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Article: Expression of cytokine and chemokine genes in Epstein-Barr virus-associated nasopharyngeal carcinoma: Comparison with Hodgkin's disease

TitleExpression of cytokine and chemokine genes in Epstein-Barr virus-associated nasopharyngeal carcinoma: Comparison with Hodgkin's disease
Authors
Issue Date2001
PublisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130
Citation
Journal Of Pathology, 2001, v. 194 n. 2, p. 145-151 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) and Hodgkin's disease (HD) are characterized by their association with Epstein-Barr virus (EBV) and the presence of an intense lymphoid stroma, consisting of T lymphocytes and other reactive cells. In both entities, the tumour cells express viral proteins known to provide target epitopes for cytotoxic T-cells (CTLs), yet in vivo, the tumour cells appear to escape CTL recognition. A comparative in situ hybridization study of cytokine and chemokine gene expression in NPC and HD has been undertaken, focusing on cytokines which are known to be inducible by EBV in vitro. Hodgkin and Reed-Sternberg (HRS) cells expressed interleukin (IL)-6, IL-8, and IL-10, and the thymus and activation regulated chemokine (TARC) in 15/22, 0/22, 5/22, and 16/21 cases, respectively. In NPC, the epithelial tumour cells showed expression of IL-6 in 3/43 cases and of IL-8 in 2/40 cases. There was no detectable expression of IL-10 and TARC in these cases. These data confirm that HRS cells frequently express cytokine and chemokine genes and suggest that this may enable HRS cells to modulate the immune response in their microenvironment and to escape CTL detection. In contrast, NPC tumour cells show only rare expression of IL-6 and IL-8 and no detectable expression of IL-10 and TARC. Thus, the results suggest that the mechanisms employed by the EBV-positive tumour cells to escape immune recognition and destruction differ between HD and NPC. Copyright © 2001 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/88366
ISSN
2015 Impact Factor: 7.381
2015 SCImago Journal Rankings: 4.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBeck, Aen_HK
dc.contributor.authorPzolt, Den_HK
dc.contributor.authorGrabenbauer, GGen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorHerbst, Hen_HK
dc.contributor.authorYoung, LSen_HK
dc.contributor.authorNiedobitek, Gen_HK
dc.date.accessioned2010-09-06T09:42:26Z-
dc.date.available2010-09-06T09:42:26Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Pathology, 2001, v. 194 n. 2, p. 145-151en_HK
dc.identifier.issn0022-3417en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88366-
dc.description.abstractNasopharyngeal carcinoma (NPC) and Hodgkin's disease (HD) are characterized by their association with Epstein-Barr virus (EBV) and the presence of an intense lymphoid stroma, consisting of T lymphocytes and other reactive cells. In both entities, the tumour cells express viral proteins known to provide target epitopes for cytotoxic T-cells (CTLs), yet in vivo, the tumour cells appear to escape CTL recognition. A comparative in situ hybridization study of cytokine and chemokine gene expression in NPC and HD has been undertaken, focusing on cytokines which are known to be inducible by EBV in vitro. Hodgkin and Reed-Sternberg (HRS) cells expressed interleukin (IL)-6, IL-8, and IL-10, and the thymus and activation regulated chemokine (TARC) in 15/22, 0/22, 5/22, and 16/21 cases, respectively. In NPC, the epithelial tumour cells showed expression of IL-6 in 3/43 cases and of IL-8 in 2/40 cases. There was no detectable expression of IL-10 and TARC in these cases. These data confirm that HRS cells frequently express cytokine and chemokine genes and suggest that this may enable HRS cells to modulate the immune response in their microenvironment and to escape CTL detection. In contrast, NPC tumour cells show only rare expression of IL-6 and IL-8 and no detectable expression of IL-10 and TARC. Thus, the results suggest that the mechanisms employed by the EBV-positive tumour cells to escape immune recognition and destruction differ between HD and NPC. Copyright © 2001 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130en_HK
dc.relation.ispartofJournal of Pathologyen_HK
dc.rightsJournal of Pathology. Copyright © John Wiley & Sons Ltd.en_HK
dc.subject.meshCarcinoma - genetics - immunology - virologyen_HK
dc.subject.meshCarcinoma, Squamous Cell - genetics - immunology - virologyen_HK
dc.subject.meshChemokine CCL17en_HK
dc.subject.meshChemokines, CC - analysis - geneticsen_HK
dc.subject.meshCytokines - geneticsen_HK
dc.subject.meshEpstein-Barr Virus Infections - genetics - immunologyen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshHodgkin Disease - genetics - immunology - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistry - methodsen_HK
dc.subject.meshIn Situ Hybridization - methodsen_HK
dc.subject.meshInterleukin-10 - analysis - geneticsen_HK
dc.subject.meshInterleukin-6 - analysis - geneticsen_HK
dc.subject.meshInterleukin-8 - analysis - geneticsen_HK
dc.subject.meshNasopharyngeal Neoplasms - genetics - immunology - virologyen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshReed-Sternberg Cells - immunologyen_HK
dc.titleExpression of cytokine and chemokine genes in Epstein-Barr virus-associated nasopharyngeal carcinoma: Comparison with Hodgkin's diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3417&volume=194&issue=2&spage=145&epage=151&date=2001&atitle=Expression+of+cytokine+and+chemokine+genes+in+Epstein-Barr+virus-associated+nasopharyngeal+carcinoma:+comparison+with+Hodgkin%27s+diseaseen_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/path.867en_HK
dc.identifier.pmid11400141-
dc.identifier.scopuseid_2-s2.0-0034994445en_HK
dc.identifier.hkuros59742en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034994445&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume194en_HK
dc.identifier.issue2en_HK
dc.identifier.spage145en_HK
dc.identifier.epage151en_HK
dc.identifier.isiWOS:000169023200002-
dc.publisher.placeUnited Kingdomen_HK

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