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Article: The association of squamous cell carcinomas of the nasopharynx with epstein-barr virus shows geographical variation reminiscent of burkitt's lymphoma

TitleThe association of squamous cell carcinomas of the nasopharynx with epstein-barr virus shows geographical variation reminiscent of burkitt's lymphoma
Authors
Issue Date1997
PublisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130
Citation
Journal Of Pathology, 1997, v. 183 n. 2, p. 164-168 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is rare in most parts of the world but occurs with high incidence in certain regions, such as South-East Asia. Two major histological types of NPC are recognized, non-keratinizing carcinoma and squamous cell carcinoma. Non-keratinizing NPCs, which include undifferentiated NPC, are invariably associated with Epstein-Bart virus (EBV) infection, regardless of the geographical or ethnic origin of the patients. By contrast, conflicting results have been published concerning a possible association of squamous cell NPC with the virus. To address this question, squamous cell NPCs have been collated from an area where NPC is endemic, Hong Kong, and from two regions where NPC occurs with a lower incidence, Chengdu, PR China, and Birmingham, United Kingdom. In situ hybridization for the detection of the small EBV-encoded nuclear RNAs (EBERs) demonstrated that all 22 cases from Hong Kong were EBV-positive. By contrast, EBV was detectable in 7 of 19 cases from central China, and in 3 of 7 cases from the U.K. Expression of the virus-encoded latent membrane protein 1 (LMP1) was detected in 3 of 32 EBV-positive squamous cell NPCs. These results indicate that the association of squamous cell NPCs with EBV shows geographical variability in a manner which is reminiscent of the situation encountered in Burkitt's lymphoma. This suggests that squamous cell NPCs are a pathogenetically heterogeneous group of tumours distinct from non-keratinizing NPCs.
Persistent Identifierhttp://hdl.handle.net/10722/88309
ISSN
2015 Impact Factor: 7.381
2015 SCImago Journal Rankings: 4.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorAgathanggelou, Aen_HK
dc.contributor.authorFung, Ken_HK
dc.contributor.authorXiangguo, Zen_HK
dc.contributor.authorNiedobitek, Gen_HK
dc.date.accessioned2010-09-06T09:41:41Z-
dc.date.available2010-09-06T09:41:41Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal Of Pathology, 1997, v. 183 n. 2, p. 164-168en_HK
dc.identifier.issn0022-3417en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88309-
dc.description.abstractNasopharyngeal carcinoma (NPC) is rare in most parts of the world but occurs with high incidence in certain regions, such as South-East Asia. Two major histological types of NPC are recognized, non-keratinizing carcinoma and squamous cell carcinoma. Non-keratinizing NPCs, which include undifferentiated NPC, are invariably associated with Epstein-Bart virus (EBV) infection, regardless of the geographical or ethnic origin of the patients. By contrast, conflicting results have been published concerning a possible association of squamous cell NPC with the virus. To address this question, squamous cell NPCs have been collated from an area where NPC is endemic, Hong Kong, and from two regions where NPC occurs with a lower incidence, Chengdu, PR China, and Birmingham, United Kingdom. In situ hybridization for the detection of the small EBV-encoded nuclear RNAs (EBERs) demonstrated that all 22 cases from Hong Kong were EBV-positive. By contrast, EBV was detectable in 7 of 19 cases from central China, and in 3 of 7 cases from the U.K. Expression of the virus-encoded latent membrane protein 1 (LMP1) was detected in 3 of 32 EBV-positive squamous cell NPCs. These results indicate that the association of squamous cell NPCs with EBV shows geographical variability in a manner which is reminiscent of the situation encountered in Burkitt's lymphoma. This suggests that squamous cell NPCs are a pathogenetically heterogeneous group of tumours distinct from non-keratinizing NPCs.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130en_HK
dc.relation.ispartofJournal of Pathologyen_HK
dc.rightsJournal of Pathology. Copyright © John Wiley & Sons Ltd.en_HK
dc.subject.meshBurkitt Lymphoma - virologyen_HK
dc.subject.meshCarcinoma, Squamous Cell - epidemiology - virologyen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshEngland - epidemiologyen_HK
dc.subject.meshHerpesviridae Infections - complications - epidemiologyen_HK
dc.subject.meshHerpesvirus 4, Humanen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshNasopharyngeal Neoplasms - epidemiology - virologyen_HK
dc.subject.meshTumor Virus Infections - complications - epidemiologyen_HK
dc.titleThe association of squamous cell carcinomas of the nasopharynx with epstein-barr virus shows geographical variation reminiscent of burkitt's lymphomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3417&volume=183&spage=164&epage=168&date=1997&atitle=The+association+of+squamous+cell+carcinomas+of+the+nasopharynx+with+Epstein-Barr+virus+shows+geographical+variation+reminiscent+of+burkitt%27s+lymphomaen_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/(SICI)1096-9896(199710)183:2<164::AID-PATH919>3.0.CO;2-Jen_HK
dc.identifier.pmid9390028-
dc.identifier.scopuseid_2-s2.0-0030768465en_HK
dc.identifier.hkuros34033en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030768465&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume183en_HK
dc.identifier.issue2en_HK
dc.identifier.spage164en_HK
dc.identifier.epage168en_HK
dc.identifier.isiWOS:A1997YA17000008-
dc.publisher.placeUnited Kingdomen_HK

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