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Conference Paper: Functional investigation of tumor suppressive role of chromosome 9 in esophageal squamous cell carcinoma

TitleFunctional investigation of tumor suppressive role of chromosome 9 in esophageal squamous cell carcinoma
Authors
Issue Date2004
PublisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/
Citation
Journal of Clinical Oncology, 2004, v. 22 n. 14S, p. 852S Abstract no. 9571 How to Cite?
AbstractBackground: Esophageal carcinoma (EC) is a very deadly disease, but its molecular basis for tumorigenesis is still largely unknown. The microcell chromosome transfer technique is useful to functionally validate the presence of tumor suppressor genes (TSGs). Early studies indicate there might be important TSGs for EC on chromosome 9. Our study found the LOH frequency of chromosome 9 was very high and three commonly deleted regions were observed at 9p23 –22, 9q13 –22.3, and 9q34 , which suggest the probable locations of TSGs on chromosome 9 involved in esophageal tumorigenesis. Methods: Transfer of chromosome 9 into the highly tumorigenic EC cell line, SLMT-1S1, was accomplished by the method of microcell-mediated chromosome transfer (MMCT). Hybrid cells and their corresponding tumor segregants were studied for the ability to form tumors in a nude mouse model and 33 microsatellite markers were used to detect critical regions associated with their tumor suppression. Results: Comparison of the tumor suppressive hybrid cell lines and their paired tumor segregants, showed some critical regions were non-randomly eliminated, including the 9q22 .1 and 9q22 .3 regions. Conclusions: These results indicate several chromosome 9q regions may contain important TSGs for EC. These functional complementation experiments are expected to map the putative TSGs of EC.
Persistent Identifierhttp://hdl.handle.net/10722/88435
ISSN
2015 Impact Factor: 20.982
2015 SCImago Journal Rankings: 9.204

 

DC FieldValueLanguage
dc.contributor.authorYang, LCen_HK
dc.contributor.authorTang, JCOen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorStanbridge, EJen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2010-09-06T09:43:20Z-
dc.date.available2010-09-06T09:43:20Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal of Clinical Oncology, 2004, v. 22 n. 14S, p. 852S Abstract no. 9571en_HK
dc.identifier.issn0732-183Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/88435-
dc.description.abstractBackground: Esophageal carcinoma (EC) is a very deadly disease, but its molecular basis for tumorigenesis is still largely unknown. The microcell chromosome transfer technique is useful to functionally validate the presence of tumor suppressor genes (TSGs). Early studies indicate there might be important TSGs for EC on chromosome 9. Our study found the LOH frequency of chromosome 9 was very high and three commonly deleted regions were observed at 9p23 –22, 9q13 –22.3, and 9q34 , which suggest the probable locations of TSGs on chromosome 9 involved in esophageal tumorigenesis. Methods: Transfer of chromosome 9 into the highly tumorigenic EC cell line, SLMT-1S1, was accomplished by the method of microcell-mediated chromosome transfer (MMCT). Hybrid cells and their corresponding tumor segregants were studied for the ability to form tumors in a nude mouse model and 33 microsatellite markers were used to detect critical regions associated with their tumor suppression. Results: Comparison of the tumor suppressive hybrid cell lines and their paired tumor segregants, showed some critical regions were non-randomly eliminated, including the 9q22 .1 and 9q22 .3 regions. Conclusions: These results indicate several chromosome 9q regions may contain important TSGs for EC. These functional complementation experiments are expected to map the putative TSGs of EC.-
dc.languageengen_HK
dc.publisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/en_HK
dc.relation.ispartofJournal of Clinical Oncologyen_HK
dc.titleFunctional investigation of tumor suppressive role of chromosome 9 in esophageal squamous cell carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0732-183X&volume=22&issue=14&spage=852S&epage=852S 9571 Supp. S &date=2004&atitle=Functional+investigation+of+tumor+suppressive+role+of+chromosome+9+in+esophageal+squamous+cell+carcinomaen_HK
dc.identifier.emailTang, JCO: jtang@graduate.hku.hken_HK
dc.identifier.emailSrivastava, G: gopesh@pathology.hku.hken_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.hkuros105098en_HK

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