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Article: Detection of heterozygous XY complete hydatidiform mole by chromosome in situ hybridization

TitleDetection of heterozygous XY complete hydatidiform mole by chromosome in situ hybridization
Authors
Issue Date1994
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
Citation
Gynecologic Oncology, 1994, v. 55 n. 3 I, p. 386-392 How to Cite?
AbstractComplete hydatidiform mole has a substantial risk of developing persistent gestational trophoblastic disease (PTD). Whether heterozygous complete moles, arising from dispermy, have a higher risk of such progression than their homozygous counterparts is controversial. In this study, the frequency of heterozygous XY complete mole in 93 consecutive cases of histologically proven complete moles managed in Hong Kong was assessed by the technique of chromosome in situ hybridization (CISH) using DNA probes specific for the short arm of the Y chromosome. The incidence of Y-chromosome positive complete mole in the groups of patients with spontaneous remissions and the group with PTD with or without metastasis was also compared. The presence of Y chromosome was identified in 6 of the 93 cases (6.5%), and this incidence fell within the range reported in the world literature. Of these 93 patients, 5 patients defaulted follow-up, while 10 patients developed PTD, with evidence of metastasis in 2 of them. The presence of Y chromosome was also assessed in another 15 patients with documented metastatic PTD. It was found that CISH signals for Y chromosome were identified in 5.1% (4/78) of complete moles with spontaneous remission and 8% (2/25) with PTD with or without metastasis (P > 0.05). Y chromosome was detected in 5.9% (1/17) of the complete moles that developed metastasis and in 5.8% (5/86) of the complete moles that either developed spontaneous remission or developed nonmetastatic PTD (P > 0.05). There is no correlation between the presence of Y chromosome and development of persistent gestational trophoblastic disease.
Persistent Identifierhttp://hdl.handle.net/10722/88409
ISSN
2015 Impact Factor: 4.198
2015 SCImago Journal Rankings: 2.284
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-06T09:42:59Z-
dc.date.available2010-09-06T09:42:59Z-
dc.date.issued1994en_HK
dc.identifier.citationGynecologic Oncology, 1994, v. 55 n. 3 I, p. 386-392en_HK
dc.identifier.issn0090-8258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88409-
dc.description.abstractComplete hydatidiform mole has a substantial risk of developing persistent gestational trophoblastic disease (PTD). Whether heterozygous complete moles, arising from dispermy, have a higher risk of such progression than their homozygous counterparts is controversial. In this study, the frequency of heterozygous XY complete mole in 93 consecutive cases of histologically proven complete moles managed in Hong Kong was assessed by the technique of chromosome in situ hybridization (CISH) using DNA probes specific for the short arm of the Y chromosome. The incidence of Y-chromosome positive complete mole in the groups of patients with spontaneous remissions and the group with PTD with or without metastasis was also compared. The presence of Y chromosome was identified in 6 of the 93 cases (6.5%), and this incidence fell within the range reported in the world literature. Of these 93 patients, 5 patients defaulted follow-up, while 10 patients developed PTD, with evidence of metastasis in 2 of them. The presence of Y chromosome was also assessed in another 15 patients with documented metastatic PTD. It was found that CISH signals for Y chromosome were identified in 5.1% (4/78) of complete moles with spontaneous remission and 8% (2/25) with PTD with or without metastasis (P > 0.05). Y chromosome was detected in 5.9% (1/17) of the complete moles that developed metastasis and in 5.8% (5/86) of the complete moles that either developed spontaneous remission or developed nonmetastatic PTD (P > 0.05). There is no correlation between the presence of Y chromosome and development of persistent gestational trophoblastic disease.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygynoen_HK
dc.relation.ispartofGynecologic Oncologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHeterozygote Detectionen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydatidiform Mole - genetics - pathologyen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshNeoplasm Metastasisen_HK
dc.subject.meshNeoplasm Regression, Spontaneousen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshUterine Neoplasms - genetics - pathologyen_HK
dc.subject.meshX Chromosomeen_HK
dc.subject.meshY Chromosome - geneticsen_HK
dc.titleDetection of heterozygous XY complete hydatidiform mole by chromosome in situ hybridizationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0090-8258&volume=55&spage=386&epage=392&date=1994&atitle=Detection+of+heterozygous+XY+complete+hydatidiform+mole+by+chromosome+in+situ+hybridizationen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/gyno.1994.1311en_HK
dc.identifier.pmid7835778-
dc.identifier.scopuseid_2-s2.0-0028630734en_HK
dc.identifier.hkuros5116en_HK
dc.identifier.volume55en_HK
dc.identifier.issue3 Ien_HK
dc.identifier.spage386en_HK
dc.identifier.epage392en_HK
dc.identifier.isiWOS:A1994QG71900013-
dc.publisher.placeUnited Statesen_HK

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