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Article: A longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothers

TitleA longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothers
Authors
KeywordsAflatoxin M1
Breast milk
Egypt
Seasonality
Issue Date2007
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/foodchemtox
Citation
Food And Chemical Toxicology, 2007, v. 45 n. 7, p. 1210-1215 How to Cite?
AbstractAflatoxins are potent toxins and carcinogens which can be excreted in the milk of exposed lactating mothers mainly in the form of aflatoxin M1 (AFM1). We previously evaluated the level and frequency of AFM1 in breast milk in a group of Egyptian mothers attending the New El-Qalyub Hospital, Qalyubiyah governorate, Egypt. In this study, fifty of those women who were AFM1 positive were revisited monthly for 12 months to assess the temporal variation in breast milk AFM1. AFM1 was detected in 248 of 443 (56%) samples. In a multilevel model of the data there was a highly significant (p < 0.001) effect of month of sampling on the frequency of AFM1 detection with summer months having the highest frequency (>80%) and winter months the lowest frequency (<20%) of detection. AFM1 was observed most frequently in June [OR 63, 95% CI (7.6, 522)]. The level of AFM1 detection also followed this seasonal pattern with highest mean level in July (64 pg/ml milk, range 6.3-497 pg/ml milk) and the lowest mean level in January (8 pg/ml milk, range 4.2-108 pg/ml milk). The duration of lactation [p = 0.0035, OR = 1.08, 95% CI (1.02, 1.13)], and peanut consumption [p = 0.06, OR = 1.69, 95% CI (0.9, 2.9)] also contributed to the model. The identification and understanding of factors determining the presence of toxicants in human milk is important and may provide a knowledge driven basis for controlling the transfer of chemicals to infants. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89244
ISSN
2015 Impact Factor: 3.584
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPolychronaki, Nen_HK
dc.contributor.authorWest, RMen_HK
dc.contributor.authorTurner, PCen_HK
dc.contributor.authorAmra, Hen_HK
dc.contributor.authorAbdelWahhab, Men_HK
dc.contributor.authorMykkänen, Hen_HK
dc.contributor.authorElNezami, Hen_HK
dc.date.accessioned2010-09-06T09:54:23Z-
dc.date.available2010-09-06T09:54:23Z-
dc.date.issued2007en_HK
dc.identifier.citationFood And Chemical Toxicology, 2007, v. 45 n. 7, p. 1210-1215en_HK
dc.identifier.issn0278-6915en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89244-
dc.description.abstractAflatoxins are potent toxins and carcinogens which can be excreted in the milk of exposed lactating mothers mainly in the form of aflatoxin M1 (AFM1). We previously evaluated the level and frequency of AFM1 in breast milk in a group of Egyptian mothers attending the New El-Qalyub Hospital, Qalyubiyah governorate, Egypt. In this study, fifty of those women who were AFM1 positive were revisited monthly for 12 months to assess the temporal variation in breast milk AFM1. AFM1 was detected in 248 of 443 (56%) samples. In a multilevel model of the data there was a highly significant (p < 0.001) effect of month of sampling on the frequency of AFM1 detection with summer months having the highest frequency (>80%) and winter months the lowest frequency (<20%) of detection. AFM1 was observed most frequently in June [OR 63, 95% CI (7.6, 522)]. The level of AFM1 detection also followed this seasonal pattern with highest mean level in July (64 pg/ml milk, range 6.3-497 pg/ml milk) and the lowest mean level in January (8 pg/ml milk, range 4.2-108 pg/ml milk). The duration of lactation [p = 0.0035, OR = 1.08, 95% CI (1.02, 1.13)], and peanut consumption [p = 0.06, OR = 1.69, 95% CI (0.9, 2.9)] also contributed to the model. The identification and understanding of factors determining the presence of toxicants in human milk is important and may provide a knowledge driven basis for controlling the transfer of chemicals to infants. © 2007 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/foodchemtoxen_HK
dc.relation.ispartofFood and Chemical Toxicologyen_HK
dc.subjectAflatoxin M1en_HK
dc.subjectBreast milken_HK
dc.subjectEgypten_HK
dc.subjectSeasonalityen_HK
dc.titleA longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-6915&volume=45&spage=1210&epage=5&date=2007&atitle=A+longitudinal+assessment+of+aflatoxin+M1+excretion+in breast+milk+of+selected+Egyptian+mothers.en_HK
dc.identifier.emailElNezami, H: elnezami@hkucc.hku.hken_HK
dc.identifier.authorityElNezami, H=rp00694en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.fct.2007.01.001en_HK
dc.identifier.pmid17306915-
dc.identifier.scopuseid_2-s2.0-34247185942en_HK
dc.identifier.hkuros151544en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247185942&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1210en_HK
dc.identifier.epage1215en_HK
dc.identifier.isiWOS:000247537800016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridPolychronaki, N=6505944468en_HK
dc.identifier.scopusauthoridWest, RM=7402395730en_HK
dc.identifier.scopusauthoridTurner, PC=7402096074en_HK
dc.identifier.scopusauthoridAmra, H=14014308000en_HK
dc.identifier.scopusauthoridAbdelWahhab, M=55406849000en_HK
dc.identifier.scopusauthoridMykkänen, H=7003915985en_HK
dc.identifier.scopusauthoridElNezami, H=6603690577en_HK
dc.identifier.citeulike3836761-

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