Article: Aldose reductase (AC) n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitus

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TitleAldose reductase (AC) n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitus
AuthorsNg, DPK3
Conn, J2
Chung, SSM1
G Larkins, R3
KeywordsAldose reductase
Diabetic microvascular complications
Genetic susceptibility
Polymorphism
Type 1 diabetes
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/diabres
CitationDiabetes Research And Clinical Practice, 2001, v. 52 n. 1, p. 21-27 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0168-8227(00)00239-4
AbstractA case-control study to investigate whether the aldose reductase (AC) n dinucleotide polymorphism (termed 5′-ALR2 polymorphism) is useful as a genetic marker for risk of microvascular complications among Caucasians Type 1 diabetic patients in Australia is reported. This marker was amplified from patient genomic DNA and then fractionated in 5% formamide-urea gels. A total of nine alleles was observed with Z, Z-2 and Z+2 being the major alleles. The distribution of alleles was comparable in diabetic subjects with diabetes and microvascular complications, diabetes without complications and normal non-diabetic control subjects. Similarly, when the distribution of alleles was examined in the patients subcategorized according to the presence of diabetic nephropathy or diabetic neuropathy, no significant association was observed. While the size of the study makes it impossible to exclude a weak linkage, it is concluded that the 5′-ALR2 polymorphism is not useful as a genetic marker for susceptibility to diabetic microvascular complications in Caucasian Type 1 diabetic patients. Copyright © 2001 Elsevier Science Ireland Ltd.
ISSN0168-8227
2011 Impact Factor: 2.754
2011 SCImago Journal Rankings: 0.178
DOIhttp://dx.doi.org/10.1016/S0168-8227(00)00239-4
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorNg, DPK
dc.contributor.authorConn, J
dc.contributor.authorChung, SSM
dc.contributor.authorG Larkins, R
dc.date.accessioned2010-09-06T09:37:48Z
dc.date.available2010-09-06T09:37:48Z
dc.date.issued2001
dc.description.abstractA case-control study to investigate whether the aldose reductase (AC) n dinucleotide polymorphism (termed 5′-ALR2 polymorphism) is useful as a genetic marker for risk of microvascular complications among Caucasians Type 1 diabetic patients in Australia is reported. This marker was amplified from patient genomic DNA and then fractionated in 5% formamide-urea gels. A total of nine alleles was observed with Z, Z-2 and Z+2 being the major alleles. The distribution of alleles was comparable in diabetic subjects with diabetes and microvascular complications, diabetes without complications and normal non-diabetic control subjects. Similarly, when the distribution of alleles was examined in the patients subcategorized according to the presence of diabetic nephropathy or diabetic neuropathy, no significant association was observed. While the size of the study makes it impossible to exclude a weak linkage, it is concluded that the 5′-ALR2 polymorphism is not useful as a genetic marker for susceptibility to diabetic microvascular complications in Caucasian Type 1 diabetic patients. Copyright © 2001 Elsevier Science Ireland Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDiabetes Research And Clinical Practice, 2001, v. 52 n. 1, p. 21-27 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0168-8227(00)00239-4
dc.identifier.doihttp://dx.doi.org/10.1016/S0168-8227(00)00239-4
dc.identifier.epage27
dc.identifier.hkuros69248
dc.identifier.isiWOS:000167395300003
dc.identifier.issn0168-8227
2011 Impact Factor: 2.754
2011 SCImago Journal Rankings: 0.178
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid11182213
dc.identifier.scopuseid_2-s2.0-0035130657
dc.identifier.spage21
dc.identifier.urihttp://hdl.handle.net/10722/88035
dc.identifier.volume52
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/diabres
dc.publisher.placeIreland
dc.relation.ispartofDiabetes Research and Clinical Practice
dc.relation.referencesReferences in Scopus
dc.rightsDiabetes Research and Clinical Practice. Copyright © Elsevier Ireland Ltd.
dc.subjectAldose reductase
dc.subjectDiabetic microvascular complications
dc.subjectGenetic susceptibility
dc.subjectPolymorphism
dc.subjectType 1 diabetes
dc.titleAldose reductase (AC) n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitus
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Royal Melbourne Hospital
  3. University of Melbourne