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Article: Epstein-Barr virus is localized in the tumour cells of nasal lymphomas of NK, T or B cell type

TitleEpstein-Barr virus is localized in the tumour cells of nasal lymphomas of NK, T or B cell type
Authors
Issue Date1995
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 1995, v. 60 n. 3, p. 315-320 How to Cite?
AbstractSeven cases of nasal lymphoma were studied to identify the lineage of Epstein-Barr virus (EBV)+ cells using dual-labelling methods. Five cases were phenotypically and genotypically of natural killer cell (NK) type with germ-line configuration of T-cell receptor (TcR) β-chain gene and immunoglobulin heavy-chain joining region (IgJ(H)) gene, with one case each of T- and B-cell type showing rearranged TcRβ or IgJ(H) and λ-light chain genes respectively. EBV genome was clonal in all these cases except in the B-cell case where its clonality was undeterminable. Using in situ hybridization (ISH) for EBV-encoded small nuclear RNA 1 and 2 (EBER), signal was detected in 45% to 88% of nucleated cells in the tumours. Immunostaining for EBV latent membrane protein-1 (LMP) also revealed numerous LMP+ cells in 3/5 NK-type cases and the T- and B-cell cases. Using ISH for EBER combined with immunostaining for CD markers and double immunohistochemistry for LMP and CD markers, the predominant lineage of the EBV+ cells was identified as: CD2+CD3-CD19-CD20- CD45R0(±)CD56+CD68- in the NK-type cases, CD2+CD3(±)CD19-CD20- CD45R0(±)CD56-CD68- in the T-cell case and CD20+CD45R0-CD68- in the B-cell case, in agreement with the genotype and phenotype of each tumour. These results show that, in EBV+ nasal lymphomas of NK, T- or B-cell lineage, EBV was consistently associated with the tumour-cell population and support the view that EBV serves a promoting role in the pathogenesis of different types of EBV+ nasal lymphoma.
Persistent Identifierhttp://hdl.handle.net/10722/88606
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTao, Qen_HK
dc.contributor.authorHo, FCSen_HK
dc.contributor.authorLoke, SLen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.date.accessioned2010-09-06T09:45:35Z-
dc.date.available2010-09-06T09:45:35Z-
dc.date.issued1995en_HK
dc.identifier.citationInternational Journal Of Cancer, 1995, v. 60 n. 3, p. 315-320en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88606-
dc.description.abstractSeven cases of nasal lymphoma were studied to identify the lineage of Epstein-Barr virus (EBV)+ cells using dual-labelling methods. Five cases were phenotypically and genotypically of natural killer cell (NK) type with germ-line configuration of T-cell receptor (TcR) β-chain gene and immunoglobulin heavy-chain joining region (IgJ(H)) gene, with one case each of T- and B-cell type showing rearranged TcRβ or IgJ(H) and λ-light chain genes respectively. EBV genome was clonal in all these cases except in the B-cell case where its clonality was undeterminable. Using in situ hybridization (ISH) for EBV-encoded small nuclear RNA 1 and 2 (EBER), signal was detected in 45% to 88% of nucleated cells in the tumours. Immunostaining for EBV latent membrane protein-1 (LMP) also revealed numerous LMP+ cells in 3/5 NK-type cases and the T- and B-cell cases. Using ISH for EBER combined with immunostaining for CD markers and double immunohistochemistry for LMP and CD markers, the predominant lineage of the EBV+ cells was identified as: CD2+CD3-CD19-CD20- CD45R0(±)CD56+CD68- in the NK-type cases, CD2+CD3(±)CD19-CD20- CD45R0(±)CD56-CD68- in the T-cell case and CD20+CD45R0-CD68- in the B-cell case, in agreement with the genotype and phenotype of each tumour. These results show that, in EBV+ nasal lymphomas of NK, T- or B-cell lineage, EBV was consistently associated with the tumour-cell population and support the view that EBV serves a promoting role in the pathogenesis of different types of EBV+ nasal lymphoma.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshClone Cellsen_HK
dc.subject.meshDNA, Viral - analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Rearrangement, B-Lymphocyteen_HK
dc.subject.meshGene Rearrangement, T-Lymphocyteen_HK
dc.subject.meshHerpesvirus 4, Human - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunophenotypingen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshKiller Cells, Natural - pathologyen_HK
dc.subject.meshLymphoma - microbiology - pathologyen_HK
dc.subject.meshLymphoma, B-Cell - microbiologyen_HK
dc.subject.meshLymphoma, T-Cell - microbiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNose Neoplasms - microbiology - pathologyen_HK
dc.subject.meshOncogene Proteins, Viral - metabolismen_HK
dc.subject.meshRNA, Small Nuclear - geneticsen_HK
dc.subject.meshRNA, Viral - geneticsen_HK
dc.subject.meshViral Matrix Proteins - metabolismen_HK
dc.titleEpstein-Barr virus is localized in the tumour cells of nasal lymphomas of NK, T or B cell typeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7136&volume=60&spage=315&epage=320&date=1995&atitle=Epstein-Barr+virus+is+localized+in+the+tumour+cells+of+nasal+lymphomas+of+NK,+T+or+B+cell+typeen_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7829236en_HK
dc.identifier.scopuseid_2-s2.0-0028842219en_HK
dc.identifier.hkuros5252en_HK
dc.identifier.volume60en_HK
dc.identifier.issue3en_HK
dc.identifier.spage315en_HK
dc.identifier.epage320en_HK
dc.identifier.isiWOS:A1995QG23500005-
dc.publisher.placeUnited Statesen_HK

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