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Article: Tissue-specific expression of two aldose reductase-like genes in mice: Abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland

TitleTissue-specific expression of two aldose reductase-like genes in mice: Abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal gland
Authors
Issue Date1995
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.org
Citation
Biochemical Journal, 1995, v. 312 n. 2, p. 609-615 How to Cite?
AbstractAldose reductase (AR), the first enzyme in the polyol pathway, has been implicated in the pathogenesis of diabetic complications, although its physiological role is unclear. In mice, besides AR, two AR-like proteins, mouse vas deferens protein (MVDP) and fibroblast growth factor-regulated protein (FR-1), have been reported recently. Tissue-specific expression of these two genes was examined using the RNase protection assay method. Contrary to previous reports, MVDP was detected in a variety of tissues besides the vas deferens. High levels of MVDP mRNA were found in the adrenal glands, and low levels of expression were detected in eye, intestine, seminal vesicle, kidney, liver, testis and lung. The major gene expression pattern for FR-1 was slightly different from that of MVDP, with the highest levels of mRNA detected in testis, heart, adrenal gland, and ovary; less was found in the lung and it was barely detectable in eye, intestine, liver and seminal vesicle tissue. Mouse embryos, as early as 10.5 days post coitum, expressed both genes, although the levels of expression were different. Human AR mRNA was found in human vas deferens, although not at the high level found in mice. The localization of both MVDP and FR-1 transcripts in the adrenal cortex by in situ hybridization led to the speculation that these two AR-like proteins could be related to hormone production.
Persistent Identifierhttp://hdl.handle.net/10722/88020
ISSN
2015 Impact Factor: 3.562
2015 SCImago Journal Rankings: 2.582
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, ETen_HK
dc.contributor.authorCao, Den_HK
dc.contributor.authorLin, Cen_HK
dc.contributor.authorChung, SKen_HK
dc.contributor.authorChung, SSen_HK
dc.date.accessioned2010-09-06T09:37:36Z-
dc.date.available2010-09-06T09:37:36Z-
dc.date.issued1995en_HK
dc.identifier.citationBiochemical Journal, 1995, v. 312 n. 2, p. 609-615en_HK
dc.identifier.issn0264-6021en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88020-
dc.description.abstractAldose reductase (AR), the first enzyme in the polyol pathway, has been implicated in the pathogenesis of diabetic complications, although its physiological role is unclear. In mice, besides AR, two AR-like proteins, mouse vas deferens protein (MVDP) and fibroblast growth factor-regulated protein (FR-1), have been reported recently. Tissue-specific expression of these two genes was examined using the RNase protection assay method. Contrary to previous reports, MVDP was detected in a variety of tissues besides the vas deferens. High levels of MVDP mRNA were found in the adrenal glands, and low levels of expression were detected in eye, intestine, seminal vesicle, kidney, liver, testis and lung. The major gene expression pattern for FR-1 was slightly different from that of MVDP, with the highest levels of mRNA detected in testis, heart, adrenal gland, and ovary; less was found in the lung and it was barely detectable in eye, intestine, liver and seminal vesicle tissue. Mouse embryos, as early as 10.5 days post coitum, expressed both genes, although the levels of expression were different. Human AR mRNA was found in human vas deferens, although not at the high level found in mice. The localization of both MVDP and FR-1 transcripts in the adrenal cortex by in situ hybridization led to the speculation that these two AR-like proteins could be related to hormone production.en_HK
dc.languageengen_HK
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.orgen_HK
dc.relation.ispartofBiochemical Journalen_HK
dc.subject.meshAdrenal Glands - enzymologyen_HK
dc.subject.meshAldehyde Reductase - biosynthesis - geneticsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBase Sequenceen_HK
dc.subject.meshCloning, Molecularen_HK
dc.subject.meshEmbryo, Mammalianen_HK
dc.subject.meshExonsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFibroblast Growth Factors - pharmacologyen_HK
dc.subject.meshGene Expression Regulation, Enzymologic - drug effectsen_HK
dc.subject.meshGenomic Libraryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMice - geneticsen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshOrgan Specificityen_HK
dc.subject.meshOvary - enzymologyen_HK
dc.subject.meshRNA, Messenger - analysis - biosynthesisen_HK
dc.subject.meshRecombinant Proteins - biosynthesisen_HK
dc.subject.meshSequence Homology, Nucleic Aciden_HK
dc.subject.meshSex Characteristicsen_HK
dc.subject.meshVas Deferens - enzymologyen_HK
dc.titleTissue-specific expression of two aldose reductase-like genes in mice: Abundant expression of mouse vas deferens protein and fibroblast growth factor-regulated protein in the adrenal glanden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0264-6021&volume=312&spage=609&epage=615&date=1995&atitle=Tissue-specific+expression+of+two+aldose+reductase-like+genes+in+mice:+abundant+expression+of+mouse+vas+deferens+protein+and+fibroblast+growth+factor-regulated+protein+in+the+adrenal+glanden_HK
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_HK
dc.identifier.emailChung, SS: smchung@hkucc.hku.hken_HK
dc.identifier.authorityChung, SK=rp00381en_HK
dc.identifier.authorityChung, SS=rp00376en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid8526877-
dc.identifier.pmcidPMC1136305-
dc.identifier.scopuseid_2-s2.0-0029610824en_HK
dc.identifier.hkuros13594en_HK
dc.identifier.volume312en_HK
dc.identifier.issue2en_HK
dc.identifier.spage609en_HK
dc.identifier.epage615en_HK
dc.identifier.isiWOS:A1995TJ26800039-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, ET=35302963200en_HK
dc.identifier.scopusauthoridCao, D=7202125033en_HK
dc.identifier.scopusauthoridLin, C=15035068300en_HK
dc.identifier.scopusauthoridChung, SK=7404292976en_HK
dc.identifier.scopusauthoridChung, SS=14120761600en_HK

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