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Article: Tyrosinase inhibitory constituents from the roots of Morus nigra: A structure-activity relationship study

TitleTyrosinase inhibitory constituents from the roots of Morus nigra: A structure-activity relationship study
Authors
KeywordsMorus nigra
Phenolic compounds
Tyrosinase inhibition
Issue Date2010
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau
Citation
Journal Of Agricultural And Food Chemistry, 2010, v. 58 n. 9, p. 5368-5373 How to Cite?
AbstractThe phytochemical profiles of Morus nigra roots and twigs were compared by HPLC with those of the old and young twigs of Morus alba which are known to contain oxyresveratrol and mulberroside A as major components. It was found that M. nigra root extract contains some unknown natural products with potential tyrosinase inhibitory activity. The extract (95% ethanol) of the roots of M. nigra was further investigated in this study. One new compound, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, and twenty-eight known phenolic compounds were isolated. Their structures were identified by mass spectrometry and NMR spectroscopy. Nine compounds, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, steppogenin-7-O-β-d-glucoside, 2,4,2',4'-tetrahydroxychalcone, moracin N, kuwanon H, mulberrofuran G, morachalcone A, oxyresveratrol-3'-O-β-d- glucopyranoside and oxyresveratrol-2-O-β-d-glucopyranoside, showed better tyrosinase inhibitory activities than kojic acid. It was noteworthy that the IC 50 values of 2,4,2',4'-tetrahydroxychalcone and morachalcone A were 757-fold and 328-fold lower than that of kojic acid, respectively, suggesting a great potential for their development as effective natural tyrosinase inhibitors. © 2010 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/89260
ISSN
2015 Impact Factor: 2.857
2015 SCImago Journal Rankings: 1.246
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, ZPen_HK
dc.contributor.authorCheng, KWen_HK
dc.contributor.authorZhu, Qen_HK
dc.contributor.authorWang, XCen_HK
dc.contributor.authorLin, ZXen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2010-09-06T09:54:35Z-
dc.date.available2010-09-06T09:54:35Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Agricultural And Food Chemistry, 2010, v. 58 n. 9, p. 5368-5373en_HK
dc.identifier.issn0021-8561en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89260-
dc.description.abstractThe phytochemical profiles of Morus nigra roots and twigs were compared by HPLC with those of the old and young twigs of Morus alba which are known to contain oxyresveratrol and mulberroside A as major components. It was found that M. nigra root extract contains some unknown natural products with potential tyrosinase inhibitory activity. The extract (95% ethanol) of the roots of M. nigra was further investigated in this study. One new compound, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, and twenty-eight known phenolic compounds were isolated. Their structures were identified by mass spectrometry and NMR spectroscopy. Nine compounds, 5'-geranyl-5,7,2',4'-tetrahydroxyflavone, steppogenin-7-O-β-d-glucoside, 2,4,2',4'-tetrahydroxychalcone, moracin N, kuwanon H, mulberrofuran G, morachalcone A, oxyresveratrol-3'-O-β-d- glucopyranoside and oxyresveratrol-2-O-β-d-glucopyranoside, showed better tyrosinase inhibitory activities than kojic acid. It was noteworthy that the IC 50 values of 2,4,2',4'-tetrahydroxychalcone and morachalcone A were 757-fold and 328-fold lower than that of kojic acid, respectively, suggesting a great potential for their development as effective natural tyrosinase inhibitors. © 2010 American Chemical Society.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcauen_HK
dc.relation.ispartofJournal of Agricultural and Food Chemistryen_HK
dc.subjectMorus nigraen_HK
dc.subjectPhenolic compoundsen_HK
dc.subjectTyrosinase inhibitionen_HK
dc.subject.meshMorus nigra-
dc.subject.meshPhenolic compounds-
dc.subject.meshTyrosinase inhibition-
dc.titleTyrosinase inhibitory constituents from the roots of Morus nigra: A structure-activity relationship studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-8561&volume=58&issue=9&spage=5368&epage=5373&date=2010&atitle=Tyrosinase+inhibitory+constituents+from+the+roots+of+Morus+nigra:+a+structure-activity+relationship+studyen_HK
dc.identifier.emailWang, M: mfwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00800en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/jf1003607en_HK
dc.identifier.pmid20297841-
dc.identifier.scopuseid_2-s2.0-77952224236en_HK
dc.identifier.hkuros170235en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952224236&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume58en_HK
dc.identifier.issue9en_HK
dc.identifier.spage5368en_HK
dc.identifier.epage5373en_HK
dc.identifier.eissn1520-5118-
dc.identifier.isiWOS:000277237500023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZheng, ZP=8451746600en_HK
dc.identifier.scopusauthoridCheng, KW=12141247000en_HK
dc.identifier.scopusauthoridZhu, Q=54909442800en_HK
dc.identifier.scopusauthoridWang, XC=35206803200en_HK
dc.identifier.scopusauthoridLin, ZX=26433004200en_HK
dc.identifier.scopusauthoridWang, M=7406691844en_HK

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