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Article: Pathogenesis of gastric lymphoma: The enigma in Hong Kong

TitlePathogenesis of gastric lymphoma: The enigma in Hong Kong
Authors
Issue Date1997
PublisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/
Citation
Annals Of Oncology, 1997, v. 8 SUPPL. 2, p. S41-S44 How to Cite?
AbstractBackground: Helicobacter pylori (H. pylori) infection has been postulated to be a pathogenetic factor in gastric lymphoma. However, the etiological factors for gastric lymphoma could vary in different populations. Materials and methods: We looked for histological evidence of H. pylori infection in 53 gastrectomy specimens from Hong Kong Chinese patients with primary gastric B-lymphoma. We also screened for Epstein-Barr virus (EBV) in these cases using in situ hybridization with oligonucleotide probes for EBV- encoded small RNA1 and 2. Results: H. pylori was found in 29 of 53 (55%), including 8 of 13 (62%) cases of low-grade lymphoma of mucosa-associated lymphoid tissue (MALT) type. These infection rates in gastric lymphoma are lower than those reported in Western populations (80% 100%) and comparable to that found in healthy Chinese blood donors (55%) or in non-ulcer dyspeptic patients (52% 57%). EBV was found in tumor cells only in one case of high- grade gastric lymphoma with low-grade MALT component which was H. pylori- negative, and in occasional nontumor lymphoid cells in 7 other cases. Conclusions: These results suggest that (1) the role of H. pylori in pathogenesis of gastric lymphoma may vary in different populations: (2) very few gastric lymphomas are associated with EBV; (3) not all low-grade gastric MALT lymphomas are H. pylori-dependent.
Persistent Identifierhttp://hdl.handle.net/10722/88290
ISSN
2015 Impact Factor: 9.269
2015 SCImago Journal Rankings: 4.362
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, WSen_HK
dc.contributor.authorHo, FCSen_HK
dc.contributor.authorHo, Jen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.date.accessioned2010-09-06T09:41:25Z-
dc.date.available2010-09-06T09:41:25Z-
dc.date.issued1997en_HK
dc.identifier.citationAnnals Of Oncology, 1997, v. 8 SUPPL. 2, p. S41-S44en_HK
dc.identifier.issn0923-7534en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88290-
dc.description.abstractBackground: Helicobacter pylori (H. pylori) infection has been postulated to be a pathogenetic factor in gastric lymphoma. However, the etiological factors for gastric lymphoma could vary in different populations. Materials and methods: We looked for histological evidence of H. pylori infection in 53 gastrectomy specimens from Hong Kong Chinese patients with primary gastric B-lymphoma. We also screened for Epstein-Barr virus (EBV) in these cases using in situ hybridization with oligonucleotide probes for EBV- encoded small RNA1 and 2. Results: H. pylori was found in 29 of 53 (55%), including 8 of 13 (62%) cases of low-grade lymphoma of mucosa-associated lymphoid tissue (MALT) type. These infection rates in gastric lymphoma are lower than those reported in Western populations (80% 100%) and comparable to that found in healthy Chinese blood donors (55%) or in non-ulcer dyspeptic patients (52% 57%). EBV was found in tumor cells only in one case of high- grade gastric lymphoma with low-grade MALT component which was H. pylori- negative, and in occasional nontumor lymphoid cells in 7 other cases. Conclusions: These results suggest that (1) the role of H. pylori in pathogenesis of gastric lymphoma may vary in different populations: (2) very few gastric lymphomas are associated with EBV; (3) not all low-grade gastric MALT lymphomas are H. pylori-dependent.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/en_HK
dc.relation.ispartofAnnals of Oncologyen_HK
dc.rightsAnnals of Oncology. Copyright © Oxford University Press.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBurkitt Lymphoma - epidemiology - virologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHerpesvirus 4, Human - isolation & purificationen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshStomach Neoplasms - virologyen_HK
dc.subject.meshTumor Virus Infections - epidemiology - virologyen_HK
dc.titlePathogenesis of gastric lymphoma: The enigma in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0923-7534&volume=8 &issue=2&spage=S41 &epage= S44&date=1997&atitle=Pathogenesis+of+Gastric+Lymphoma:+The+Enigma+in+Hong+Kongen_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9209639-
dc.identifier.scopuseid_2-s2.0-0030876937en_HK
dc.identifier.hkuros38473en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030876937&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issueSUPPL. 2en_HK
dc.identifier.spageS41en_HK
dc.identifier.epageS44en_HK
dc.identifier.isiWOS:A1997XH39900009-
dc.publisher.placeUnited Kingdomen_HK

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