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Article: Prevalence of antibodies against avian influenza A (H5N1) virus among cullers and poultry workers in Ho Chi Minh City, 2005

TitlePrevalence of antibodies against avian influenza A (H5N1) virus among cullers and poultry workers in Ho Chi Minh City, 2005
Authors
Issue Date2009
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2009, v. 4 n. 11 How to Cite?
AbstractBackground: Between 2003 and 2005, highly pathogenic avian influenza A (H5N1) viruses caused large scale outbreaks in poultry in the Ho Chi Minh City area in Vietnam. We studied the prevalence of antibodies against H5N1 in poultry workers and cullers who were active in the program in Ho Chi Minh City in 2004 and 2005. Methodology/Principal Findings: Single sera from 500 poultry workers and poultry cullers exposed to infected birds were tested for antibodies to avian influenza H5N1, using microneutralization assays and hemagglutination inhibition assay with horse blood. All sera tested negative using microneutralization tests. Three samples showed a 1:80 titer in the hemagglutination inhibition assay. Conclusions/Significance: This study provides additional support for the low transmissibility of clade 1 H5N1 to humans, but limited transmission to highly exposed persons cannot be excluded given the presence of low antibody titers in some individuals. © 2009 Schultsz et al.
Persistent Identifierhttp://hdl.handle.net/10722/88847
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Wellcome Trust, UK
Area of Excellence Scheme of the University Grants Committee, Hong KongAoE/M-12/06
Funding Information:

This study was supported by the Wellcome Trust, UK, and the Area of Excellence Scheme of the University Grants Committee, Hong Kong (Grant AoE/M-12/06). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorSchultsz, Cen_HK
dc.contributor.authorVan Dung, Nen_HK
dc.contributor.authorHai, LTen_HK
dc.contributor.authorQuang Ha, Den_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorLim, Wen_HK
dc.contributor.authorGarcia, JMen_HK
dc.contributor.authorDac Tho, Nen_HK
dc.contributor.authorThi Hoang Lan, Nen_HK
dc.contributor.authorTho, HHen_HK
dc.contributor.authorThao, PXen_HK
dc.contributor.authorvan Doorn, HRen_HK
dc.contributor.authorVan Vinh Chau, Nen_HK
dc.contributor.authorFarrar, Jen_HK
dc.contributor.authorde Jong, MDen_HK
dc.date.accessioned2010-09-06T09:48:54Z-
dc.date.available2010-09-06T09:48:54Z-
dc.date.issued2009en_HK
dc.identifier.citationPlos One, 2009, v. 4 n. 11en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88847-
dc.description.abstractBackground: Between 2003 and 2005, highly pathogenic avian influenza A (H5N1) viruses caused large scale outbreaks in poultry in the Ho Chi Minh City area in Vietnam. We studied the prevalence of antibodies against H5N1 in poultry workers and cullers who were active in the program in Ho Chi Minh City in 2004 and 2005. Methodology/Principal Findings: Single sera from 500 poultry workers and poultry cullers exposed to infected birds were tested for antibodies to avian influenza H5N1, using microneutralization assays and hemagglutination inhibition assay with horse blood. All sera tested negative using microneutralization tests. Three samples showed a 1:80 titer in the hemagglutination inhibition assay. Conclusions/Significance: This study provides additional support for the low transmissibility of clade 1 H5N1 to humans, but limited transmission to highly exposed persons cannot be excluded given the presence of low antibody titers in some individuals. © 2009 Schultsz et al.en_HK
dc.languageengen_HK
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBirds - immunology - virology-
dc.subject.meshHemagglutination Inhibition Tests-
dc.subject.meshInfluenza A Virus, H5N1 Subtype - immunology-
dc.subject.meshInfluenza in Birds - immunology-
dc.subject.meshInfluenza, Human - immunology-
dc.titlePrevalence of antibodies against avian influenza A (H5N1) virus among cullers and poultry workers in Ho Chi Minh City, 2005en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1932-6203&volume=4&issue=11, article no. e7948&spage=&epage=&date=2009&atitle=Prevalence+of+antibodies+against+avian+Influenza+A+(H5N1)+virus+among+cullers+and+poultry+workers+in+Ho+Chi+Minh+City,+2005en_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0007948en_HK
dc.identifier.pmid19956765-
dc.identifier.pmcidPMC2776305-
dc.identifier.scopuseid_2-s2.0-71049131213en_HK
dc.identifier.hkuros168192en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-71049131213&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue11en_HK
dc.identifier.isiWOS:000272827300007-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridSchultsz, C=6603560235en_HK
dc.identifier.scopusauthoridVan Dung, N=6507812952en_HK
dc.identifier.scopusauthoridHai, LT=35083541900en_HK
dc.identifier.scopusauthoridQuang Ha, D=15851466100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridLim, W=7202378277en_HK
dc.identifier.scopusauthoridGarcia, JM=16202601400en_HK
dc.identifier.scopusauthoridDac Tho, N=35331767700en_HK
dc.identifier.scopusauthoridThi Hoang Lan, N=35333018800en_HK
dc.identifier.scopusauthoridTho, HH=55302893300en_HK
dc.identifier.scopusauthoridThao, PX=35333000700en_HK
dc.identifier.scopusauthoridvan Doorn, HR=6701433317en_HK
dc.identifier.scopusauthoridVan Vinh Chau, N=24170234100en_HK
dc.identifier.scopusauthoridFarrar, J=7103292979en_HK
dc.identifier.scopusauthoridde Jong, MD=7201366838en_HK

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