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Article: Management of extensive cervical nodal metastasis in nasopharyngeal carcinoma after radiotherapy: A clinicopathological study
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TitleManagement of extensive cervical nodal metastasis in nasopharyngeal carcinoma after radiotherapy: A clinicopathological study
 
AuthorsWei, WI1
Ho, WK1
Cheng, ACK1
Wu, X1
Li, GKH1
Nicholls, J1
Yuen, PW1
Sham, JST1
 
Issue Date2001
 
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.com
 
CitationArchives Of Otolaryngology - Head And Neck Surgery, 2001, v. 127 n. 12, p. 1457-1462 [How to Cite?]
 
AbstractObjectives: To evaluate the efficacy of afterloading brachytherapy following radical neck dissection (RND) in the management of extensive cervical lymph node disease in nasopharyngeal carcinoma after radiotherapy; and to examine prospectively prognostic factors and the pathologic behavior of neck disease. Patients: Twenty-seven patients with nasopharyngeal carcinoma who had extensive cervical lymph node metastasis following external radiotherapy were treated with RND. Thirteen of them also underwent afterloading brachytherapy with iridium wire (Ir 192). The RND specimens of the 27 patients were also examined with step serial whole-specimen sectioning. Results: All patients survived and their wounds healed primarily. Pathologic examination revealed 183 tumorbearing lymph nodes that contained tumors in the neck: level I, 4% (8/183); level II, 53% (96/183); level III, 34% (62/183); level IV, 5% (9/183); and level V, 4% (8/183). Extracapsular tumor extension was seen in 84% of patients. Multivariate analysis identified the number of tumor-bearing lymph nodes detected in the specimens to be the only significant factor that affected control of disease. Although the neck disease in the group of patients who had afterloading brachytherapy was more extensive, the 3-year actuarial tumor control for the groups with and without brachytherapy were 60% and 61%, respectively. Conclusions: Recurrent cervical lymph nodes after radiotherapy in nasopharyngeal carcinoma are extensive and RND is mandatory for a successful salvage. When the nodal metastasis infiltrate or adhere to surrounding tissue, afterloading brachytherapy with iridium wire can provide satisfactory local tumor control.
 
ISSN0886-4470
2013 Impact Factor: 1.748
 
ISI Accession Number IDWOS:000172657600006
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWei, WI
 
dc.contributor.authorHo, WK
 
dc.contributor.authorCheng, ACK
 
dc.contributor.authorWu, X
 
dc.contributor.authorLi, GKH
 
dc.contributor.authorNicholls, J
 
dc.contributor.authorYuen, PW
 
dc.contributor.authorSham, JST
 
dc.date.accessioned2010-09-06T09:45:51Z
 
dc.date.available2010-09-06T09:45:51Z
 
dc.date.issued2001
 
dc.description.abstractObjectives: To evaluate the efficacy of afterloading brachytherapy following radical neck dissection (RND) in the management of extensive cervical lymph node disease in nasopharyngeal carcinoma after radiotherapy; and to examine prospectively prognostic factors and the pathologic behavior of neck disease. Patients: Twenty-seven patients with nasopharyngeal carcinoma who had extensive cervical lymph node metastasis following external radiotherapy were treated with RND. Thirteen of them also underwent afterloading brachytherapy with iridium wire (Ir 192). The RND specimens of the 27 patients were also examined with step serial whole-specimen sectioning. Results: All patients survived and their wounds healed primarily. Pathologic examination revealed 183 tumorbearing lymph nodes that contained tumors in the neck: level I, 4% (8/183); level II, 53% (96/183); level III, 34% (62/183); level IV, 5% (9/183); and level V, 4% (8/183). Extracapsular tumor extension was seen in 84% of patients. Multivariate analysis identified the number of tumor-bearing lymph nodes detected in the specimens to be the only significant factor that affected control of disease. Although the neck disease in the group of patients who had afterloading brachytherapy was more extensive, the 3-year actuarial tumor control for the groups with and without brachytherapy were 60% and 61%, respectively. Conclusions: Recurrent cervical lymph nodes after radiotherapy in nasopharyngeal carcinoma are extensive and RND is mandatory for a successful salvage. When the nodal metastasis infiltrate or adhere to surrounding tissue, afterloading brachytherapy with iridium wire can provide satisfactory local tumor control.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationArchives Of Otolaryngology - Head And Neck Surgery, 2001, v. 127 n. 12, p. 1457-1462 [How to Cite?]
 
dc.identifier.epage1462
 
dc.identifier.hkuros66025
 
dc.identifier.isiWOS:000172657600006
 
dc.identifier.issn0886-4470
2013 Impact Factor: 1.748
 
dc.identifier.issue12
 
dc.identifier.openurl
 
dc.identifier.pmid11735814
 
dc.identifier.scopuseid_2-s2.0-0035215882
 
dc.identifier.spage1457
 
dc.identifier.urihttp://hdl.handle.net/10722/88626
 
dc.identifier.volume127
 
dc.languageeng
 
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archoto.com
 
dc.publisher.placeUnited States
 
dc.relation.ispartofArchives of Otolaryngology - Head and Neck Surgery
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshBrachytherapy
 
dc.subject.meshCarcinoma - mortality - pathology - radiotherapy - therapy
 
dc.subject.meshCombined Modality Therapy
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshIridium Radioisotopes - therapeutic use
 
dc.subject.meshLymphatic Metastasis
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNasopharyngeal Neoplasms - mortality - pathology - radiotherapy - therapy
 
dc.subject.meshNeck
 
dc.subject.meshNeck Dissection
 
dc.subject.meshPrognosis
 
dc.subject.meshProspective Studies
 
dc.subject.meshSurvival Rate
 
dc.titleManagement of extensive cervical nodal metastasis in nasopharyngeal carcinoma after radiotherapy: A clinicopathological study
 
dc.typeArticle
 
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<contributor.author>Li, GKH</contributor.author>
<contributor.author>Nicholls, J</contributor.author>
<contributor.author>Yuen, PW</contributor.author>
<contributor.author>Sham, JST</contributor.author>
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Author Affiliations
  1. The University of Hong Kong