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Article: Detection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathy

TitleDetection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathy
Authors
Issue Date2005
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkd
Citation
American Journal Of Kidney Diseases, 2005, v. 45 n. 2, p. 407-410 How to Cite?
AbstractThe authors report a case of unexplained nephropathy 2 months after ingestion of Herba Aristolochia Mollissemae in a patient with long-standing Crohn's disease and recently diagnosed carcinoma of the colon. It presented as a relentlessly progressing hypocellular interstitial nephritis 5 months after cessation of an earlier course of mesalazine. The patient finally had end-stage renal failure 12 months after taking herbs and required hemodialysis. Aristolochic acid (AA) was detected in the herbal sample of Herba Aristolochia Mollissemae by high-performance liquid chromatography-diode array detection and electrospray ionization-tandem mass spectrometry. Specific AA-DNA adducts were detected in the renal biopsy by 32P-postlabelling analysis. Transitional cell carcinoma was diagnosed 5 months after herb ingestion. It was found that the originally prescribed nonnephrotoxic herb had been substituted by AA-containing Herba Aristolochia Mollissemae at the wholesaler level. Although AA-associated nephropathy could not be proved conclusively, the current case contributed to the withdrawal of the AA-related herbs by the local health authority in Hong Kong. Physicians should be on the alert for herbal nephrotoxicity by possible replacement of nontoxic herbs by nephrotoxic herbs. © 2004 by the National Kidney Foundation, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/88723
ISSN
2015 Impact Factor: 6.269
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, SHen_HK
dc.contributor.authorWong, KSen_HK
dc.contributor.authorArlt, VMen_HK
dc.contributor.authorPhillips, DHen_HK
dc.contributor.authorLai, CKen_HK
dc.contributor.authorPoon, WTen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorMo, KLen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorChan, Aen_HK
dc.date.accessioned2010-09-06T09:47:08Z-
dc.date.available2010-09-06T09:47:08Z-
dc.date.issued2005en_HK
dc.identifier.citationAmerican Journal Of Kidney Diseases, 2005, v. 45 n. 2, p. 407-410en_HK
dc.identifier.issn0272-6386en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88723-
dc.description.abstractThe authors report a case of unexplained nephropathy 2 months after ingestion of Herba Aristolochia Mollissemae in a patient with long-standing Crohn's disease and recently diagnosed carcinoma of the colon. It presented as a relentlessly progressing hypocellular interstitial nephritis 5 months after cessation of an earlier course of mesalazine. The patient finally had end-stage renal failure 12 months after taking herbs and required hemodialysis. Aristolochic acid (AA) was detected in the herbal sample of Herba Aristolochia Mollissemae by high-performance liquid chromatography-diode array detection and electrospray ionization-tandem mass spectrometry. Specific AA-DNA adducts were detected in the renal biopsy by 32P-postlabelling analysis. Transitional cell carcinoma was diagnosed 5 months after herb ingestion. It was found that the originally prescribed nonnephrotoxic herb had been substituted by AA-containing Herba Aristolochia Mollissemae at the wholesaler level. Although AA-associated nephropathy could not be proved conclusively, the current case contributed to the withdrawal of the AA-related herbs by the local health authority in Hong Kong. Physicians should be on the alert for herbal nephrotoxicity by possible replacement of nontoxic herbs by nephrotoxic herbs. © 2004 by the National Kidney Foundation, Inc.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkden_HK
dc.relation.ispartofAmerican Journal of Kidney Diseasesen_HK
dc.subject.meshAristolochiaceae - metabolism - poisoningen_HK
dc.subject.meshAristolochic Acids - analysis - poisoningen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKidney - chemistry - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNephritis - chemically induceden_HK
dc.subject.meshPlant Preparations - metabolism - poisoningen_HK
dc.titleDetection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0272-6386&volume=45&issue=2&spage=407&epage=410&date=2005&atitle=Detection+of+Herba+Aristolochia+Mollissemae+in+a+patient+with+unexplained+nephropathyen_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/j.ajkd.2004.09.019en_HK
dc.identifier.pmid15685520-
dc.identifier.scopuseid_2-s2.0-20144364600en_HK
dc.identifier.hkuros97341en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20144364600&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue2en_HK
dc.identifier.spage407en_HK
dc.identifier.epage410en_HK
dc.identifier.isiWOS:000226913000021-
dc.publisher.placeUnited Statesen_HK

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