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Article: Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening
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TitleOverweight in children is associated with arterial endothelial dysfunction and intima-media thickening
 
AuthorsWoo, KS2
Chook, P2
Yu, CW2
Sung, RYT2
Qiao, M2
Leung, SSF2
Lam, CWK2
Metreweli, C2
Celermajer, DS1
 
KeywordsAtherosclerosis
Body mass index
Carotid intima-media thickening
Endothelium
Overweight in children
 
Issue Date2004
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/
 
CitationInternational Journal Of Obesity, 2004, v. 28 n. 7, p. 852-857 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.ijo.0802539
 
AbstractOBJECTIVE: We sought to study arterial endothelial function and carotid intima-media thickness (IMT), both early markers of atherosclerosis, in overweight compared to normal children. DESIGN: Case-control comparison. SUBJECTS: A total of 36 asymptomatic overweight children (body mass index (BMI) > 23; mean 25 ± 3) aged 9-12 y and 36 age- and gender-matched nonobese healthy children (BMI < 21) from a school community. MEASUREMENTS: The key parameters were: BMI, arterial endothelial function (ultrasound-derived endothelium-dependent dilation) and carotid artery IMT. The secondary parameters measured included body fat content, waist-hip ratio (WHR), blood pressures, blood lipids, insulin and glucose. RESULTS: The two groups were well matched for blood pressures, cholesterol and glucose levels, but BMI (P<0.0001), body fat (P = 0.001), WHR (P < 0.05), fasting blood insulin (P = 0.001) and triglyceride levels (P < 0.05) were higher in obese children. Overweight was associated with impaired arterial endothelial function (6.6 ± 2.3 vs 9.7 ± 3.0%, P < 0.0001) and increased carotid IMT (0.49 ± 0.04 mm vs 0.45 ± 0.04 mm, P = 0.006). The degree of endothelial dysfunction correlated with BMI (P < 0.003) on multivariate analysis. CONCLUSION: Obesity, even of mild-to-moderate degree, is independently associated with abnormal arterial function and structure in otherwise healthy young children.
 
ISSN0307-0565
2012 Impact Factor: 5.221
2012 SCImago Journal Rankings: 1.904
 
DOIhttp://dx.doi.org/10.1038/sj.ijo.0802539
 
ISI Accession Number IDWOS:000222136500004
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWoo, KS
 
dc.contributor.authorChook, P
 
dc.contributor.authorYu, CW
 
dc.contributor.authorSung, RYT
 
dc.contributor.authorQiao, M
 
dc.contributor.authorLeung, SSF
 
dc.contributor.authorLam, CWK
 
dc.contributor.authorMetreweli, C
 
dc.contributor.authorCelermajer, DS
 
dc.date.accessioned2010-09-06T09:36:10Z
 
dc.date.available2010-09-06T09:36:10Z
 
dc.date.issued2004
 
dc.description.abstractOBJECTIVE: We sought to study arterial endothelial function and carotid intima-media thickness (IMT), both early markers of atherosclerosis, in overweight compared to normal children. DESIGN: Case-control comparison. SUBJECTS: A total of 36 asymptomatic overweight children (body mass index (BMI) > 23; mean 25 ± 3) aged 9-12 y and 36 age- and gender-matched nonobese healthy children (BMI < 21) from a school community. MEASUREMENTS: The key parameters were: BMI, arterial endothelial function (ultrasound-derived endothelium-dependent dilation) and carotid artery IMT. The secondary parameters measured included body fat content, waist-hip ratio (WHR), blood pressures, blood lipids, insulin and glucose. RESULTS: The two groups were well matched for blood pressures, cholesterol and glucose levels, but BMI (P<0.0001), body fat (P = 0.001), WHR (P < 0.05), fasting blood insulin (P = 0.001) and triglyceride levels (P < 0.05) were higher in obese children. Overweight was associated with impaired arterial endothelial function (6.6 ± 2.3 vs 9.7 ± 3.0%, P < 0.0001) and increased carotid IMT (0.49 ± 0.04 mm vs 0.45 ± 0.04 mm, P = 0.006). The degree of endothelial dysfunction correlated with BMI (P < 0.003) on multivariate analysis. CONCLUSION: Obesity, even of mild-to-moderate degree, is independently associated with abnormal arterial function and structure in otherwise healthy young children.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Obesity, 2004, v. 28 n. 7, p. 852-857 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.ijo.0802539
 
dc.identifier.doihttp://dx.doi.org/10.1038/sj.ijo.0802539
 
dc.identifier.epage857
 
dc.identifier.hkuros100143
 
dc.identifier.isiWOS:000222136500004
 
dc.identifier.issn0307-0565
2012 Impact Factor: 5.221
2012 SCImago Journal Rankings: 1.904
 
dc.identifier.issue7
 
dc.identifier.pmid15170465
 
dc.identifier.scopuseid_2-s2.0-3442880238
 
dc.identifier.spage852
 
dc.identifier.urihttp://hdl.handle.net/10722/87922
 
dc.identifier.volume28
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofInternational Journal of Obesity
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAtherosclerosis
 
dc.subjectBody mass index
 
dc.subjectCarotid intima-media thickening
 
dc.subjectEndothelium
 
dc.subjectOverweight in children
 
dc.titleOverweight in children is associated with arterial endothelial dysfunction and intima-media thickening
 
dc.typeArticle
 
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<item><contributor.author>Woo, KS</contributor.author>
<contributor.author>Chook, P</contributor.author>
<contributor.author>Yu, CW</contributor.author>
<contributor.author>Sung, RYT</contributor.author>
<contributor.author>Qiao, M</contributor.author>
<contributor.author>Leung, SSF</contributor.author>
<contributor.author>Lam, CWK</contributor.author>
<contributor.author>Metreweli, C</contributor.author>
<contributor.author>Celermajer, DS</contributor.author>
<date.accessioned>2010-09-06T09:36:10Z</date.accessioned>
<date.available>2010-09-06T09:36:10Z</date.available>
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<description.abstract>OBJECTIVE: We sought to study arterial endothelial function and carotid intima-media thickness (IMT), both early markers of atherosclerosis, in overweight compared to normal children. DESIGN: Case-control comparison. SUBJECTS: A total of 36 asymptomatic overweight children (body mass index (BMI) &gt; 23; mean 25 &#177; 3) aged 9-12 y and 36 age- and gender-matched nonobese healthy children (BMI &lt; 21) from a school community. MEASUREMENTS: The key parameters were: BMI, arterial endothelial function (ultrasound-derived endothelium-dependent dilation) and carotid artery IMT. The secondary parameters measured included body fat content, waist-hip ratio (WHR), blood pressures, blood lipids, insulin and glucose. RESULTS: The two groups were well matched for blood pressures, cholesterol and glucose levels, but BMI (P&lt;0.0001), body fat (P = 0.001), WHR (P &lt; 0.05), fasting blood insulin (P = 0.001) and triglyceride levels (P &lt; 0.05) were higher in obese children. Overweight was associated with impaired arterial endothelial function (6.6 &#177; 2.3 vs 9.7 &#177; 3.0%, P &lt; 0.0001) and increased carotid IMT (0.49 &#177; 0.04 mm vs 0.45 &#177; 0.04 mm, P = 0.006). The degree of endothelial dysfunction correlated with BMI (P &lt; 0.003) on multivariate analysis. CONCLUSION: Obesity, even of mild-to-moderate degree, is independently associated with abnormal arterial function and structure in otherwise healthy young children.</description.abstract>
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<subject>Atherosclerosis</subject>
<subject>Body mass index</subject>
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Author Affiliations
  1. University of Sydney
  2. Prince of Wales Hospital Hong Kong