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Article: Detection of trisomy 3 in primary gastric B-cell lymphoma by using chromosome in situ hybridization on paraffin sections

TitleDetection of trisomy 3 in primary gastric B-cell lymphoma by using chromosome in situ hybridization on paraffin sections
Authors
KeywordsChromosome in situ hybridization
CISH
Gastric lymphoma
Interphase cytogenetics
Lymphoma
Trisomy
Trisomy 3
Issue Date1998
PublisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.com
Citation
American Journal Of Clinical Pathology, 1998, v. 110 n. 3, p. 347-353 How to Cite?
AbstractRecent studies in Western populations have shown that trisomy 3 is the most frequent chromosomal abnormality in primary gastric lymphoma (PGL). To study the incidence of trisomy 3 and its implications for the pathogenesis of PGL in Hong Kong, we have applied the technique of chromosome in situ hybridization in 13 cases of PGL by using archival paraffin-embedded tissue sections. Five cases of chronic gastritis were used as controls. Trisomy 3 was found in 9 (69%) of 13 cases, including cases of low-grade lymphoma and high-grade lymphoma with or without a low-grade component. Our findings are similar to the incidence of trisomy 3 reported in the Western literature. The persistent finding of trisomy 3 in various histologic grades of PGL suggests that it may be useful as a clonal marker in this group of neoplasms. Various molecular events involving chromosome 3 may be related to the pathogenesis of this group of lymphomas.
Persistent Identifierhttp://hdl.handle.net/10722/88382
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.129
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorShen, DHen_HK
dc.contributor.authorXu, WSen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorHo, FCSen_HK
dc.date.accessioned2010-09-06T09:42:38Z-
dc.date.available2010-09-06T09:42:38Z-
dc.date.issued1998en_HK
dc.identifier.citationAmerican Journal Of Clinical Pathology, 1998, v. 110 n. 3, p. 347-353en_HK
dc.identifier.issn0002-9173en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88382-
dc.description.abstractRecent studies in Western populations have shown that trisomy 3 is the most frequent chromosomal abnormality in primary gastric lymphoma (PGL). To study the incidence of trisomy 3 and its implications for the pathogenesis of PGL in Hong Kong, we have applied the technique of chromosome in situ hybridization in 13 cases of PGL by using archival paraffin-embedded tissue sections. Five cases of chronic gastritis were used as controls. Trisomy 3 was found in 9 (69%) of 13 cases, including cases of low-grade lymphoma and high-grade lymphoma with or without a low-grade component. Our findings are similar to the incidence of trisomy 3 reported in the Western literature. The persistent finding of trisomy 3 in various histologic grades of PGL suggests that it may be useful as a clonal marker in this group of neoplasms. Various molecular events involving chromosome 3 may be related to the pathogenesis of this group of lymphomas.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Clinical Pathology. The Journal's web site is located at http://www.ajcp.comen_HK
dc.relation.ispartofAmerican Journal of Clinical Pathologyen_HK
dc.subjectChromosome in situ hybridizationen_HK
dc.subjectCISHen_HK
dc.subjectGastric lymphomaen_HK
dc.subjectInterphase cytogeneticsen_HK
dc.subjectLymphomaen_HK
dc.subjectTrisomyen_HK
dc.subjectTrisomy 3en_HK
dc.subject.meshChromosomes, Human, Pair 16 - geneticsen_HK
dc.subject.meshChromosomes, Human, Pair 3 - geneticsen_HK
dc.subject.meshGastritis - genetics - pathologyen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunoenzyme Techniquesen_HK
dc.subject.meshIn Situ Hybridization - methodsen_HK
dc.subject.meshLymphoma, B-Cell - genetics - pathologyen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshStomach Neoplasms - genetics - pathologyen_HK
dc.subject.meshTrisomyen_HK
dc.titleDetection of trisomy 3 in primary gastric B-cell lymphoma by using chromosome in situ hybridization on paraffin sectionsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9173&volume=110&spage=347&epage=353&date=1998&atitle=Detection+of+trisomy+3+in+primary+gastric+B-cell+lymphoma+by+using+chromosome+in+situ+hybridization+on+paraffin+sectionsen_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9728610-
dc.identifier.scopuseid_2-s2.0-0031754270en_HK
dc.identifier.hkuros35070en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031754270&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume110en_HK
dc.identifier.issue3en_HK
dc.identifier.spage347en_HK
dc.identifier.epage353en_HK
dc.identifier.isiWOS:000075533800010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, Y=7601327404en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridChan, ACL=16047349300en_HK
dc.identifier.scopusauthoridShen, DH=7401738584en_HK
dc.identifier.scopusauthoridXu, WS=24475895600en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridHo, FCS=7103408147en_HK

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