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Article: PACAP-related peptide (PRP)-Molecular evolution and potential functions

TitlePACAP-related peptide (PRP)-Molecular evolution and potential functions
Authors
KeywordsEvolution
Growth hormone release
Growth hormone-releasing hormone
Growth hormone-releasing hormone-like peptide
PACAP-related peptide
Pituitary adenylate cyclase-activating polypeptide
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
Citation
Peptides, 2007, v. 28 n. 9, p. 1920-1929 How to Cite?
AbstractPACAP-related peptide (PRP) and PACAP are structurally related peptides that are encoded in the same transcripts. In the past, it was believed that the mammalian PRPs are evolved from GHRHs in non-mammals. With the recent discovery of authentic GHRH and receptor genes in frog and fish, this review aims to (1) coin the name of all GHRH-like peptides in previous literature as PRPs and (2) provide the background for new research direction for PRP in vertebrates. As a goldfish receptor highly specific for PRP with distinct tissue distribution has previously been characterized, it is highly possible that PRP plays a physiological role in non-mammalian vertebrates and the function of PRP has somehow been lost in mammals as a consequence of the loss of its receptor in the genome. This information may provide clues to elucidate functions of PRP in the future. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89261
ISSN
2015 Impact Factor: 2.535
2015 SCImago Journal Rankings: 1.128
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTam, JKVen_HK
dc.contributor.authorLee, LTOen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-06T09:54:36Z-
dc.date.available2010-09-06T09:54:36Z-
dc.date.issued2007en_HK
dc.identifier.citationPeptides, 2007, v. 28 n. 9, p. 1920-1929en_HK
dc.identifier.issn0196-9781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89261-
dc.description.abstractPACAP-related peptide (PRP) and PACAP are structurally related peptides that are encoded in the same transcripts. In the past, it was believed that the mammalian PRPs are evolved from GHRHs in non-mammals. With the recent discovery of authentic GHRH and receptor genes in frog and fish, this review aims to (1) coin the name of all GHRH-like peptides in previous literature as PRPs and (2) provide the background for new research direction for PRP in vertebrates. As a goldfish receptor highly specific for PRP with distinct tissue distribution has previously been characterized, it is highly possible that PRP plays a physiological role in non-mammalian vertebrates and the function of PRP has somehow been lost in mammals as a consequence of the loss of its receptor in the genome. This information may provide clues to elucidate functions of PRP in the future. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptidesen_HK
dc.relation.ispartofPeptidesen_HK
dc.rightsPeptides. Copyright © Elsevier BV.en_HK
dc.subjectEvolutionen_HK
dc.subjectGrowth hormone releaseen_HK
dc.subjectGrowth hormone-releasing hormoneen_HK
dc.subjectGrowth hormone-releasing hormone-like peptideen_HK
dc.subjectPACAP-related peptideen_HK
dc.subjectPituitary adenylate cyclase-activating polypeptideen_HK
dc.titlePACAP-related peptide (PRP)-Molecular evolution and potential functionsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0079-0753&volume=28&spage=1920&epage=1929&date=2007&atitle=PACAP-related+peptide+(PRP)-Molecular+evolution+and+potential+functionsen_HK
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hku.hken_HK
dc.identifier.authorityLee, LTO=rp00727en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.peptides.2007.07.011en_HK
dc.identifier.pmid17714829en_HK
dc.identifier.scopuseid_2-s2.0-34548456352en_HK
dc.identifier.hkuros136117en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548456352&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1920en_HK
dc.identifier.epage1929en_HK
dc.identifier.isiWOS:000250038200038-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTam, JKV=36830083000en_HK
dc.identifier.scopusauthoridLee, LTO=8367269000en_HK
dc.identifier.scopusauthoridChow, BKC=7102826193en_HK

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