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Article: Differences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: Implications on cellular origin

TitleDifferences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: Implications on cellular origin
Authors
Keywordsgene rearrangement
gene transcription
nasal lymphomas
natural killer cells
T-cell receptor
Issue Date1996
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 1996, v. 27 n. 7, p. 701-707 How to Cite?
AbstractAlthough nasal lymphomas showing midfacial destructive lesions had been classified as T-cell lymphomas, their exact cellular origin is still unclear. Although they usually express a restricted number of T-cell-related antigens, namely, CD2, CD43, and CD45RO, other pan-T or subset-T-lineage antigens, such as CD3 (membrane), CD5, CD4, CD8, and CD7, are frequently absent. Conversely, they often express a natural killer (NK) cell-associated antigen, CD56, but lack other mature NK markers. To study their cellular origin further, the authors analyzed T-cell receptor (TCR) gene transcription in three cases of nasal lymphomas and correlated the findings with the phenotype and gene rearrangement data. Two cases of nasal lymphomas with CD2+CD3(Leu4)-CD19- CD56+ phenotype were shown to express truncated 1.0-kb T(β) and multiple unrearranged T(δ) transcripts with germline TCR β, γ, δ, and immunoglobulin heavy-chain joining region (J(H)) genes, consistent with NK cell lineage. In contrast, one case of nasal lymphoma with CD2tCD3(Leu4)+CD8+CD19-CD56+ phenotype expressed full-length T(α), T(β), and T(γ) transcriptswith rearranged TCR β, γ, and deleted TCR δ genes, indicating T-cell lineage. These results support the view that nasal lymphomas can be separated into NK-cell and T-cell neoplasms, based on differences in genotypic characteristics. The possibility of these tumors being derived from a putative common precursor cell merits further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/88612
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChiang, AKSen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorLau, PWFen_HK
dc.contributor.authorHo, FCSen_HK
dc.date.accessioned2010-09-06T09:45:40Z-
dc.date.available2010-09-06T09:45:40Z-
dc.date.issued1996en_HK
dc.identifier.citationHuman Pathology, 1996, v. 27 n. 7, p. 701-707en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88612-
dc.description.abstractAlthough nasal lymphomas showing midfacial destructive lesions had been classified as T-cell lymphomas, their exact cellular origin is still unclear. Although they usually express a restricted number of T-cell-related antigens, namely, CD2, CD43, and CD45RO, other pan-T or subset-T-lineage antigens, such as CD3 (membrane), CD5, CD4, CD8, and CD7, are frequently absent. Conversely, they often express a natural killer (NK) cell-associated antigen, CD56, but lack other mature NK markers. To study their cellular origin further, the authors analyzed T-cell receptor (TCR) gene transcription in three cases of nasal lymphomas and correlated the findings with the phenotype and gene rearrangement data. Two cases of nasal lymphomas with CD2+CD3(Leu4)-CD19- CD56+ phenotype were shown to express truncated 1.0-kb T(β) and multiple unrearranged T(δ) transcripts with germline TCR β, γ, δ, and immunoglobulin heavy-chain joining region (J(H)) genes, consistent with NK cell lineage. In contrast, one case of nasal lymphoma with CD2tCD3(Leu4)+CD8+CD19-CD56+ phenotype expressed full-length T(α), T(β), and T(γ) transcriptswith rearranged TCR β, γ, and deleted TCR δ genes, indicating T-cell lineage. These results support the view that nasal lymphomas can be separated into NK-cell and T-cell neoplasms, based on differences in genotypic characteristics. The possibility of these tumors being derived from a putative common precursor cell merits further investigation.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subjectgene rearrangementen_HK
dc.subjectgene transcriptionen_HK
dc.subjectnasal lymphomasen_HK
dc.subjectnatural killer cellsen_HK
dc.subjectT-cell receptoren_HK
dc.subject.meshGene Rearrangement, T-Lymphocyteen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKiller Cells, Natural - immunology - pathologyen_HK
dc.subject.meshLymphoma - genetics - immunology - pathologyen_HK
dc.subject.meshLymphoma, T-Cell - genetics - immunology - pathologyen_HK
dc.subject.meshNose Neoplasms - genetics - immunology - pathologyen_HK
dc.subject.meshPhenotypeen_HK
dc.subject.meshReceptors, Antigen, T-Cell - geneticsen_HK
dc.subject.meshTranscription, Geneticen_HK
dc.titleDifferences in T-cell-receptor gene rearrangement and transcription in nasal lymphomas of natural killer and T-cell types: Implications on cellular originen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=27&issue=7&spage=701&epage=707&date=1996&atitle=Differences+in+T-Cell-Receptor+Gene+Rearrangement+and+Transcription+in+Nasal+Lymphomas+of+Natural+Killer+and+T-Cell+Types:+Implications+On+Cellular+Originen_HK
dc.identifier.emailChiang, AKS:chiangak@hkucc.hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authorityChiang, AKS=rp00403en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0046-8177(96)90401-3en_HK
dc.identifier.pmid8698315en_HK
dc.identifier.scopuseid_2-s2.0-0030013623en_HK
dc.identifier.hkuros56484en_HK
dc.identifier.hkuros26056-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030013623&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue7en_HK
dc.identifier.spage701en_HK
dc.identifier.epage707en_HK
dc.identifier.isiWOS:A1996UW74400014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChiang, AKS=7101623534en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridLau, PWF=7102543475en_HK
dc.identifier.scopusauthoridHo, FCS=7103408147en_HK

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