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Article: Phosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development

TitlePhosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development
Authors
Peng, YJiang, BHYang, PHCao, ZShi, XLin, MCMHe, MLKung, HF
Issue Date2004
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal Of Biological Chemistry, 2004, v. 279 n. 27, p. 28509-28514 How to Cite?
DOI: http://dx.doi.org/10.1074/jbc.M402294200
AbstractPhosphatidylinositol 3-kinase (PI3K) has numerous cellular functions, including cell survival and proliferation. In this study, we demonstrated that the expression of the active form of PI3K induced dorsal differentiation and axis duplication and strongly induced the expression of neural markers. In contrast, the inhibition of PI3K activity by its dominant negative mutant induced the phenotype of losing posterior structures and the expression of ventral markers. Akt is an essential target of PI3K for neurogenesis. The expression of the active form of Akt induced axis duplication and increased the expression of neural markers. Inhibition of the Akt activity abolished the PI3K-induced double heads and axes. This signal transmits through its target, glycogen synthase kinase 3β, which is known to mediate Wnt signaling for Xenopus development. These results identify a new function of PI3K/Akt signaling in axis formation and neurogenesis during Xenopus embryonic development and provide a direct link between growth factor-mediated PI3K/Akt signaling and Wnt signaling during embryonic development.
Persistent Identifierhttp://hdl.handle.net/10722/88042
ISSN
0021-9258
2020 Impact Factor: 5.157
2023 SCImago Journal Rankings: 1.766
ISI Accession Number ID
WOS:000222265400086
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorPeng, Yen_HK
dc.contributor.authorJiang, BHen_HK
dc.contributor.authorYang, PHen_HK
dc.contributor.authorCao, Zen_HK
dc.contributor.authorShi, Xen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorHe, MLen_HK
dc.contributor.authorKung, HFen_HK
dc.date.accessioned2010-09-06T09:37:53Z-
dc.date.available2010-09-06T09:37:53Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Biological Chemistry, 2004, v. 279 n. 27, p. 28509-28514en_HK
dc.identifier.issn0021-9258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88042-
dc.description.abstractPhosphatidylinositol 3-kinase (PI3K) has numerous cellular functions, including cell survival and proliferation. In this study, we demonstrated that the expression of the active form of PI3K induced dorsal differentiation and axis duplication and strongly induced the expression of neural markers. In contrast, the inhibition of PI3K activity by its dominant negative mutant induced the phenotype of losing posterior structures and the expression of ventral markers. Akt is an essential target of PI3K for neurogenesis. The expression of the active form of Akt induced axis duplication and increased the expression of neural markers. Inhibition of the Akt activity abolished the PI3K-induced double heads and axes. This signal transmits through its target, glycogen synthase kinase 3β, which is known to mediate Wnt signaling for Xenopus development. These results identify a new function of PI3K/Akt signaling in axis formation and neurogenesis during Xenopus embryonic development and provide a direct link between growth factor-mediated PI3K/Akt signaling and Wnt signaling during embryonic development.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/en_HK
dc.relation.ispartofJournal of Biological Chemistryen_HK
dc.rightsJournal of Biological Chemistry. Copyright © American Society for Biochemistry and Molecular Biology, Inc.en_HK
dc.titlePhosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic developmenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9258&volume=279&issue=27&spage=28509&epage=14&date=2004&atitle=Phosphatidylinositol+3-kinase+signaling+is+involved+in+neurogenesis+during+Xenopus+embryonic+developmenten_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1074/jbc.M402294200en_HK
dc.identifier.pmid15123704-
dc.identifier.scopuseid_2-s2.0-3142579906en_HK
dc.identifier.hkuros91947en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3142579906&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume279en_HK
dc.identifier.issue27en_HK
dc.identifier.spage28509en_HK
dc.identifier.epage28514en_HK
dc.identifier.isiWOS:000222265400086-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPeng, Y=7403419265en_HK
dc.identifier.scopusauthoridJiang, BH=35264238500en_HK
dc.identifier.scopusauthoridYang, PH=24340289000en_HK
dc.identifier.scopusauthoridCao, Z=7402432345en_HK
dc.identifier.scopusauthoridShi, X=7402953332en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridHe, ML=35080389700en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.issnl0021-9258-

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