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Article: Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice

TitleNeuroprotective effects of tanshinones in transient focal cerebral ischemia in mice
Authors
KeywordsLabiatae
Middle cerebral artery occlusion
Salvia miltiorrhiza Bunge
Stroke
Traditional Chinese medicine
Issue Date2003
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
Citation
Phytomedicine, 2003, v. 10 n. 4, p. 286-291 How to Cite?
AbstractTanshinones are the major lipid soluble pharmacological constituents of Danshen, the dried roots of Salvia miltiorrhiza Bunge (Labiatae), a well known traditional Chinese medicine used for the treatment of cerebrovascular diseases including stroke. Potential neuroprotective effects of tanshinones IIA (TsIIA) and IIB (TsIIB) were examined in adult mice subjected to transient focal cerebral ischemia caused by middle cerebral artery occlusion (MCAo). Our results revealed that TsIIA (16 mg/kg) readily penetrated the blood brain barrier reaching a peak concentration of 0.41 nmol/g brain wet weight 60 minutes after intraperitoneal injection and decreased slowly over several hours. Twenty-four hours after middle cerebral artery occlusion, brain infarct volume was reduced by 30% and 37% following treatment with TsIIA and TsIIB, respectively. The reduction in brain infarct volume was accompanied by a significant decrease in the observed neurological deficit. Tanshinones or other structurally related compounds may have potential for further development as neuroprotective drugs.
Persistent Identifierhttp://hdl.handle.net/10722/88040
ISSN
2015 Impact Factor: 2.937
2015 SCImago Journal Rankings: 1.013
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, BYHen_HK
dc.contributor.authorLo, ACYen_HK
dc.contributor.authorSun, Xen_HK
dc.contributor.authorLuo, HWen_HK
dc.contributor.authorChung, SKen_HK
dc.contributor.authorSucher, NJen_HK
dc.date.accessioned2010-09-06T09:37:51Z-
dc.date.available2010-09-06T09:37:51Z-
dc.date.issued2003en_HK
dc.identifier.citationPhytomedicine, 2003, v. 10 n. 4, p. 286-291en_HK
dc.identifier.issn0944-7113en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88040-
dc.description.abstractTanshinones are the major lipid soluble pharmacological constituents of Danshen, the dried roots of Salvia miltiorrhiza Bunge (Labiatae), a well known traditional Chinese medicine used for the treatment of cerebrovascular diseases including stroke. Potential neuroprotective effects of tanshinones IIA (TsIIA) and IIB (TsIIB) were examined in adult mice subjected to transient focal cerebral ischemia caused by middle cerebral artery occlusion (MCAo). Our results revealed that TsIIA (16 mg/kg) readily penetrated the blood brain barrier reaching a peak concentration of 0.41 nmol/g brain wet weight 60 minutes after intraperitoneal injection and decreased slowly over several hours. Twenty-four hours after middle cerebral artery occlusion, brain infarct volume was reduced by 30% and 37% following treatment with TsIIA and TsIIB, respectively. The reduction in brain infarct volume was accompanied by a significant decrease in the observed neurological deficit. Tanshinones or other structurally related compounds may have potential for further development as neuroprotective drugs.en_HK
dc.languageengen_HK
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomeden_HK
dc.relation.ispartofPhytomedicineen_HK
dc.subjectLabiataeen_HK
dc.subjectMiddle cerebral artery occlusionen_HK
dc.subjectSalvia miltiorrhiza Bungeen_HK
dc.subjectStrokeen_HK
dc.subjectTraditional Chinese medicineen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnticoagulants - administration & dosage - pharmacokinetics - therapeutic useen_HK
dc.subject.meshBrain Ischemia - chemically induced - drug therapyen_HK
dc.subject.meshDiterpenes, Abietaneen_HK
dc.subject.meshDrugs, Chinese Herbal - administration & dosage - pharmacokinetics - therapeutic useen_HK
dc.subject.meshInjections, Intraperitonealen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshPhenanthrenes - administration & dosage - pharmacokinetics - therapeutic useen_HK
dc.subject.meshPhytotherapyen_HK
dc.subject.meshPlant Extracts - administration & dosage - pharmacokinetics - therapeutic useen_HK
dc.subject.meshPlant Rootsen_HK
dc.subject.meshSalvia miltiorrhizaen_HK
dc.titleNeuroprotective effects of tanshinones in transient focal cerebral ischemia in miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0944-7113&volume=10&issue=4&spage=286&epage=91&date=2003&atitle=Neuroprotective+effects+of+tanshinones+in+transient+focal+cerebral+ischemia+in+miceen_HK
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_HK
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_HK
dc.identifier.authorityLo, ACY=rp00425en_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1078/094471103322004776en_HK
dc.identifier.pmid12809358en_HK
dc.identifier.scopuseid_2-s2.0-0038249044en_HK
dc.identifier.hkuros79354en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038249044&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue4en_HK
dc.identifier.spage286en_HK
dc.identifier.epage291en_HK
dc.identifier.isiWOS:000183492800002-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLam, BYH=36747917700en_HK
dc.identifier.scopusauthoridLo, ACY=7102780640en_HK
dc.identifier.scopusauthoridSun, X=7405622532en_HK
dc.identifier.scopusauthoridLuo, HW=36982680600en_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK
dc.identifier.scopusauthoridSucher, NJ=7006507287en_HK

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