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Article: Molecular basis for differing antineurogenic effects of GATA-1a and GATA-1b in Xenopus

TitleMolecular basis for differing antineurogenic effects of GATA-1a and GATA-1b in Xenopus
Authors
KeywordsChimeras
Erythropoiesis
Neurogenesis
Transcription factor
Untranslated regions
Issue Date2000
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2000, v. 273 n. 2, p. 614-620 How to Cite?
AbstractThe erythroid transcription factor GATA-1 in Xenopus has been cloned as a pair of presumably duplicated genes designated as xGATA-1a and xGATA-1b. Although both xGATA-1a and xGATA-1b are able to stimulate erythropoiesis, only xGATA-1b is capable of inhibiting neurogenesis in Xenopus embryos. Chimeras of these two genes were constructed by permuting coding and untranslated regions (UTR) on both ends of these two xGATA-1, and their neurogenesis-inhibitory effects were studied. These results reveal that (1) sequence variations between the coding regions alone do not account for the neurogenesis effect; (2) 3' UTR of xGATA-1a causes the loss of the neurogenesis inhibition of xGATA-1b; (3) 3' UTR of xGATA-1b is essential to inhibit neurogenesis. In addition, the presence of either UTR does not affect the stability of the mRNA in vitro. These observations suggest the influence of 3' UTR in xGATA-1 on the inhibition of neurogenesis. (C) 2000 Academic Press.
Persistent Identifierhttp://hdl.handle.net/10722/88016
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, HDen_HK
dc.contributor.authorHuang, YKen_HK
dc.contributor.authorAult, Ken_HK
dc.contributor.authorWong, GWen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorChen, HCen_HK
dc.contributor.authorKung, HFen_HK
dc.date.accessioned2010-09-06T09:37:33Z-
dc.date.available2010-09-06T09:37:33Z-
dc.date.issued2000en_HK
dc.identifier.citationBiochemical And Biophysical Research Communications, 2000, v. 273 n. 2, p. 614-620en_HK
dc.identifier.issn0006-291Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/88016-
dc.description.abstractThe erythroid transcription factor GATA-1 in Xenopus has been cloned as a pair of presumably duplicated genes designated as xGATA-1a and xGATA-1b. Although both xGATA-1a and xGATA-1b are able to stimulate erythropoiesis, only xGATA-1b is capable of inhibiting neurogenesis in Xenopus embryos. Chimeras of these two genes were constructed by permuting coding and untranslated regions (UTR) on both ends of these two xGATA-1, and their neurogenesis-inhibitory effects were studied. These results reveal that (1) sequence variations between the coding regions alone do not account for the neurogenesis effect; (2) 3' UTR of xGATA-1a causes the loss of the neurogenesis inhibition of xGATA-1b; (3) 3' UTR of xGATA-1b is essential to inhibit neurogenesis. In addition, the presence of either UTR does not affect the stability of the mRNA in vitro. These observations suggest the influence of 3' UTR in xGATA-1 on the inhibition of neurogenesis. (C) 2000 Academic Press.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_HK
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_HK
dc.subjectChimerasen_HK
dc.subjectErythropoiesisen_HK
dc.subjectNeurogenesisen_HK
dc.subjectTranscription factoren_HK
dc.subjectUntranslated regionsen_HK
dc.titleMolecular basis for differing antineurogenic effects of GATA-1a and GATA-1b in Xenopusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-291X&volume=273&issue=2&spage=614&epage=620&date=2000&atitle=Molecular+basis+for+differing+antineurogenic+effects+of+GATA-1a+and+Gata-1b+in+Xenopusen_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/bbrc.2000.2988en_HK
dc.identifier.pmid10873654-
dc.identifier.scopuseid_2-s2.0-0033877029en_HK
dc.identifier.hkuros51924en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033877029&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume273en_HK
dc.identifier.issue2en_HK
dc.identifier.spage614en_HK
dc.identifier.epage620en_HK
dc.identifier.isiWOS:000088128300039-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, HD=7501625999en_HK
dc.identifier.scopusauthoridHuang, YK=37862635500en_HK
dc.identifier.scopusauthoridAult, K=7005241219en_HK
dc.identifier.scopusauthoridWong, GW=36769467400en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridChen, HC=7501614737en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK

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