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Article: Androgen induces differentiation of a human papillomavirus 16 E6/E7 immortalized prostate epithelial cell line

TitleAndrogen induces differentiation of a human papillomavirus 16 E6/E7 immortalized prostate epithelial cell line
Authors
Issue Date2001
PublisherSociety for Endocrinology. The Journal's web site is located at http://joe.endocrinology-journals.org
Citation
Journal Of Endocrinology, 2001, v. 170 n. 1, p. 287-296 How to Cite?
AbstractAndrogen signaling is crucial for the growth and development, as well as for tumorigenesis of the prostate. However, many of the prostate epithelial cell lines developed previously, either normal or tumorigenic, do not express androgen receptor (AR) or respond to androgen. In order to advance our understanding on how androgen signaling regulates the growth and the differentiation status, and affects tumorigenicity of the epithelial cell, we performed experiments on HPr-1, a prostate cell line recently immortalized from normal human prostate epithelial cells. In the present study, AR was stably transfected into HPr-1 cells by replication-defective retrovirus. Treatment of HPr-1AR cells with androgen resulted in cell differentiation and growth retardation accompanied with up-regulation of cytokeratins K8 and K18, prostate specific antigen, p21 and p27, and down-regulation of c-myc, bcl-2 and telomerase activity. Our results suggest that androgen promotes the process of differentiation in a human papillomavirus 16 E6/E7 immortalized prostate epithelial cell line which may reflect the normal effects of androgen on prostate cells.
Persistent Identifierhttp://hdl.handle.net/10722/88438
ISSN
2015 Impact Factor: 4.498
2015 SCImago Journal Rankings: 1.910
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLing, MTen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorChoo, CKen_HK
dc.date.accessioned2010-09-06T09:43:22Z-
dc.date.available2010-09-06T09:43:22Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Endocrinology, 2001, v. 170 n. 1, p. 287-296en_HK
dc.identifier.issn0022-0795en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88438-
dc.description.abstractAndrogen signaling is crucial for the growth and development, as well as for tumorigenesis of the prostate. However, many of the prostate epithelial cell lines developed previously, either normal or tumorigenic, do not express androgen receptor (AR) or respond to androgen. In order to advance our understanding on how androgen signaling regulates the growth and the differentiation status, and affects tumorigenicity of the epithelial cell, we performed experiments on HPr-1, a prostate cell line recently immortalized from normal human prostate epithelial cells. In the present study, AR was stably transfected into HPr-1 cells by replication-defective retrovirus. Treatment of HPr-1AR cells with androgen resulted in cell differentiation and growth retardation accompanied with up-regulation of cytokeratins K8 and K18, prostate specific antigen, p21 and p27, and down-regulation of c-myc, bcl-2 and telomerase activity. Our results suggest that androgen promotes the process of differentiation in a human papillomavirus 16 E6/E7 immortalized prostate epithelial cell line which may reflect the normal effects of androgen on prostate cells.en_HK
dc.languageengen_HK
dc.publisherSociety for Endocrinology. The Journal's web site is located at http://joe.endocrinology-journals.orgen_HK
dc.relation.ispartofJournal of Endocrinologyen_HK
dc.rightsJournal of Endocrinology. Copyright © Society for Endocrinology.en_HK
dc.subject.meshAndrogens - pharmacologyen_HK
dc.subject.meshCell Differentiation - drug effectsen_HK
dc.subject.meshCell Division - drug effectsen_HK
dc.subject.meshCell Line, Transformed - drug effectsen_HK
dc.subject.meshCyclin-Dependent Kinase Inhibitor p21en_HK
dc.subject.meshCyclins - metabolismen_HK
dc.subject.meshEpithelial Cells - drug effects - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKeratins - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrofilament Proteins - metabolismen_HK
dc.subject.meshMuscle Proteinsen_HK
dc.subject.meshPapillomaviridaeen_HK
dc.subject.meshProstate - cytology - drug effectsen_HK
dc.subject.meshProstate-Specific Antigen - metabolismen_HK
dc.subject.meshProstatic Neoplasms - therapyen_HK
dc.subject.meshProto-Oncogene Proteins - metabolismen_HK
dc.subject.meshProto-Oncogene Proteins c-bcl-2 - metabolismen_HK
dc.subject.meshProto-Oncogene Proteins c-myc - metabolismen_HK
dc.subject.meshReceptors, Androgen - geneticsen_HK
dc.subject.meshStimulation, Chemicalen_HK
dc.subject.meshTelomerase - metabolismen_HK
dc.subject.meshTransfection - methodsen_HK
dc.subject.meshbcl-2-Associated X Proteinen_HK
dc.titleAndrogen induces differentiation of a human papillomavirus 16 E6/E7 immortalized prostate epithelial cell lineen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0795&volume=170&spage=287&epage=296&date=2001&atitle=Androgen+induces+differentiation+of+a+human+papillomavirus+16+E6/E7+immortalized+prostate+epithelial+cell+lineen_HK
dc.identifier.emailLing, MT:patling@hkucc.hku.hken_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.authorityLing, MT=rp00449en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1677/joe.0.1700287en_HK
dc.identifier.pmid11431162-
dc.identifier.scopuseid_2-s2.0-0034913316en_HK
dc.identifier.hkuros63386en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034913316&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume170en_HK
dc.identifier.issue1en_HK
dc.identifier.spage287en_HK
dc.identifier.epage296en_HK
dc.identifier.isiWOS:000169820600032-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLing, MT=7102229780en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridChoo, CK=35866260100en_HK

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