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Article: Apoptotic and proliferative activities in first trimester placentae

TitleApoptotic and proliferative activities in first trimester placentae
Authors
Issue Date1999
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placenta
Citation
Placenta, 1999, v. 20 n. 2-3, p. 223-227 How to Cite?
AbstractApoptosis and cell proliferation are widely recognized to be important physiological processes which together maintain tissue homeostasis. The apoptotic and proliferative processes in 38 first trimester placentae were quantified using terminal deoxynucleotidyl transferase mediated dUTP nick end-labelling (TUNEL) and an antibody against Ki-67 antigen, respectively. In 14 cases, the estimation of apoptotic index was repeated with sections stained with haematoxylin and eosin by identifying the morphological features of apoptosis. We found that the indices obtained by either method correlated well with each other although a lower rate was obtained with the haematoxylin and eosin stained sections. Apoptosis was found in clusters mainly in syncytiotrophoblasts in association with fibrinoid deposits while proliferating activity was limited to cytotrophoblasts and stromal cells. A significant inverse correlation was observed between the proliferative index and gestational age as well as the apoptotic index. While the extent of apoptosis decreased with advanced gestational age, the correlation was not statistically significant. These findings provide a potential explanation for villous remodelling during trophoblastic invasion in early pregnancy.
Persistent Identifierhttp://hdl.handle.net/10722/88289
ISSN
2015 Impact Factor: 2.972
2015 SCImago Journal Rankings: 1.608
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, CCWen_HK
dc.contributor.authorT T, Len_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-06T09:41:25Z-
dc.date.available2010-09-06T09:41:25Z-
dc.date.issued1999en_HK
dc.identifier.citationPlacenta, 1999, v. 20 n. 2-3, p. 223-227en_HK
dc.identifier.issn0143-4004en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88289-
dc.description.abstractApoptosis and cell proliferation are widely recognized to be important physiological processes which together maintain tissue homeostasis. The apoptotic and proliferative processes in 38 first trimester placentae were quantified using terminal deoxynucleotidyl transferase mediated dUTP nick end-labelling (TUNEL) and an antibody against Ki-67 antigen, respectively. In 14 cases, the estimation of apoptotic index was repeated with sections stained with haematoxylin and eosin by identifying the morphological features of apoptosis. We found that the indices obtained by either method correlated well with each other although a lower rate was obtained with the haematoxylin and eosin stained sections. Apoptosis was found in clusters mainly in syncytiotrophoblasts in association with fibrinoid deposits while proliferating activity was limited to cytotrophoblasts and stromal cells. A significant inverse correlation was observed between the proliferative index and gestational age as well as the apoptotic index. While the extent of apoptosis decreased with advanced gestational age, the correlation was not statistically significant. These findings provide a potential explanation for villous remodelling during trophoblastic invasion in early pregnancy.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/placentaen_HK
dc.relation.ispartofPlacentaen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGestational Ageen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Nick-End Labelingen_HK
dc.subject.meshKi-67 Antigen - analysisen_HK
dc.subject.meshPlacenta - cytologyen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPregnancy Trimester, Firsten_HK
dc.subject.meshTrophoblasts - cytology - immunologyen_HK
dc.titleApoptotic and proliferative activities in first trimester placentaeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-4004&volume=20&spage=223&epage=227&date=1998&atitle=Apoptotic+and+proliferative+activities+in+first+trimester+placentaeen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/plac.1998.0375en_HK
dc.identifier.pmid10195745-
dc.identifier.scopuseid_2-s2.0-0033104881en_HK
dc.identifier.hkuros41791en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033104881&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue2-3en_HK
dc.identifier.spage223en_HK
dc.identifier.epage227en_HK
dc.identifier.isiWOS:000079180300014-
dc.publisher.placeUnited Kingdomen_HK

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