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Article: Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies

TitleFrequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies
Authors
Issue Date2007
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2007, v. 136 n. 6, p. 829-832 How to Cite?
AbstractEpigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.
Persistent Identifierhttp://hdl.handle.net/10722/88367
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYing, Jen_HK
dc.contributor.authorGao, Zen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorMurray, PGen_HK
dc.contributor.authorGoh, HKen_HK
dc.contributor.authorLim, CYen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorMarafioti, Ten_HK
dc.contributor.authorMason, DYen_HK
dc.contributor.authorAmbinder, RFen_HK
dc.contributor.authorChan, ATCen_HK
dc.contributor.authorTao, Qen_HK
dc.date.accessioned2010-09-06T09:42:27Z-
dc.date.available2010-09-06T09:42:27Z-
dc.date.issued2007en_HK
dc.identifier.citationBritish Journal Of Haematology, 2007, v. 136 n. 6, p. 829-832en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88367-
dc.description.abstractEpigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we identified PCDH10 as a methylated TSG in carcinomas. Here, we detected its frequent silencing and methylation in lymphoma cell lines including 100% Burkitt, 100% diffuse large B cell, 86% Hodgkin, 100% nasal natural killer/T-cell lymphoma and 1/3 of leukaemia cell lines, and in primary tumours but not in normal peripheral blood mononuclear cells or lymph nodes. PCDH10 silencing could be reversed by demethylation with 5-aza-2′- deoxycytidine. Methylation was further detected in 14% of Hodgkin lymphoma sera. Thus, PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshBurkitt Lymphoma - geneticsen_HK
dc.subject.meshCadherins - geneticsen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshCpG Islandsen_HK
dc.subject.meshDNA Methylationen_HK
dc.subject.meshEpigenesis, Geneticen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshGene Silencingen_HK
dc.subject.meshHematologic Neoplasms - geneticsen_HK
dc.subject.meshHodgkin Disease - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLeukemia - geneticsen_HK
dc.subject.meshLymphoma, Large B-Cell, Diffuse - geneticsen_HK
dc.subject.meshLymphoma, T-Cell - geneticsen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshTumor Markers, Biologicalen_HK
dc.titleFrequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignanciesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1048&volume=136&issue=6&spage=829&epage=32&date=2007&atitle=Frequent+epigenetic+silencing+of+protocadherin+10+by+methylation+in+multiple+haematologic+malignanciesen_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.emailWang, Y:cdwyj@yahoo.comen_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityWang, Y=rp00801en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2141.2007.06512.xen_HK
dc.identifier.pmid17341268-
dc.identifier.scopuseid_2-s2.0-33847379460en_HK
dc.identifier.hkuros132801en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33847379460&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume136en_HK
dc.identifier.issue6en_HK
dc.identifier.spage829en_HK
dc.identifier.epage832en_HK
dc.identifier.isiWOS:000244611600007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.citeulike1141153-

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