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Article: Kaposiform hemangioendothelioma: Five patients with cutaneous lesion and long follow-up
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TitleKaposiform hemangioendothelioma: Five patients with cutaneous lesion and long follow-up
 
AuthorsMacMoune Lai, F4
To, KF4
Choi, PCL4
Leung, PC4
Kumta, SM4
Yuen, PPM4
Lam, WY2
Cheung, ANY1
Allen, PW3
 
Issue Date2001
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
 
CitationModern Pathology, 2001, v. 14 n. 11, p. 1087-1092 [How to Cite?]
DOI: http://dx.doi.org/10.1038/modpathol.3880441
 
AbstractKaposiform hemangioendothelioma is a rare locally aggressive vascular tumor of the skin, deep soft tissue, and bone in children, characterized by infiltrating nodules and sheets of spindle cells, and unmistakable resemblance to Kaposi's sarcoma. More than 60 patients with such tumor have been reported so far, and while many have died as a result of extensive disease and severe coagulopathy, the long-term biologic behavior of this tumor remains undetermined. We describe five patients with kaposiform hemangioendothelioma and a mean follow-up of 19 years, ranging from 8 to 35 years. This report emphasizes on the importance of cutaneous lesions being the most commonly affected site, but also for its clinical diversity. Early diagnosis is possible even for a small skin lesion, which may be critical for the treatment of a potentially fatal deep-seated extensive tumor. All five patients are well, and three of them with persistent vascular tumor, which has carried two patients from childhood to adult. Although the behavior of this tumor might have been modified by radiation or interferon in three patients, this series indicates that kaposiform hemangioendothelioma is incapable of metastasis, despite a protracted course of many decades with no tendency for spontaneous regression.
 
ISSN0893-3952
2012 Impact Factor: 5.253
2012 SCImago Journal Rankings: 2.127
 
DOIhttp://dx.doi.org/10.1038/modpathol.3880441
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorMacMoune Lai, F
 
dc.contributor.authorTo, KF
 
dc.contributor.authorChoi, PCL
 
dc.contributor.authorLeung, PC
 
dc.contributor.authorKumta, SM
 
dc.contributor.authorYuen, PPM
 
dc.contributor.authorLam, WY
 
dc.contributor.authorCheung, ANY
 
dc.contributor.authorAllen, PW
 
dc.date.accessioned2010-09-06T09:41:15Z
 
dc.date.available2010-09-06T09:41:15Z
 
dc.date.issued2001
 
dc.description.abstractKaposiform hemangioendothelioma is a rare locally aggressive vascular tumor of the skin, deep soft tissue, and bone in children, characterized by infiltrating nodules and sheets of spindle cells, and unmistakable resemblance to Kaposi's sarcoma. More than 60 patients with such tumor have been reported so far, and while many have died as a result of extensive disease and severe coagulopathy, the long-term biologic behavior of this tumor remains undetermined. We describe five patients with kaposiform hemangioendothelioma and a mean follow-up of 19 years, ranging from 8 to 35 years. This report emphasizes on the importance of cutaneous lesions being the most commonly affected site, but also for its clinical diversity. Early diagnosis is possible even for a small skin lesion, which may be critical for the treatment of a potentially fatal deep-seated extensive tumor. All five patients are well, and three of them with persistent vascular tumor, which has carried two patients from childhood to adult. Although the behavior of this tumor might have been modified by radiation or interferon in three patients, this series indicates that kaposiform hemangioendothelioma is incapable of metastasis, despite a protracted course of many decades with no tendency for spontaneous regression.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationModern Pathology, 2001, v. 14 n. 11, p. 1087-1092 [How to Cite?]
DOI: http://dx.doi.org/10.1038/modpathol.3880441
 
dc.identifier.citeulike10924596
 
dc.identifier.doihttp://dx.doi.org/10.1038/modpathol.3880441
 
dc.identifier.epage1092
 
dc.identifier.hkuros83963
 
dc.identifier.issn0893-3952
2012 Impact Factor: 5.253
2012 SCImago Journal Rankings: 2.127
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmid11706068
 
dc.identifier.scopuseid_2-s2.0-0035163732
 
dc.identifier.spage1087
 
dc.identifier.urihttp://hdl.handle.net/10722/88278
 
dc.identifier.volume14
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/modpathol/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofModern Pathology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshChild
 
dc.subject.meshDiagnosis, Differential
 
dc.subject.meshFemale
 
dc.subject.meshFollow-Up Studies
 
dc.subject.meshHemangioendothelioma - pathology
 
dc.subject.meshHumans
 
dc.subject.meshInfant
 
dc.subject.meshMale
 
dc.subject.meshSarcoma, Kaposi - pathology
 
dc.subject.meshSkin - pathology
 
dc.subject.meshSkin Neoplasms - pathology
 
dc.subject.meshTime Factors
 
dc.titleKaposiform hemangioendothelioma: Five patients with cutaneous lesion and long follow-up
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Tuen Mun Hospital
  3. Flinders Medical Centre
  4. Chinese University of Hong Kong