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Article: Genetic analysis of aldose reductase in diabetic complications

TitleGenetic analysis of aldose reductase in diabetic complications
Authors
KeywordsAldose reductase
Diabetic complications
DNA polymorphism
Gene knockout
Transgenic
Issue Date2003
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmc/index.htm
Citation
Current Medicinal Chemistry, 2003, v. 10 n. 15, p. 1375-1387 How to Cite?
AbstractDiabetes Mellitus is an increasing concern, worldwide in terms of health. Long-term diabetes often leads to secondary diseases such as cataract, retinopathy, neuropathy, nephropathy, and cardiovascular diseases. The enzyme aldose reductase (AR) has been implicated in the pathogenesis of some of these diseases and inhibitors of AR (ARIs) were effective in preventing some of the diabetic complications in animal models. However, clinical trials of these drugs were disappointing, casting doubt on the role of AR in these diseases. This review focuses on the recent studies using transgenic and gene knockout mice to analyze the role of AR in diabetic cataract and neuropathy. These studies clearly demonstrated that AR is crucial to the pathogenesis of these diseases, and that the mechanism leading to diabetic cataract may be different from that which causes diabetic neuropathy. A number of studies showed that there is a correlation between AR gene markers and susceptibility to develop complications among diabetic patients, suggesting that AR is also involved in the pathogenesis of diabetic complications in human. Together, these genetic studies strongly indicate that AR is an important target for the prevention of diabetic complications in human. This may provide impetus to develop more effective ARIs and to conduct better-designed clinical trials for ARIs in the prevention and treatment of these diseases.
Persistent Identifierhttp://hdl.handle.net/10722/88050
ISSN
2015 Impact Factor: 3.455
2015 SCImago Journal Rankings: 0.842
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChung, SSMen_HK
dc.contributor.authorChung, SKen_HK
dc.date.accessioned2010-09-06T09:37:59Z-
dc.date.available2010-09-06T09:37:59Z-
dc.date.issued2003en_HK
dc.identifier.citationCurrent Medicinal Chemistry, 2003, v. 10 n. 15, p. 1375-1387en_HK
dc.identifier.issn0929-8673en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88050-
dc.description.abstractDiabetes Mellitus is an increasing concern, worldwide in terms of health. Long-term diabetes often leads to secondary diseases such as cataract, retinopathy, neuropathy, nephropathy, and cardiovascular diseases. The enzyme aldose reductase (AR) has been implicated in the pathogenesis of some of these diseases and inhibitors of AR (ARIs) were effective in preventing some of the diabetic complications in animal models. However, clinical trials of these drugs were disappointing, casting doubt on the role of AR in these diseases. This review focuses on the recent studies using transgenic and gene knockout mice to analyze the role of AR in diabetic cataract and neuropathy. These studies clearly demonstrated that AR is crucial to the pathogenesis of these diseases, and that the mechanism leading to diabetic cataract may be different from that which causes diabetic neuropathy. A number of studies showed that there is a correlation between AR gene markers and susceptibility to develop complications among diabetic patients, suggesting that AR is also involved in the pathogenesis of diabetic complications in human. Together, these genetic studies strongly indicate that AR is an important target for the prevention of diabetic complications in human. This may provide impetus to develop more effective ARIs and to conduct better-designed clinical trials for ARIs in the prevention and treatment of these diseases.en_HK
dc.languageengen_HK
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmc/index.htmen_HK
dc.relation.ispartofCurrent Medicinal Chemistryen_HK
dc.subjectAldose reductaseen_HK
dc.subjectDiabetic complicationsen_HK
dc.subjectDNA polymorphismen_HK
dc.subjectGene knockouten_HK
dc.subjectTransgenicen_HK
dc.subject.meshAldehyde Reductase - genetics - metabolismen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCataract - enzymology - genetics - pathologyen_HK
dc.subject.meshDiabetes Complicationsen_HK
dc.subject.meshDiabetes Mellitus - enzymologyen_HK
dc.subject.meshDiabetic Nephropathies - enzymology - geneticsen_HK
dc.subject.meshDiabetic Neuropathies - embryology - genetics - pathologyen_HK
dc.subject.meshDiabetic Retinopathy - enzymology - genetics - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLens, Crystalline - enzymologyen_HK
dc.subject.meshOxidative Stressen_HK
dc.subject.meshPolymorphism, Genetic - geneticsen_HK
dc.subject.meshProtein Kinase C - metabolismen_HK
dc.titleGenetic analysis of aldose reductase in diabetic complicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0929-8673&volume=10&spage=1375&epage=87&date=2003&atitle=Genetic+analysis+of+aldose+reductase+in+diabetic+complicationsen_HK
dc.identifier.emailChung, SSM: smchung@hkucc.hku.hken_HK
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_HK
dc.identifier.authorityChung, SSM=rp00376en_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12871135-
dc.identifier.scopuseid_2-s2.0-0042371982en_HK
dc.identifier.hkuros79335en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042371982&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue15en_HK
dc.identifier.spage1375en_HK
dc.identifier.epage1387en_HK
dc.identifier.isiWOS:000184698000005-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChung, SSM=14120761600en_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK

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