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Article: Tyrosinase inhibitory constituents from the roots of Morus nigra: A structure-activity relationship study
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TitleTyrosinase inhibitory constituents from the roots of Morus nigra: A structure-activity relationship study
 
AuthorsZheng, ZP2
Cheng, KW2
Zhu, Q2
Wang, XC1
Lin, ZX3
Wang, M2
 
KeywordsMorus nigra
Phenolic compounds
Tyrosinase inhibition
 
Issue Date2010
 
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau
 
CitationJournal Of Agricultural And Food Chemistry, 2010, v. 58 n. 9, p. 5368-5373 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jf1003607
 
AbstractThe phytochemical profiles of Morus nigra roots and twigs were compared by HPLC with those of the old and young twigs of Morus alba which are known to contain oxyresveratrol and mulberroside A as major components. It was found that M. nigra root extract contains some unknown natural products with potential tyrosinase inhibitory activity. The extract (95% ethanol) of the roots of M. nigra was further investigated in this study. One new compound, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, and twenty-eight known phenolic compounds were isolated. Their structures were identified by mass spectrometry and NMR spectroscopy. Nine compounds, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, steppogenin-7-O-β-d-glucoside, 2,4,2',4'-tetrahydroxychalcone, moracin N, kuwanon H, mulberrofuran G, morachalcone A, oxyresveratrol-3'-O-β-d- glucopyranoside and oxyresveratrol-2-O-β-d-glucopyranoside, showed better tyrosinase inhibitory activities than kojic acid. It was noteworthy that the IC 50 values of 2,4,2',4'-tetrahydroxychalcone and morachalcone A were 757-fold and 328-fold lower than that of kojic acid, respectively, suggesting a great potential for their development as effective natural tyrosinase inhibitors. © 2010 American Chemical Society.
 
ISSN0021-8561
2013 Impact Factor: 3.107
2013 SCImago Journal Rankings: 1.428
 
DOIhttp://dx.doi.org/10.1021/jf1003607
 
ISI Accession Number IDWOS:000277237500023
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZheng, ZP
 
dc.contributor.authorCheng, KW
 
dc.contributor.authorZhu, Q
 
dc.contributor.authorWang, XC
 
dc.contributor.authorLin, ZX
 
dc.contributor.authorWang, M
 
dc.date.accessioned2010-09-06T09:54:35Z
 
dc.date.available2010-09-06T09:54:35Z
 
dc.date.issued2010
 
dc.description.abstractThe phytochemical profiles of Morus nigra roots and twigs were compared by HPLC with those of the old and young twigs of Morus alba which are known to contain oxyresveratrol and mulberroside A as major components. It was found that M. nigra root extract contains some unknown natural products with potential tyrosinase inhibitory activity. The extract (95% ethanol) of the roots of M. nigra was further investigated in this study. One new compound, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, and twenty-eight known phenolic compounds were isolated. Their structures were identified by mass spectrometry and NMR spectroscopy. Nine compounds, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, steppogenin-7-O-β-d-glucoside, 2,4,2',4'-tetrahydroxychalcone, moracin N, kuwanon H, mulberrofuran G, morachalcone A, oxyresveratrol-3'-O-β-d- glucopyranoside and oxyresveratrol-2-O-β-d-glucopyranoside, showed better tyrosinase inhibitory activities than kojic acid. It was noteworthy that the IC 50 values of 2,4,2',4'-tetrahydroxychalcone and morachalcone A were 757-fold and 328-fold lower than that of kojic acid, respectively, suggesting a great potential for their development as effective natural tyrosinase inhibitors. © 2010 American Chemical Society.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Agricultural And Food Chemistry, 2010, v. 58 n. 9, p. 5368-5373 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jf1003607
 
dc.identifier.doihttp://dx.doi.org/10.1021/jf1003607
 
dc.identifier.eissn1520-5118
 
dc.identifier.epage5373
 
dc.identifier.hkuros170235
 
dc.identifier.isiWOS:000277237500023
 
dc.identifier.issn0021-8561
2013 Impact Factor: 3.107
2013 SCImago Journal Rankings: 1.428
 
dc.identifier.issue9
 
dc.identifier.openurl
 
dc.identifier.pmid20297841
 
dc.identifier.scopuseid_2-s2.0-77952224236
 
dc.identifier.spage5368
 
dc.identifier.urihttp://hdl.handle.net/10722/89260
 
dc.identifier.volume58
 
dc.languageeng
 
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Agricultural and Food Chemistry
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshMorus nigra
 
dc.subject.meshPhenolic compounds
 
dc.subject.meshTyrosinase inhibition
 
dc.subjectMorus nigra
 
dc.subjectPhenolic compounds
 
dc.subjectTyrosinase inhibition
 
dc.titleTyrosinase inhibitory constituents from the roots of Morus nigra: A structure-activity relationship study
 
dc.typeArticle
 
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Author Affiliations
  1. Hainan Provincial Institute for Drug Control
  2. The University of Hong Kong
  3. Chinese University of Hong Kong