Article: Kaposiform hemangioendothelioma: Five patients with cutaneous lesion and long follow-up

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TitleKaposiform hemangioendothelioma: Five patients with cutaneous lesion and long follow-up
AuthorsMacMoune Lai, F4
To, KF4
Choi, PCL4
Leung, PC4
Kumta, SM4
Yuen, PPM4
Lam, WY1
Cheung, ANY2
Allen, PW3
Issue Date2001
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
CitationModern Pathology, 2001, v. 14 n. 11, p. 1087-1092 [How to Cite?]
DOI: http://dx.doi.org/10.1038/modpathol.3880441
AbstractKaposiform hemangioendothelioma is a rare locally aggressive vascular tumor of the skin, deep soft tissue, and bone in children, characterized by infiltrating nodules and sheets of spindle cells, and unmistakable resemblance to Kaposi's sarcoma. More than 60 patients with such tumor have been reported so far, and while many have died as a result of extensive disease and severe coagulopathy, the long-term biologic behavior of this tumor remains undetermined. We describe five patients with kaposiform hemangioendothelioma and a mean follow-up of 19 years, ranging from 8 to 35 years. This report emphasizes on the importance of cutaneous lesions being the most commonly affected site, but also for its clinical diversity. Early diagnosis is possible even for a small skin lesion, which may be critical for the treatment of a potentially fatal deep-seated extensive tumor. All five patients are well, and three of them with persistent vascular tumor, which has carried two patients from childhood to adult. Although the behavior of this tumor might have been modified by radiation or interferon in three patients, this series indicates that kaposiform hemangioendothelioma is incapable of metastasis, despite a protracted course of many decades with no tendency for spontaneous regression.
ISSN0893-3952
2011 Impact Factor: 4.792
2011 SCImago Journal Rankings: 0.565
DOIhttp://dx.doi.org/10.1038/modpathol.3880441
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorMacMoune Lai, F
dc.contributor.authorTo, KF
dc.contributor.authorChoi, PCL
dc.contributor.authorLeung, PC
dc.contributor.authorKumta, SM
dc.contributor.authorYuen, PPM
dc.contributor.authorLam, WY
dc.contributor.authorCheung, ANY
dc.contributor.authorAllen, PW
dc.date.accessioned2010-09-06T09:41:15Z
dc.date.available2010-09-06T09:41:15Z
dc.date.issued2001
dc.description.abstractKaposiform hemangioendothelioma is a rare locally aggressive vascular tumor of the skin, deep soft tissue, and bone in children, characterized by infiltrating nodules and sheets of spindle cells, and unmistakable resemblance to Kaposi's sarcoma. More than 60 patients with such tumor have been reported so far, and while many have died as a result of extensive disease and severe coagulopathy, the long-term biologic behavior of this tumor remains undetermined. We describe five patients with kaposiform hemangioendothelioma and a mean follow-up of 19 years, ranging from 8 to 35 years. This report emphasizes on the importance of cutaneous lesions being the most commonly affected site, but also for its clinical diversity. Early diagnosis is possible even for a small skin lesion, which may be critical for the treatment of a potentially fatal deep-seated extensive tumor. All five patients are well, and three of them with persistent vascular tumor, which has carried two patients from childhood to adult. Although the behavior of this tumor might have been modified by radiation or interferon in three patients, this series indicates that kaposiform hemangioendothelioma is incapable of metastasis, despite a protracted course of many decades with no tendency for spontaneous regression.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationModern Pathology, 2001, v. 14 n. 11, p. 1087-1092 [How to Cite?]
DOI: http://dx.doi.org/10.1038/modpathol.3880441
dc.identifier.citeulike10924596
dc.identifier.doihttp://dx.doi.org/10.1038/modpathol.3880441
dc.identifier.epage1092
dc.identifier.hkuros83963
dc.identifier.issn0893-3952
2011 Impact Factor: 4.792
2011 SCImago Journal Rankings: 0.565
dc.identifier.issue11
dc.identifier.openurl
dc.identifier.pmid11706068
dc.identifier.scopuseid_2-s2.0-0035163732
dc.identifier.spage1087
dc.identifier.urihttp://hdl.handle.net/10722/88278
dc.identifier.volume14
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofModern Pathology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshChild
dc.subject.meshDiagnosis, Differential
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHemangioendothelioma - pathology
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshSarcoma, Kaposi - pathology
dc.subject.meshSkin - pathology
dc.subject.meshSkin Neoplasms - pathology
dc.subject.meshTime Factors
dc.titleKaposiform hemangioendothelioma: Five patients with cutaneous lesion and long follow-up
dc.typeArticle
Author Affiliations
  1. Tuen Mun Hospital
  2. The University of Hong Kong
  3. Flinders Medical Centre
  4. Chinese University of Hong Kong