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Article: Coinfection of multiple strains of Epstein-Barr virus in immunocompetent normal individuals: Reassessment of the viral carrier state

TitleCoinfection of multiple strains of Epstein-Barr virus in immunocompetent normal individuals: Reassessment of the viral carrier state
Authors
Issue Date2000
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 2000, v. 95 n. 7, p. 2443-2445 How to Cite?
AbstractThis study reassesses the occurrence of Epstein-Barr virus (EBV) diversity and coinfection versus dominance of a single viral strain within immunocompetent normal carriers. Polymerase chain reaction analysis of several different polymorphic loci of the EBV genome was performed on collections of peripheral blood mononuclear cells and multiple lymphoid and epithelial tissues of the same individuals. Autopsy specimens from 15 individuals who died of causes unrelated to EBV infection served as normal viral carriers. Unexpectedly, coinfection of multiple distinct strains of EBV of the same type (usually type 1) and less frequently of both types 1 and 2 was found to be very high within individual viral carriers. These data indicate that coinfection with multiple EBV strains is much more prevalent in normal carriers than previously appreciated, which in turn has direct implications on EBV persistence, host-viral interaction and pathogenesis. (C) 2000 by The American Society of Hematology.
Persistent Identifierhttp://hdl.handle.net/10722/88666
ISSN
2015 Impact Factor: 11.841
2015 SCImago Journal Rankings: 6.395
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorWong, KYen_HK
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorTao, Qen_HK
dc.date.accessioned2010-09-06T09:46:22Z-
dc.date.available2010-09-06T09:46:22Z-
dc.date.issued2000en_HK
dc.identifier.citationBlood, 2000, v. 95 n. 7, p. 2443-2445en_HK
dc.identifier.issn0006-4971en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88666-
dc.description.abstractThis study reassesses the occurrence of Epstein-Barr virus (EBV) diversity and coinfection versus dominance of a single viral strain within immunocompetent normal carriers. Polymerase chain reaction analysis of several different polymorphic loci of the EBV genome was performed on collections of peripheral blood mononuclear cells and multiple lymphoid and epithelial tissues of the same individuals. Autopsy specimens from 15 individuals who died of causes unrelated to EBV infection served as normal viral carriers. Unexpectedly, coinfection of multiple distinct strains of EBV of the same type (usually type 1) and less frequently of both types 1 and 2 was found to be very high within individual viral carriers. These data indicate that coinfection with multiple EBV strains is much more prevalent in normal carriers than previously appreciated, which in turn has direct implications on EBV persistence, host-viral interaction and pathogenesis. (C) 2000 by The American Society of Hematology.en_HK
dc.languageengen_HK
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/en_HK
dc.relation.ispartofBlooden_HK
dc.subject.meshCarrier Stateen_HK
dc.subject.meshEpithelium - virologyen_HK
dc.subject.meshEpstein-Barr Virus Infections - immunologyen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHerpesvirus 4, Human - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukocytes, Mononuclear - virologyen_HK
dc.subject.meshLymphoid Tissue - virologyen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_HK
dc.titleCoinfection of multiple strains of Epstein-Barr virus in immunocompetent normal individuals: Reassessment of the viral carrier stateen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-4971&volume=95&issue=7&spage=2443&epage=2445&date=2000&atitle=Coinfection+of+multiple+strains+of+Epstein-Barr+virus+in+immunocompetent+normal+individuals:+reassessment+of+the+viral+carrier+stateen_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10733520-
dc.identifier.scopuseid_2-s2.0-0034177537en_HK
dc.identifier.hkuros48264en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034177537&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue7en_HK
dc.identifier.spage2443en_HK
dc.identifier.epage2445en_HK
dc.identifier.isiWOS:000086130100040-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridWong, KY=7404758500en_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridTao, Q=7102578359en_HK

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