File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Trisomy 21 as the sole acquired karyotypic abnormality in acute myeloid leukemia and myelodysplastic syndrome

TitleTrisomy 21 as the sole acquired karyotypic abnormality in acute myeloid leukemia and myelodysplastic syndrome
Authors
Issue Date1999
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukres
Citation
Leukemia Research, 1999, v. 23 n. 11, p. 1079-1083 How to Cite?
AbstractWe report five cases of myeloid disorders in which trisomy 21 (+ 21) was found as the sole acquired karyotypic abnormality, comprising two cases of acute myeloid leukemia (AML) and three cases of myelodysplastic syndrome (MDS). In this series, MDS patients with + 21 presented as high grade disease, which included two cases of refractory anemia with excess of blasts (RAEB) and one case of refractory anemia with excess of blasts in transformation (RAEBt), and showed rapid disease progression. Significant thrombocytopenia was observed in all three patients, and bone marrow examination showed a marked reduction in megakaryocytes. AML patients with + 21 included one case each of AML-M2 and M4. Despite the poor prognosis reported in AML patients with + 21 as the sole abnormality, the patient in our series who was able to complete intensive treatment was cured of disease. The role of + 21 in leukemogenesis is reviewed.
Persistent Identifierhttp://hdl.handle.net/10722/88805
ISSN
2015 Impact Factor: 2.606
2015 SCImago Journal Rankings: 1.043
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorChan, JCWen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorMa, SKen_HK
dc.date.accessioned2010-09-06T09:48:13Z-
dc.date.available2010-09-06T09:48:13Z-
dc.date.issued1999en_HK
dc.identifier.citationLeukemia Research, 1999, v. 23 n. 11, p. 1079-1083en_HK
dc.identifier.issn0145-2126en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88805-
dc.description.abstractWe report five cases of myeloid disorders in which trisomy 21 (+ 21) was found as the sole acquired karyotypic abnormality, comprising two cases of acute myeloid leukemia (AML) and three cases of myelodysplastic syndrome (MDS). In this series, MDS patients with + 21 presented as high grade disease, which included two cases of refractory anemia with excess of blasts (RAEB) and one case of refractory anemia with excess of blasts in transformation (RAEBt), and showed rapid disease progression. Significant thrombocytopenia was observed in all three patients, and bone marrow examination showed a marked reduction in megakaryocytes. AML patients with + 21 included one case each of AML-M2 and M4. Despite the poor prognosis reported in AML patients with + 21 as the sole abnormality, the patient in our series who was able to complete intensive treatment was cured of disease. The role of + 21 in leukemogenesis is reviewed.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukresen_HK
dc.relation.ispartofLeukemia Researchen_HK
dc.subject.meshAcute Diseaseen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBone Marrow - pathologyen_HK
dc.subject.meshDown Syndromeen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshLeukemia, Myeloid - genetics - pathology - therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMyelodysplastic Syndromes - genetics - pathologyen_HK
dc.titleTrisomy 21 as the sole acquired karyotypic abnormality in acute myeloid leukemia and myelodysplastic syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0145-2126&volume=23&spage=1079&epage=1083&date=1999&atitle=Trisomy+21+as+the+sole+acquired+karyotypic+abnormality+in+acute+myeloid+leukemia+and+myelodysplastic+syndromeen_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0145-2126(99)00117-4en_HK
dc.identifier.pmid10576514-
dc.identifier.scopuseid_2-s2.0-0032832959en_HK
dc.identifier.hkuros50812en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032832959&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1079en_HK
dc.identifier.epage1083en_HK
dc.identifier.isiWOS:000083327100015-
dc.publisher.placeUnited Kingdomen_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats