-TOF and classified into 3 categories: (i) proteins affected by both CsA and PSP, (ii) proteins affected by CsA alone, and (iii) proteins affected by PSP alone. Most of these altered proteins have functional significance in protein degradation, the antioxidant pathway, energy metabolism and immune cell regulation. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89262
ISSN
2015 Impact Factor: 2.551
2015 SCImago Journal Rankings: 0.941
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, CLen_HK
dc.contributor.authorJiang, PPen_HK
dc.contributor.authorSit, WHen_HK
dc.contributor.authorWan, JMFen_HK
dc.date.accessioned2010-09-06T09:54:37Z-
dc.date.available2010-09-06T09:54:37Z-
dc.date.issued2007en_HK
dc.identifier.citationInternational Immunopharmacology, 2007, v. 7 n. 10, p. 1311-1324en_HK
dc.identifier.issn1567-5769en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89262-
dc.description.abstractThe aberrant activation of T lymphocyte proliferation is one of the key events in organ transplant recipients and autoimmune disorders. The present study adopted a gel-based proteomics approach to define the proteins representative of the T cell proliferation and to discover the molecules that play critical roles during the suppression of T cell proliferation. Human T lymphocytes were isolated from healthy donors and primed with phytohemagglutinin (PHA) to undergo proliferation. Two medical fungal products with specific T cell activation inhibitory properties, cyclosporine A (CsA) and polysaccharopeptide (PSP), were used to study the proteins that manipulate T cell proliferation. After demonstrating their similar effects on cell proliferation, cell survival and interleuklin-2 (IL-2) secretion, significant quantitative protein alterations were detected between the CsA- and PSP-treated T cell proteome. These altered proteins were identified by MALDI-TOF and classified into 3 categories: (i) proteins affected by both CsA and PSP, (ii) proteins affected by CsA alone, and (iii) proteins affected by PSP alone. Most of these altered proteins have functional significance in protein degradation, the antioxidant pathway, energy metabolism and immune cell regulation. © 2007 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/intimpen_HK
dc.relation.ispartofInternational Immunopharmacologyen_HK
dc.rightsInternational Immunopharmacology. Copyright © Elsevier Ltd.en_HK
dc.subjectCoriolus versicoloren_HK
dc.subjectCyclosporine Aen_HK
dc.subjectHuman T lymphocytesen_HK
dc.subjectPolysaccharopeptideen_HK
dc.subjectProteomicsen_HK
dc.subjectTwo dimensional gel electrophoresisen_HK
dc.titleProteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: Analysis of significant proteins that manipulate T cells proliferation and immunosuppressionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1567-5769&volume=7&spage=1311&epage=1324&date=2007&atitle=Proteome+of+human+T+lymphocytes+with+treatment+of+cyclosporine+and+polysaccharopeptide:+Analysis+of+significant+proteins+that+manipulate+T+cells+proliferation+and+immunosuppressionen_HK
dc.identifier.emailWan, JMF: jmfwan@hku.hken_HK
dc.identifier.authorityWan, JMF=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.intimp.2007.05.013en_HK
dc.identifier.pmid17673146-
dc.identifier.scopuseid_2-s2.0-34547153230en_HK
dc.identifier.hkuros136113en_HK
dc.identifier.hkuros171463-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547153230&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1311en_HK
dc.identifier.epage1324en_HK
dc.identifier.isiWOS:000249067600005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLee, CL=9277221100en_HK
dc.identifier.scopusauthoridJiang, PP=36147603700en_HK
dc.identifier.scopusauthoridSit, WH=8528923000en_HK
dc.identifier.scopusauthoridWan, JMF=8930305000en_HK

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