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Article: Evolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events

TitleEvolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment events
Authors
KeywordsH1N2 influenza
Local clock
Molecular clock
Molecular dating
Multiple reassortments
Synonymous substitution
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/virusres
Citation
Virus Research, 2008, v. 131 n. 2, p. 271-278 How to Cite?
AbstractA novel H1N2 swine influenza A virus emerged in Europe since 1994. Previous phylogenetic analyses revealed that its genome segments were derived from H1N1 human virus, H3N2 human virus and avian-like H1N1/H3N2 swine virus, indicating the possibility of multiple reassortments events. However, dates of these reassortment events have not been investigated systematically. In this study, we used both global and local molecular clock concepts in a maximum likelihood framework to extrapolate the times of origins of the genome segments in European H1N2 swine viruses, and deduced that novel neuraminidase, hemagglutinin and other internal protein genes were introduced to the European H1N2 lineage at the 1970s, early 1980s and late 1980s, respectively through reassortments. Furthermore, in light of the evolutionary timescale reconstructed for the H1N2 viruses, we argue that further reassortments, in addition to those responsible for the introductions of novel genome segments, might have also occurred among the viruses prior to the outbreaks arose in United Kingdom at 1994. Our results confirm that the viral genes of various origins have stably maintained in swine population for many years before the multiple genetic reassortant was detected. Our evolutionary analyses also suggested that the HA and NA genes evolved in a significantly higher rate of synonymous substitutions after they were introduced from human to swine and established the European H1N2 swine lineage. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89250
ISSN
2015 Impact Factor: 2.526
2015 SCImago Journal Rankings: 1.259
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, TYen_HK
dc.contributor.authorHon, CCen_HK
dc.contributor.authorWang, Zen_HK
dc.contributor.authorHui, RKHen_HK
dc.contributor.authorZeng, Fen_HK
dc.contributor.authorLeung, FCCen_HK
dc.date.accessioned2010-09-06T09:54:27Z-
dc.date.available2010-09-06T09:54:27Z-
dc.date.issued2008en_HK
dc.identifier.citationVirus Research, 2008, v. 131 n. 2, p. 271-278en_HK
dc.identifier.issn0168-1702en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89250-
dc.description.abstractA novel H1N2 swine influenza A virus emerged in Europe since 1994. Previous phylogenetic analyses revealed that its genome segments were derived from H1N1 human virus, H3N2 human virus and avian-like H1N1/H3N2 swine virus, indicating the possibility of multiple reassortments events. However, dates of these reassortment events have not been investigated systematically. In this study, we used both global and local molecular clock concepts in a maximum likelihood framework to extrapolate the times of origins of the genome segments in European H1N2 swine viruses, and deduced that novel neuraminidase, hemagglutinin and other internal protein genes were introduced to the European H1N2 lineage at the 1970s, early 1980s and late 1980s, respectively through reassortments. Furthermore, in light of the evolutionary timescale reconstructed for the H1N2 viruses, we argue that further reassortments, in addition to those responsible for the introductions of novel genome segments, might have also occurred among the viruses prior to the outbreaks arose in United Kingdom at 1994. Our results confirm that the viral genes of various origins have stably maintained in swine population for many years before the multiple genetic reassortant was detected. Our evolutionary analyses also suggested that the HA and NA genes evolved in a significantly higher rate of synonymous substitutions after they were introduced from human to swine and established the European H1N2 swine lineage. © 2007 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/virusresen_HK
dc.relation.ispartofVirus Researchen_HK
dc.subjectH1N2 influenzaen_HK
dc.subjectLocal clocken_HK
dc.subjectMolecular clocken_HK
dc.subjectMolecular datingen_HK
dc.subjectMultiple reassortmentsen_HK
dc.subjectSynonymous substitutionen_HK
dc.subject.meshAmino Acid Substitution-
dc.subject.meshEvolution, Molecular-
dc.subject.meshInfluenza A Virus, H1N1 Subtype - genetics - isolation and purification-
dc.subject.meshOrthomyxoviridae Infections - veterinary - virology-
dc.subject.meshSwine Diseases - virology-
dc.titleEvolutionary analyses of European H1N2 swine influenza A virus by placing timestamps on the multiple reassortment eventsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-1702&volume=131&issue=2&spage=271&epage=278&date=2008&atitle=Evolutionary+analyses+of+European+H1N2+swine+influenza+A+virus+by+placing+timestamps+on+the+multiple+reassortment+eventsen_HK
dc.identifier.emailHui, RKH: rkhhui@hkucc.hku.hken_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityHui, RKH=rp00711en_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.virusres.2007.08.012en_HK
dc.identifier.pmid17936394-
dc.identifier.scopuseid_2-s2.0-38649137252en_HK
dc.identifier.hkuros166184en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38649137252&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume131en_HK
dc.identifier.issue2en_HK
dc.identifier.spage271en_HK
dc.identifier.epage278en_HK
dc.identifier.isiWOS:000253786200018-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLam, TY=14527268100en_HK
dc.identifier.scopusauthoridHon, CC=7003617137en_HK
dc.identifier.scopusauthoridWang, Z=14033548900en_HK
dc.identifier.scopusauthoridHui, RKH=7103304764en_HK
dc.identifier.scopusauthoridZeng, F=7202911544en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK

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