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Article: p53 intron 2 genotypes detected in normal specimens and lung carcinomas in Hong Kong

Titlep53 intron 2 genotypes detected in normal specimens and lung carcinomas in Hong Kong
Authors
KeywordsExon 2
Hong Kong
Intron 2
Lung carcinoma
Mutations
p53
Polymorphisms
Issue Date1998
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 1998, v. 5 n. 5, p. 1265-1267 How to Cite?
AbstractPrevious studies suggest that the polymorphic p53 intron 2 displays a high frequency of mutations, occurring with different frequencies in tumor tissues versus peripheral blood of lung cancer patients as compared to healthy individuals. We evaluated the significance of these polymorphisms and mutations utilizing matched triple specimens from the lung tumor, normal lung tissue, and peripheral blood of cancer patients. Identical genotypes were observed in normal tissues and blood, while 4 mutations were observed in tumors. The A1 allelic frequency was increased in the adenocarcinoma tissues as compared to normal tissues. Two p53 exon 2 polymorphisms were detected, appearing with equal frequencies among cancer patients and healthy individuals. The p53 intron 2 polymorphic locus is a hot spot for mutations in Hong Kong lung cancer patients.
Persistent Identifierhttp://hdl.handle.net/10722/88790
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGe, Hen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorLee, Jen_HK
dc.contributor.authorFu, KHen_HK
dc.contributor.authorYew, WWen_HK
dc.contributor.authorLung, MLIen_HK
dc.date.accessioned2010-09-06T09:48:02Z-
dc.date.available2010-09-06T09:48:02Z-
dc.date.issued1998en_HK
dc.identifier.citationOncology Reports, 1998, v. 5 n. 5, p. 1265-1267en_HK
dc.identifier.issn1021-335Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/88790-
dc.description.abstractPrevious studies suggest that the polymorphic p53 intron 2 displays a high frequency of mutations, occurring with different frequencies in tumor tissues versus peripheral blood of lung cancer patients as compared to healthy individuals. We evaluated the significance of these polymorphisms and mutations utilizing matched triple specimens from the lung tumor, normal lung tissue, and peripheral blood of cancer patients. Identical genotypes were observed in normal tissues and blood, while 4 mutations were observed in tumors. The A1 allelic frequency was increased in the adenocarcinoma tissues as compared to normal tissues. Two p53 exon 2 polymorphisms were detected, appearing with equal frequencies among cancer patients and healthy individuals. The p53 intron 2 polymorphic locus is a hot spot for mutations in Hong Kong lung cancer patients.en_HK
dc.languageengen_HK
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_HK
dc.relation.ispartofOncology Reportsen_HK
dc.subjectExon 2en_HK
dc.subjectHong Kongen_HK
dc.subjectIntron 2en_HK
dc.subjectLung carcinomaen_HK
dc.subjectMutationsen_HK
dc.subjectp53en_HK
dc.subjectPolymorphismsen_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - genetics - pathologyen_HK
dc.subject.meshCarcinoma, Small Cell - genetics - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenes, p53en_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntronsen_HK
dc.subject.meshLung - cytology - pathologyen_HK
dc.subject.meshLung Neoplasms - genetics - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMutationen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolymorphism, Single-Stranded Conformationalen_HK
dc.subject.meshReference Valuesen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.titlep53 intron 2 genotypes detected in normal specimens and lung carcinomas in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1021-335X&volume=5&spage=1265&epage=1267&date=1998&atitle=p53+intron+2+genotypes+detected+in+normal+specimens+and+lung+carcinomas+in+Hong+Kongen_HK
dc.identifier.emailWong, MP:mwpik@hkucc.hku.hken_HK
dc.identifier.emailLung, MLI:mlilung@hku.hken_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityLung, MLI=rp00300en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9683848-
dc.identifier.scopuseid_2-s2.0-0031827466en_HK
dc.identifier.hkuros41313en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031827466&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1265en_HK
dc.identifier.epage1267en_HK
dc.identifier.isiWOS:000075336900047-
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridGe, H=55137880800en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridLee, J=27169550700en_HK
dc.identifier.scopusauthoridFu, KH=7202283800en_HK
dc.identifier.scopusauthoridYew, WW=16940459600en_HK
dc.identifier.scopusauthoridLung, MLI=7006411788en_HK

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