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Article: Segmental small bowel allograft - Ischemic injury and regeneration

TitleSegmental small bowel allograft - Ischemic injury and regeneration
Authors
Issue Date1998
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
Citation
Journal Of Pediatric Surgery, 1998, v. 33 n. 11, p. 1703-1706 How to Cite?
AbstractPurpose: Small bowel transplantation (SBT) is the ultimate treatment for intestinal failure. It remains unclear as to which intestinal segment is more suitable for use in segmental SBT. The current study aims to assess the susceptibility of various parts of small intestine to ischemia and reperfusion injury and their capacity for regeneration. Methods: Thirty-two segments of pig jejunum and ileum were isolated with intact vascular pedicles that were clamped for periods varying from 1/2 to 8 hours. Biopsy specimens were taken immediately before clamp release and 20 minutes afterwards. All segments were anastomosed together before abdominal closure. Laparotomy was performed 24 hours later, and biopsy specimens were taken at all segments. All specimens were examined histologically by a pathologist. Results: Evidence of injury was detected after 1.5 hours of ischemia at jejunum, but only after 5 hours at ileum. More severe injury was noted at the initial period on reperfusion, but there was no further deterioration at the later period. Complete reepithelialization occurred after 24 hours even where there had been total villous sloughing at reperfusion, but regeneration was impossible when the crypts had been damaged completely. Conclusions: ileum, because it is more resistant to ischemia and reperfusion injury, may be preferred for segmental SBT. Regeneration of the bowel epithelium is fast, provided that the crypts are not damaged completely.
Persistent Identifierhttp://hdl.handle.net/10722/88649
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.802
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KLen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-06T09:46:09Z-
dc.date.available2010-09-06T09:46:09Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Pediatric Surgery, 1998, v. 33 n. 11, p. 1703-1706en_HK
dc.identifier.issn0022-3468en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88649-
dc.description.abstractPurpose: Small bowel transplantation (SBT) is the ultimate treatment for intestinal failure. It remains unclear as to which intestinal segment is more suitable for use in segmental SBT. The current study aims to assess the susceptibility of various parts of small intestine to ischemia and reperfusion injury and their capacity for regeneration. Methods: Thirty-two segments of pig jejunum and ileum were isolated with intact vascular pedicles that were clamped for periods varying from 1/2 to 8 hours. Biopsy specimens were taken immediately before clamp release and 20 minutes afterwards. All segments were anastomosed together before abdominal closure. Laparotomy was performed 24 hours later, and biopsy specimens were taken at all segments. All specimens were examined histologically by a pathologist. Results: Evidence of injury was detected after 1.5 hours of ischemia at jejunum, but only after 5 hours at ileum. More severe injury was noted at the initial period on reperfusion, but there was no further deterioration at the later period. Complete reepithelialization occurred after 24 hours even where there had been total villous sloughing at reperfusion, but regeneration was impossible when the crypts had been damaged completely. Conclusions: ileum, because it is more resistant to ischemia and reperfusion injury, may be preferred for segmental SBT. Regeneration of the bowel epithelium is fast, provided that the crypts are not damaged completely.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurgen_HK
dc.relation.ispartofJournal of Pediatric Surgeryen_HK
dc.subject.meshAnastomosis, Surgicalen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBiopsy, Needleen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshIleum - blood supply - pathology - transplantationen_HK
dc.subject.meshIntestinal Mucosa - pathologyen_HK
dc.subject.meshIntestine, Small - blood supply - pathology - transplantationen_HK
dc.subject.meshIschemia - pathologyen_HK
dc.subject.meshJejunum - blood supply - pathology - transplantationen_HK
dc.subject.meshRegeneration - physiologyen_HK
dc.subject.meshReperfusion Injury - pathologyen_HK
dc.subject.meshSwineen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.titleSegmental small bowel allograft - Ischemic injury and regenerationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3468&volume=33&spage=1703&epage=1706&date=1998&atitle=Segmental+small+bowel+allograft+-+ischemic+injury+and+regenerationen_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailTam, PKH:paultam@hkucc.hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9856900-
dc.identifier.scopuseid_2-s2.0-0031795154en_HK
dc.identifier.hkuros39813en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031795154&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1703en_HK
dc.identifier.epage1706en_HK
dc.identifier.isiWOS:000077131500029-
dc.publisher.placeUnited Statesen_HK

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