File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Alox12 gene is associated with the onset of natural menopause in white women

TitleAlox12 gene is associated with the onset of natural menopause in white women
Authors
KeywordsAge at natural menopause
ALOX12
Association
Haplotypes
Polymorphisms
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.com
Citation
Menopause, 2010, v. 17 n. 1, p. 152-156 How to Cite?
AbstractObjective: Natural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many postmenopausal systemic disorders and may thus influence life expectancy. Age at natural menopause (ANM) is largely determined genetically, but a list of candidate genes is far from complete. This study investigated the ALOX12 gene for its possible association with ANM. Methods: Six single-nucleotide polymorphisms (SNPs) of the gene (rs9904779, rs2073438, rs11571340, rs434473, rs2307214, and rs312462) were genotyped in a random sample of 210 unrelated white women. The SNPs and common haplotypes were then analyzed for their association with ANM. Smoking, alcohol consumption, and duration of breast-feeding were used as covariates. Results: Two SNPs, rs9904779 and rs434473 (encodes a replacement of asparagine by serine in the protein), were significantly associated with ANM (P = 0.022 and 0.033, respectively). The minor alleles of both SNPs seem to promote about 1.3-to 1.5-year earlier menopause and confer a 1.6 to 1.8 times higher risk for early menopause. All SNPs indicated significant or nearly significant interactions with alcohol use and duration of breast-feeding. Five common haplotypes were also associated with ANM. Conclusions: The ALOX12 gene seems to be associated with the timing of natural menopause in white women. © 2010 by The North American Menopause Society.
Persistent Identifierhttp://hdl.handle.net/10722/89198
ISSN
2015 Impact Factor: 3.172
2015 SCImago Journal Rankings: 1.270
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of HealthR01 AR050496
K01 AR02170-01
R01 AR45349-01
R01 GM60402-01AI
State of NebraskaLB595
National Science Foundation of China
Huo Ying Dong Education Foundation
HuNan Province
Xi'an Jiaotong University
Ministry of Education of China
Funding Information:

Financial support for this study was provided by the National Institutes of Health (grants R01 AR050496, K01 AR02170-01, R01 AR45349-01, and R01 GM60402-01AI), the State of Nebraska (grant LB595) the National Science Foundation of China, Huo Ying Dong Education Foundation, HuNan Province, Xi'an Jiaotong University, and the Ministry of Education of China.

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Pen_HK
dc.contributor.authorLu, Yen_HK
dc.contributor.authorRecker, RRen_HK
dc.contributor.authorDeng, HWen_HK
dc.contributor.authorDvornyk, Ven_HK
dc.date.accessioned2010-09-06T09:53:46Z-
dc.date.available2010-09-06T09:53:46Z-
dc.date.issued2010en_HK
dc.identifier.citationMenopause, 2010, v. 17 n. 1, p. 152-156en_HK
dc.identifier.issn1072-3714en_HK
dc.identifier.urihttp://hdl.handle.net/10722/89198-
dc.description.abstractObjective: Natural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many postmenopausal systemic disorders and may thus influence life expectancy. Age at natural menopause (ANM) is largely determined genetically, but a list of candidate genes is far from complete. This study investigated the ALOX12 gene for its possible association with ANM. Methods: Six single-nucleotide polymorphisms (SNPs) of the gene (rs9904779, rs2073438, rs11571340, rs434473, rs2307214, and rs312462) were genotyped in a random sample of 210 unrelated white women. The SNPs and common haplotypes were then analyzed for their association with ANM. Smoking, alcohol consumption, and duration of breast-feeding were used as covariates. Results: Two SNPs, rs9904779 and rs434473 (encodes a replacement of asparagine by serine in the protein), were significantly associated with ANM (P = 0.022 and 0.033, respectively). The minor alleles of both SNPs seem to promote about 1.3-to 1.5-year earlier menopause and confer a 1.6 to 1.8 times higher risk for early menopause. All SNPs indicated significant or nearly significant interactions with alcohol use and duration of breast-feeding. Five common haplotypes were also associated with ANM. Conclusions: The ALOX12 gene seems to be associated with the timing of natural menopause in white women. © 2010 by The North American Menopause Society.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.menopausejournal.comen_HK
dc.relation.ispartofMenopauseen_HK
dc.rightsThis is a non-final version of an article published in final form in Menopause, 2010, v. 17 n. 1, p. 152-156en_HK
dc.subjectAge at natural menopauseen_HK
dc.subjectALOX12en_HK
dc.subjectAssociationen_HK
dc.subjectHaplotypesen_HK
dc.subjectPolymorphismsen_HK
dc.subject.meshAging - genetics-
dc.subject.meshArachidonate 12-Lipoxygenase - genetics-
dc.subject.meshEuropean Continental Ancestry Group-
dc.subject.meshMenopause - genetics-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleAlox12 gene is associated with the onset of natural menopause in white womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1072-3714&volume=17&issue=1&spage=152&epage=156&date=2010&atitle=ALOX12+gene+is+associated+with+the+onset+of+natural+menopause+in+white+womenen_HK
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_HK
dc.identifier.authorityDvornyk, V=rp00693en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1097/gme.0b013e3181b63c68en_HK
dc.identifier.pmid20061896-
dc.identifier.pmcidPMC2927106-
dc.identifier.scopuseid_2-s2.0-74549129423en_HK
dc.identifier.hkuros168554en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-74549129423&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue1en_HK
dc.identifier.spage152en_HK
dc.identifier.epage156en_HK
dc.identifier.eissn1530-0374-
dc.identifier.isiWOS:000273517400025-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, P=7404618030en_HK
dc.identifier.scopusauthoridLu, Y=26643076900en_HK
dc.identifier.scopusauthoridRecker, RR=7007086875en_HK
dc.identifier.scopusauthoridDeng, HW=7401775190en_HK
dc.identifier.scopusauthoridDvornyk, V=6701789786en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats