File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/ajh.2830490107
- Scopus: eid_2-s2.0-0029018992
- PMID: 7741136
- WOS: WOS:A1995QV72200006
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Essential thrombocythemia: A retrospective analysis of 39 cases
Title | Essential thrombocythemia: A retrospective analysis of 39 cases |
---|---|
Authors | |
Keywords | Essential thrombocythemia Treatment |
Issue Date | 1995 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105 |
Citation | American Journal Of Hematology, 1995, v. 49 n. 1, p. 39-42 How to Cite? |
Abstract | Thirty-nine Chinese patients presenting as essential thrombocythemia (ET) were analyzed retrospectively. The median age at presentation was 69 years and the M:F ratio was 1.35:1. At diagnosis, 33 cases (84%) were asymptomatic and the diagnosis was made incidentally, while 3 cases (8%) presented with small vessel, and 2 cases (5%) with large vessel, thrombosis. One patient (3%) presented with minor bleeding. The platelet count ranged from 0.9-34 x 1012/l. Of 12 karyotypes done, 2 cases were abnormal, both showing the Philadelphia (Ph) chromosome. First-line therapy was radiophosphorus (32p) in 3 cases, melphalan in 20 cases, and hydroxyurea in 12 cases; 4 cases did not receive specific therapy. During the follow-up (mean = 4 years), no thrombotic or bleeding episodes were observed. One patient with the Ph chromosome underwent blastic transformation. These results indicate that bleeding and thrombosis occur significantly less in Chinese patients than in Western patients. The Ph chromosome appears to be a bad prognostic indicator. Because of the very low incidence of complications and good prognosis, the authors believe that cytoreductive therapy is best achieved by the use of hydroxyurea instead of alkylating agents or radiophorphours, as the latter agents are potentially leukemogenic. |
Persistent Identifier | http://hdl.handle.net/10722/88709 |
ISSN | 2023 Impact Factor: 10.1 2023 SCImago Journal Rankings: 2.607 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwong, YL | en_HK |
dc.contributor.author | Liang, RHS | en_HK |
dc.contributor.author | Chiu, EKW | en_HK |
dc.contributor.author | Lie, AKW | en_HK |
dc.contributor.author | Chan, LC | en_HK |
dc.contributor.author | Todd, D | en_HK |
dc.contributor.author | Chan, TK | en_HK |
dc.date.accessioned | 2010-09-06T09:46:56Z | - |
dc.date.available | 2010-09-06T09:46:56Z | - |
dc.date.issued | 1995 | en_HK |
dc.identifier.citation | American Journal Of Hematology, 1995, v. 49 n. 1, p. 39-42 | en_HK |
dc.identifier.issn | 0361-8609 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/88709 | - |
dc.description.abstract | Thirty-nine Chinese patients presenting as essential thrombocythemia (ET) were analyzed retrospectively. The median age at presentation was 69 years and the M:F ratio was 1.35:1. At diagnosis, 33 cases (84%) were asymptomatic and the diagnosis was made incidentally, while 3 cases (8%) presented with small vessel, and 2 cases (5%) with large vessel, thrombosis. One patient (3%) presented with minor bleeding. The platelet count ranged from 0.9-34 x 1012/l. Of 12 karyotypes done, 2 cases were abnormal, both showing the Philadelphia (Ph) chromosome. First-line therapy was radiophosphorus (32p) in 3 cases, melphalan in 20 cases, and hydroxyurea in 12 cases; 4 cases did not receive specific therapy. During the follow-up (mean = 4 years), no thrombotic or bleeding episodes were observed. One patient with the Ph chromosome underwent blastic transformation. These results indicate that bleeding and thrombosis occur significantly less in Chinese patients than in Western patients. The Ph chromosome appears to be a bad prognostic indicator. Because of the very low incidence of complications and good prognosis, the authors believe that cytoreductive therapy is best achieved by the use of hydroxyurea instead of alkylating agents or radiophorphours, as the latter agents are potentially leukemogenic. | en_HK |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35105 | en_HK |
dc.relation.ispartof | American Journal of Hematology | en_HK |
dc.rights | Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' | en_HK |
dc.subject | Essential thrombocythemia | en_HK |
dc.subject | Treatment | en_HK |
dc.subject.mesh | Thrombocytosis - blood - genetics - physiopathology | - |
dc.subject.mesh | Splenomegaly - complications | - |
dc.subject.mesh | Hemoglobins - analysis | - |
dc.subject.mesh | Leukocyte count | - |
dc.subject.mesh | Thrombosis - complications | - |
dc.title | Essential thrombocythemia: A retrospective analysis of 39 cases | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0361-8609&volume=49&issue=1&spage=39&epage=42&date=1995&atitle=Essential+thrombocythemia:+a+retrospective+analysis+of+39+cases | en_HK |
dc.identifier.email | Kwong, YL:ylkwong@hku.hk | en_HK |
dc.identifier.email | Liang, RHS:rliang@hku.hk | en_HK |
dc.identifier.email | Chan, LC:chanlc@hkucc.hku.hk | en_HK |
dc.identifier.authority | Kwong, YL=rp00358 | en_HK |
dc.identifier.authority | Liang, RHS=rp00345 | en_HK |
dc.identifier.authority | Chan, LC=rp00373 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/ajh.2830490107 | - |
dc.identifier.pmid | 7741136 | - |
dc.identifier.scopus | eid_2-s2.0-0029018992 | en_HK |
dc.identifier.hkuros | 5981 | en_HK |
dc.identifier.volume | 49 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 39 | en_HK |
dc.identifier.epage | 42 | en_HK |
dc.identifier.isi | WOS:A1995QV72200006 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Kwong, YL=7102818954 | en_HK |
dc.identifier.scopusauthorid | Liang, RHS=26643224900 | en_HK |
dc.identifier.scopusauthorid | Chiu, EKW=24827833600 | en_HK |
dc.identifier.scopusauthorid | Lie, AKW=24284842400 | en_HK |
dc.identifier.scopusauthorid | Chan, LC=7403540707 | en_HK |
dc.identifier.scopusauthorid | Todd, D=7201388182 | en_HK |
dc.identifier.scopusauthorid | Chan, TK=7402687762 | en_HK |
dc.identifier.issnl | 0361-8609 | - |