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Article: Focal segmental glomerulosclerosis after membranous glomerulonephritis in remission: temporal diversity of glomerulopathy after bone marrow transplantation

TitleFocal segmental glomerulosclerosis after membranous glomerulonephritis in remission: temporal diversity of glomerulopathy after bone marrow transplantation
Authors
Issue Date2006
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 2006, v. 37 n. 12, p. 1607-1610 How to Cite?
AbstractHeavy proteinuria after bone marrow transplantation (BMT) is rare. Pathology shows membranous glomerulonephritis (MGN) in most cases. After BMT, focal segmental glomerulosclerosis (FSGS) after resolution of MGN has not been reported. We describe a 13-year-old boy who had matched unrelated donor allogeneic BMT for relapsed acute lymphoblastic leukemia, complicated by chronic graft-versus-host disease. Nephrotic syndrome developed 1 year after BMT and renal biopsy revealed MGN. Immunosuppressive therapy achieved good clinical remission, and treatment was stopped after 15 months. He developed significant proteinuria 55 months later. The second renal biopsy showed FSGS without changes of MGN. This distinctive disease evolution gives inspiring implications. Complete morphological resolution of graft-versus-host disease-associated MGN, achieved in our case, has not been previously documented. Recurrent significant proteinuria after BMT is not necessarily due to previous renal lesion, and a repeat renal biopsy is indicated. The pathogenesis of MGN and FSGS are different, and different mechanisms of glomerular injury can interplay in a single patient after BMT. This case helps to expand our knowledge of the temporal morphological spectrum of renal lesions associated with BMT. © 2006.
Persistent Identifierhttp://hdl.handle.net/10722/88546
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShuengWai Chan, Gen_HK
dc.contributor.authorChim, Sen_HK
dc.contributor.authorFan, YSen_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2010-09-06T09:44:47Z-
dc.date.available2010-09-06T09:44:47Z-
dc.date.issued2006en_HK
dc.identifier.citationHuman Pathology, 2006, v. 37 n. 12, p. 1607-1610en_HK
dc.identifier.issn0046-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88546-
dc.description.abstractHeavy proteinuria after bone marrow transplantation (BMT) is rare. Pathology shows membranous glomerulonephritis (MGN) in most cases. After BMT, focal segmental glomerulosclerosis (FSGS) after resolution of MGN has not been reported. We describe a 13-year-old boy who had matched unrelated donor allogeneic BMT for relapsed acute lymphoblastic leukemia, complicated by chronic graft-versus-host disease. Nephrotic syndrome developed 1 year after BMT and renal biopsy revealed MGN. Immunosuppressive therapy achieved good clinical remission, and treatment was stopped after 15 months. He developed significant proteinuria 55 months later. The second renal biopsy showed FSGS without changes of MGN. This distinctive disease evolution gives inspiring implications. Complete morphological resolution of graft-versus-host disease-associated MGN, achieved in our case, has not been previously documented. Recurrent significant proteinuria after BMT is not necessarily due to previous renal lesion, and a repeat renal biopsy is indicated. The pathogenesis of MGN and FSGS are different, and different mechanisms of glomerular injury can interplay in a single patient after BMT. This case helps to expand our knowledge of the temporal morphological spectrum of renal lesions associated with BMT. © 2006.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_HK
dc.relation.ispartofHuman Pathologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshBone Marrow Transplantation - adverse effectsen_HK
dc.subject.meshGlomerulonephritis, Membranous - therapyen_HK
dc.subject.meshGlomerulosclerosis, Focal Segmental - etiology - pathologyen_HK
dc.subject.meshGraft vs Host Disease - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKidney - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshProteinuria - etiologyen_HK
dc.titleFocal segmental glomerulosclerosis after membranous glomerulonephritis in remission: temporal diversity of glomerulopathy after bone marrow transplantationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0046-8177&volume=37&issue=12&spage=1607&epage=10&date=2006&atitle=Focal+segmental+glomerulosclerosis+after+membranous+glomerulonephritis+in+remission:+temporal+diversity+of+glomerulopathy+after+bone+marrow+transplantationen_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.humpath.2006.07.011en_HK
dc.identifier.pmid17020780-
dc.identifier.scopuseid_2-s2.0-33751218933en_HK
dc.identifier.hkuros125357en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33751218933&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1607en_HK
dc.identifier.epage1610en_HK
dc.identifier.isiWOS:000242811900013-
dc.publisher.placeUnited Statesen_HK

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