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Article: Integration of endochondral bone grafts in the presence of demineralized bone matrix

TitleIntegration of endochondral bone grafts in the presence of demineralized bone matrix
Authors
KeywordsComposite endochondral bone/demineralized bone matrix
Demineralized bone matrix
Endochondral bone
Issue Date1996
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijom
Citation
International Journal Of Oral And Maxillofacial Surgery, 1996, v. 25 n. 4, p. 311-318 How to Cite?
AbstractThe use of endochondral bone grafts (EC) and demineralized bone matrix (DBM), which contains a potent osteoinductive matrix, may promote the repair of nonregenerative defects. The purpose of the current work is to assess qualitatively and quantitatively the effect of DBM on the healing of EC bone grafts and to compare it to the healing of EC bone grafts alone. Twenty-four defects in rabbit skulls were filled with EC bone grafts alone, DBM alone, or combined EC and DBM. Histologic and immunohistologic changes were examined in 2 weeks. The amount of new bone formation was quantified by image analysis. Healing of all the groups was characterized by the presence of a cartilage intermediate stage. In the EC bone grafts alone, healing was localized to the host bone/graft interface. In the composite group, amalgamation of the new bone, DBM, and bone graft progressed throughout the whole width and depth of the defect, uniting the graft to the recipient bed. The amount of new bone formed was significantly greater (47%) in the composite group than the EC group. In conclusion, DBM powder augments the bone-induction capacity of the recipient bed as well as the bone graft. The composite EC bone grafts and added DBM possess properties required for an effective graft material and merit further clinical evaluation.
Persistent Identifierhttp://hdl.handle.net/10722/88156
ISSN
2015 Impact Factor: 1.563
2015 SCImago Journal Rankings: 0.854
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorLie Ken Jie, RKPen_HK
dc.date.accessioned2010-09-06T09:39:34Z-
dc.date.available2010-09-06T09:39:34Z-
dc.date.issued1996en_HK
dc.identifier.citationInternational Journal Of Oral And Maxillofacial Surgery, 1996, v. 25 n. 4, p. 311-318en_HK
dc.identifier.issn0901-5027en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88156-
dc.description.abstractThe use of endochondral bone grafts (EC) and demineralized bone matrix (DBM), which contains a potent osteoinductive matrix, may promote the repair of nonregenerative defects. The purpose of the current work is to assess qualitatively and quantitatively the effect of DBM on the healing of EC bone grafts and to compare it to the healing of EC bone grafts alone. Twenty-four defects in rabbit skulls were filled with EC bone grafts alone, DBM alone, or combined EC and DBM. Histologic and immunohistologic changes were examined in 2 weeks. The amount of new bone formation was quantified by image analysis. Healing of all the groups was characterized by the presence of a cartilage intermediate stage. In the EC bone grafts alone, healing was localized to the host bone/graft interface. In the composite group, amalgamation of the new bone, DBM, and bone graft progressed throughout the whole width and depth of the defect, uniting the graft to the recipient bed. The amount of new bone formed was significantly greater (47%) in the composite group than the EC group. In conclusion, DBM powder augments the bone-induction capacity of the recipient bed as well as the bone graft. The composite EC bone grafts and added DBM possess properties required for an effective graft material and merit further clinical evaluation.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijomen_HK
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgeryen_HK
dc.subjectComposite endochondral bone/demineralized bone matrixen_HK
dc.subjectDemineralized bone matrixen_HK
dc.subjectEndochondral boneen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Demineralization Techniqueen_HK
dc.subject.meshBone Matrix - transplantationen_HK
dc.subject.meshBone Morphogenetic Proteins - pharmacologyen_HK
dc.subject.meshBone Transplantation - methods - physiologyen_HK
dc.subject.meshCartilage - transplantationen_HK
dc.subject.meshOsteogenesis - drug effectsen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshWound Healing - drug effectsen_HK
dc.titleIntegration of endochondral bone grafts in the presence of demineralized bone matrixen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0901-5027&volume=25&spage=10&epage=18&date=1996&atitle=Integration+of+endochondral+bone+grafts+in+the+presence+of+demineralized+bone+matrixen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8910120-
dc.identifier.scopuseid_2-s2.0-0030203588en_HK
dc.identifier.hkuros14891en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030203588&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue4en_HK
dc.identifier.spage311en_HK
dc.identifier.epage318en_HK
dc.identifier.isiWOS:A1996VP10100014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridLie Ken Jie, RKP=6506352151en_HK

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