File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Aldose reductase (AC) n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitus

TitleAldose reductase (AC) n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitus
Authors
KeywordsAldose reductase
Diabetic microvascular complications
Genetic susceptibility
Polymorphism
Type 1 diabetes
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/diabres
Citation
Diabetes Research And Clinical Practice, 2001, v. 52 n. 1, p. 21-27 How to Cite?
Abstract
A case-control study to investigate whether the aldose reductase (AC) n dinucleotide polymorphism (termed 5′-ALR2 polymorphism) is useful as a genetic marker for risk of microvascular complications among Caucasians Type 1 diabetic patients in Australia is reported. This marker was amplified from patient genomic DNA and then fractionated in 5% formamide-urea gels. A total of nine alleles was observed with Z, Z-2 and Z+2 being the major alleles. The distribution of alleles was comparable in diabetic subjects with diabetes and microvascular complications, diabetes without complications and normal non-diabetic control subjects. Similarly, when the distribution of alleles was examined in the patients subcategorized according to the presence of diabetic nephropathy or diabetic neuropathy, no significant association was observed. While the size of the study makes it impossible to exclude a weak linkage, it is concluded that the 5′-ALR2 polymorphism is not useful as a genetic marker for susceptibility to diabetic microvascular complications in Caucasian Type 1 diabetic patients. Copyright © 2001 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/88035
ISSN
2013 Impact Factor: 2.536
2013 SCImago Journal Rankings: 1.219
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, DPKen_HK
dc.contributor.authorConn, Jen_HK
dc.contributor.authorChung, SSMen_HK
dc.contributor.authorG Larkins, Ren_HK
dc.date.accessioned2010-09-06T09:37:48Z-
dc.date.available2010-09-06T09:37:48Z-
dc.date.issued2001en_HK
dc.identifier.citationDiabetes Research And Clinical Practice, 2001, v. 52 n. 1, p. 21-27en_HK
dc.identifier.issn0168-8227en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88035-
dc.description.abstractA case-control study to investigate whether the aldose reductase (AC) n dinucleotide polymorphism (termed 5′-ALR2 polymorphism) is useful as a genetic marker for risk of microvascular complications among Caucasians Type 1 diabetic patients in Australia is reported. This marker was amplified from patient genomic DNA and then fractionated in 5% formamide-urea gels. A total of nine alleles was observed with Z, Z-2 and Z+2 being the major alleles. The distribution of alleles was comparable in diabetic subjects with diabetes and microvascular complications, diabetes without complications and normal non-diabetic control subjects. Similarly, when the distribution of alleles was examined in the patients subcategorized according to the presence of diabetic nephropathy or diabetic neuropathy, no significant association was observed. While the size of the study makes it impossible to exclude a weak linkage, it is concluded that the 5′-ALR2 polymorphism is not useful as a genetic marker for susceptibility to diabetic microvascular complications in Caucasian Type 1 diabetic patients. Copyright © 2001 Elsevier Science Ireland Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/diabresen_HK
dc.relation.ispartofDiabetes Research and Clinical Practiceen_HK
dc.rightsDiabetes Research and Clinical Practice. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAldose reductaseen_HK
dc.subjectDiabetic microvascular complicationsen_HK
dc.subjectGenetic susceptibilityen_HK
dc.subjectPolymorphismen_HK
dc.subjectType 1 diabetesen_HK
dc.titleAldose reductase (AC) n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0168-8227&volume=52&spage=21&epage=27&date=2001&atitle=Aldose+reductase+(AC)n+microsatellite+polymorphism+and+diabetic+microvascular+complications+in+Caucasian+Type+1+diabetes+mellitusen_HK
dc.identifier.emailChung, SSM: smchung@hkucc.hku.hken_HK
dc.identifier.authorityChung, SSM=rp00376en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0168-8227(00)00239-4en_HK
dc.identifier.pmid11182213en_HK
dc.identifier.scopuseid_2-s2.0-0035130657en_HK
dc.identifier.hkuros69248en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035130657&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue1en_HK
dc.identifier.spage21en_HK
dc.identifier.epage27en_HK
dc.identifier.isiWOS:000167395300003-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridNg, DPK=7201646516en_HK
dc.identifier.scopusauthoridConn, J=7101673511en_HK
dc.identifier.scopusauthoridChung, SSM=14120761600en_HK
dc.identifier.scopusauthoridG Larkins, R=7004338268en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats