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Article: Aldose reductase (AC) n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitus
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TitleAldose reductase (AC) n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitus
 
AuthorsNg, DPK3
Conn, J2
Chung, SSM1
G Larkins, R3
 
KeywordsAldose reductase
Diabetic microvascular complications
Genetic susceptibility
Polymorphism
Type 1 diabetes
 
Issue Date2001
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/diabres
 
CitationDiabetes Research And Clinical Practice, 2001, v. 52 n. 1, p. 21-27 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0168-8227(00)00239-4
 
AbstractA case-control study to investigate whether the aldose reductase (AC) n dinucleotide polymorphism (termed 5′-ALR2 polymorphism) is useful as a genetic marker for risk of microvascular complications among Caucasians Type 1 diabetic patients in Australia is reported. This marker was amplified from patient genomic DNA and then fractionated in 5% formamide-urea gels. A total of nine alleles was observed with Z, Z-2 and Z+2 being the major alleles. The distribution of alleles was comparable in diabetic subjects with diabetes and microvascular complications, diabetes without complications and normal non-diabetic control subjects. Similarly, when the distribution of alleles was examined in the patients subcategorized according to the presence of diabetic nephropathy or diabetic neuropathy, no significant association was observed. While the size of the study makes it impossible to exclude a weak linkage, it is concluded that the 5′-ALR2 polymorphism is not useful as a genetic marker for susceptibility to diabetic microvascular complications in Caucasian Type 1 diabetic patients. Copyright © 2001 Elsevier Science Ireland Ltd.
 
ISSN0168-8227
2013 Impact Factor: 2.536
2013 SCImago Journal Rankings: 1.219
 
DOIhttp://dx.doi.org/10.1016/S0168-8227(00)00239-4
 
ISI Accession Number IDWOS:000167395300003
 
ReferencesReferences in Scopus
 
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dc.contributor.authorNg, DPK
 
dc.contributor.authorConn, J
 
dc.contributor.authorChung, SSM
 
dc.contributor.authorG Larkins, R
 
dc.date.accessioned2010-09-06T09:37:48Z
 
dc.date.available2010-09-06T09:37:48Z
 
dc.date.issued2001
 
dc.description.abstractA case-control study to investigate whether the aldose reductase (AC) n dinucleotide polymorphism (termed 5′-ALR2 polymorphism) is useful as a genetic marker for risk of microvascular complications among Caucasians Type 1 diabetic patients in Australia is reported. This marker was amplified from patient genomic DNA and then fractionated in 5% formamide-urea gels. A total of nine alleles was observed with Z, Z-2 and Z+2 being the major alleles. The distribution of alleles was comparable in diabetic subjects with diabetes and microvascular complications, diabetes without complications and normal non-diabetic control subjects. Similarly, when the distribution of alleles was examined in the patients subcategorized according to the presence of diabetic nephropathy or diabetic neuropathy, no significant association was observed. While the size of the study makes it impossible to exclude a weak linkage, it is concluded that the 5′-ALR2 polymorphism is not useful as a genetic marker for susceptibility to diabetic microvascular complications in Caucasian Type 1 diabetic patients. Copyright © 2001 Elsevier Science Ireland Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationDiabetes Research And Clinical Practice, 2001, v. 52 n. 1, p. 21-27 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0168-8227(00)00239-4
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0168-8227(00)00239-4
 
dc.identifier.epage27
 
dc.identifier.hkuros69248
 
dc.identifier.isiWOS:000167395300003
 
dc.identifier.issn0168-8227
2013 Impact Factor: 2.536
2013 SCImago Journal Rankings: 1.219
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmid11182213
 
dc.identifier.scopuseid_2-s2.0-0035130657
 
dc.identifier.spage21
 
dc.identifier.urihttp://hdl.handle.net/10722/88035
 
dc.identifier.volume52
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/diabres
 
dc.publisher.placeIreland
 
dc.relation.ispartofDiabetes Research and Clinical Practice
 
dc.relation.referencesReferences in Scopus
 
dc.rightsDiabetes Research and Clinical Practice. Copyright © Elsevier Ireland Ltd.
 
dc.subjectAldose reductase
 
dc.subjectDiabetic microvascular complications
 
dc.subjectGenetic susceptibility
 
dc.subjectPolymorphism
 
dc.subjectType 1 diabetes
 
dc.titleAldose reductase (AC) n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitus
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Royal Melbourne Hospital
  3. University of Melbourne