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Article: Clonality of lymphomas at multiple sites in SJL mice

TitleClonality of lymphomas at multiple sites in SJL mice
Authors
Issue Date1998
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/labinvest/
Citation
Laboratory Investigation, 1998, v. 78 n. 2, p. 205-212 How to Cite?
AbstractSJL mice are an inbred strain of mice with a high incidence of spontaneous lymphomas of B-cell type often involving multiple abdominal organs, and are therefore a useful model for studying the clonal relationship among lymphomas at multiple sites. Thirteen SJL mice with wail-developed tumors were killed at a median age of 56 weeks. Autopsy samples were taken from various enlarged lymphoid organs, and the histologic appearance of lymphomas was recorded. Using rearrangements of immunoglobulin genes (heavy and κ-light chain genes) and integration patterns of murine leukemia virus as clonal markers, 7 of the 13 informative mice showed complete clonal identity among the different sites selected from each mouse; 5 of 13 mice demonstrated at least one shared clonal band with one or more markers being different among the different sites. The histologic appearance of the lymphomas from the various sites was found to be heterogeneous, even when there was clonal identity. These findings suggest that SJL lymphomas in multiple sites within one mouse are usually derived from a single clone but may show development of subclones within a major clonal population, thus supporting the notion that clonal evolution is a common event in the course of development of lymphoid neoplasia.
Persistent Identifierhttp://hdl.handle.net/10722/88523
ISSN
2015 Impact Factor: 4.202
2015 SCImago Journal Rankings: 2.133
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, JCOen_HK
dc.contributor.authorHo, FCSen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.date.accessioned2010-09-06T09:44:29Z-
dc.date.available2010-09-06T09:44:29Z-
dc.date.issued1998en_HK
dc.identifier.citationLaboratory Investigation, 1998, v. 78 n. 2, p. 205-212en_HK
dc.identifier.issn0023-6837en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88523-
dc.description.abstractSJL mice are an inbred strain of mice with a high incidence of spontaneous lymphomas of B-cell type often involving multiple abdominal organs, and are therefore a useful model for studying the clonal relationship among lymphomas at multiple sites. Thirteen SJL mice with wail-developed tumors were killed at a median age of 56 weeks. Autopsy samples were taken from various enlarged lymphoid organs, and the histologic appearance of lymphomas was recorded. Using rearrangements of immunoglobulin genes (heavy and κ-light chain genes) and integration patterns of murine leukemia virus as clonal markers, 7 of the 13 informative mice showed complete clonal identity among the different sites selected from each mouse; 5 of 13 mice demonstrated at least one shared clonal band with one or more markers being different among the different sites. The histologic appearance of the lymphomas from the various sites was found to be heterogeneous, even when there was clonal identity. These findings suggest that SJL lymphomas in multiple sites within one mouse are usually derived from a single clone but may show development of subclones within a major clonal population, thus supporting the notion that clonal evolution is a common event in the course of development of lymphoid neoplasia.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/labinvest/en_HK
dc.relation.ispartofLaboratory Investigationen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshClone Cells - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Rearrangementen_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshImmunoglobulins - geneticsen_HK
dc.subject.meshLeukemia Virus, Murine - geneticsen_HK
dc.subject.meshLymphoma - genetics - pathology - virologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred Strainsen_HK
dc.titleClonality of lymphomas at multiple sites in SJL miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0023-6837&volume=78 &issue=2&spage=205 &epage= 212&date=1998&atitle=Clonality+of+Lymphomas+at+Multiple+Sites+in+SJL+Miceen_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9484718-
dc.identifier.scopuseid_2-s2.0-0031915807en_HK
dc.identifier.hkuros38476en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031915807&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue2en_HK
dc.identifier.spage205en_HK
dc.identifier.epage212en_HK
dc.identifier.isiWOS:000072076400008-
dc.publisher.placeUnited Kingdomen_HK

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