File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Evidence of the recombinant origin of a bat Severe Acute Respiratory Syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus

TitleEvidence of the recombinant origin of a bat Severe Acute Respiratory Syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus
Authors
Issue Date2008
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2008, v. 82 n. 4, p. 1819-1826 How to Cite?
AbstractBats have been identified as the natural reservoir of severe acute respiratory syndrome (SARS)-like and SARS coronaviruses (SLCoV and SCoV). However, previous studies suggested that none of the currently sampled bat SLCoVs is the descendant of the direct ancestor of SCoV, based on their relatively distant phylogenetic relationship. In this study, evidence of the recombinant origin of the genome of a bat SLCoV is demonstrated. We identified a potential recombination breakpoint immediately after the consensus intergenic sequence between open reading frame 1 and the S coding region, suggesting the replication intermediates may participate in the recombination event, as previously speculated for other CoVs. Phylogenetic analysis of its parental regions suggests the presence of an uncharacterized SLCoV lineage that is phylogenetically closer to SCoVs than any of the currently sampled bat SLCoVs. Using various Bayesian molecular-clock models, interspecies transfer of this SLCoV lineage from bats to the amplifying host (e.g., civets) was estimated to have happened a median of 4.08 years before the SARS outbreak. Based on this relatively short window period, we speculate that this uncharacterized SLCoV lineage may contain the direct ancestor of SCoV. This study sheds light on the possible host bat species of the direct ancestor of SCoV, providing valuable information on the scope and focus of surveillance for the origin of SCoV. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/89227
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHon, CCen_HK
dc.contributor.authorLam, TYen_HK
dc.contributor.authorShi, ZLen_HK
dc.contributor.authorDrummond, AJen_HK
dc.contributor.authorYip, CWen_HK
dc.contributor.authorZeng, Fen_HK
dc.contributor.authorLam, PYen_HK
dc.contributor.authorLeung, FCCen_HK
dc.date.accessioned2010-09-06T09:54:09Z-
dc.date.available2010-09-06T09:54:09Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Virology, 2008, v. 82 n. 4, p. 1819-1826en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/89227-
dc.description.abstractBats have been identified as the natural reservoir of severe acute respiratory syndrome (SARS)-like and SARS coronaviruses (SLCoV and SCoV). However, previous studies suggested that none of the currently sampled bat SLCoVs is the descendant of the direct ancestor of SCoV, based on their relatively distant phylogenetic relationship. In this study, evidence of the recombinant origin of the genome of a bat SLCoV is demonstrated. We identified a potential recombination breakpoint immediately after the consensus intergenic sequence between open reading frame 1 and the S coding region, suggesting the replication intermediates may participate in the recombination event, as previously speculated for other CoVs. Phylogenetic analysis of its parental regions suggests the presence of an uncharacterized SLCoV lineage that is phylogenetically closer to SCoVs than any of the currently sampled bat SLCoVs. Using various Bayesian molecular-clock models, interspecies transfer of this SLCoV lineage from bats to the amplifying host (e.g., civets) was estimated to have happened a median of 4.08 years before the SARS outbreak. Based on this relatively short window period, we speculate that this uncharacterized SLCoV lineage may contain the direct ancestor of SCoV. This study sheds light on the possible host bat species of the direct ancestor of SCoV, providing valuable information on the scope and focus of surveillance for the origin of SCoV. Copyright © 2008, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.subject.meshChiroptera - virology-
dc.subject.meshGenome, Viral - genetics-
dc.subject.meshModels, Genetic-
dc.subject.meshPhylogeny-
dc.subject.meshSARS Virus - classification - genetics - isolation and purification-
dc.titleEvidence of the recombinant origin of a bat Severe Acute Respiratory Syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=82&issue=4&spage=1819&epage=1826&date=2008&atitle=Evidence+of+the+recombinant+origin+of+a+bat+severe+acute+respiratory+syndrome+(SARS)-like+coronavirus+and+its+implications+on+the+direct+ancestor+of+SARS+coronavirusen_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.01926-07en_HK
dc.identifier.pmid18057240-
dc.identifier.pmcidPMC2258724-
dc.identifier.scopuseid_2-s2.0-38849104932en_HK
dc.identifier.hkuros167647en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38849104932&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1819en_HK
dc.identifier.epage1826en_HK
dc.identifier.isiWOS:000252909300018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHon, CC=7003617137en_HK
dc.identifier.scopusauthoridLam, TY=14527268100en_HK
dc.identifier.scopusauthoridShi, ZL=7403733955en_HK
dc.identifier.scopusauthoridDrummond, AJ=26643297100en_HK
dc.identifier.scopusauthoridYip, CW=7101665559en_HK
dc.identifier.scopusauthoridZeng, F=7202911544en_HK
dc.identifier.scopusauthoridLam, PY=36847488300en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats