Article: Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening

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TitleOverweight in children is associated with arterial endothelial dysfunction and intima-media thickening
AuthorsWoo, KS2
Chook, P2
Yu, CW2
Sung, RYT2
Qiao, M2
Leung, SSF2
Lam, CWK2
Metreweli, C2
Celermajer, DS1
KeywordsAtherosclerosis
Body mass index
Carotid intima-media thickening
Endothelium
Overweight in children
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/
CitationInternational Journal Of Obesity, 2004, v. 28 n. 7, p. 852-857 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.ijo.0802539
AbstractOBJECTIVE: We sought to study arterial endothelial function and carotid intima-media thickness (IMT), both early markers of atherosclerosis, in overweight compared to normal children. DESIGN: Case-control comparison. SUBJECTS: A total of 36 asymptomatic overweight children (body mass index (BMI) > 23; mean 25 ± 3) aged 9-12 y and 36 age- and gender-matched nonobese healthy children (BMI < 21) from a school community. MEASUREMENTS: The key parameters were: BMI, arterial endothelial function (ultrasound-derived endothelium-dependent dilation) and carotid artery IMT. The secondary parameters measured included body fat content, waist-hip ratio (WHR), blood pressures, blood lipids, insulin and glucose. RESULTS: The two groups were well matched for blood pressures, cholesterol and glucose levels, but BMI (P<0.0001), body fat (P = 0.001), WHR (P < 0.05), fasting blood insulin (P = 0.001) and triglyceride levels (P < 0.05) were higher in obese children. Overweight was associated with impaired arterial endothelial function (6.6 ± 2.3 vs 9.7 ± 3.0%, P < 0.0001) and increased carotid IMT (0.49 ± 0.04 mm vs 0.45 ± 0.04 mm, P = 0.006). The degree of endothelial dysfunction correlated with BMI (P < 0.003) on multivariate analysis. CONCLUSION: Obesity, even of mild-to-moderate degree, is independently associated with abnormal arterial function and structure in otherwise healthy young children.
ISSN0307-0565
2011 Impact Factor: 4.691
2011 SCImago Journal Rankings: 0.429
DOIhttp://dx.doi.org/10.1038/sj.ijo.0802539
ISI Accession Number IDWOS:000222136500004
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWoo, KS
dc.contributor.authorChook, P
dc.contributor.authorYu, CW
dc.contributor.authorSung, RYT
dc.contributor.authorQiao, M
dc.contributor.authorLeung, SSF
dc.contributor.authorLam, CWK
dc.contributor.authorMetreweli, C
dc.contributor.authorCelermajer, DS
dc.date.accessioned2010-09-06T09:36:10Z
dc.date.available2010-09-06T09:36:10Z
dc.date.issued2004
dc.description.abstractOBJECTIVE: We sought to study arterial endothelial function and carotid intima-media thickness (IMT), both early markers of atherosclerosis, in overweight compared to normal children. DESIGN: Case-control comparison. SUBJECTS: A total of 36 asymptomatic overweight children (body mass index (BMI) > 23; mean 25 ± 3) aged 9-12 y and 36 age- and gender-matched nonobese healthy children (BMI < 21) from a school community. MEASUREMENTS: The key parameters were: BMI, arterial endothelial function (ultrasound-derived endothelium-dependent dilation) and carotid artery IMT. The secondary parameters measured included body fat content, waist-hip ratio (WHR), blood pressures, blood lipids, insulin and glucose. RESULTS: The two groups were well matched for blood pressures, cholesterol and glucose levels, but BMI (P<0.0001), body fat (P = 0.001), WHR (P < 0.05), fasting blood insulin (P = 0.001) and triglyceride levels (P < 0.05) were higher in obese children. Overweight was associated with impaired arterial endothelial function (6.6 ± 2.3 vs 9.7 ± 3.0%, P < 0.0001) and increased carotid IMT (0.49 ± 0.04 mm vs 0.45 ± 0.04 mm, P = 0.006). The degree of endothelial dysfunction correlated with BMI (P < 0.003) on multivariate analysis. CONCLUSION: Obesity, even of mild-to-moderate degree, is independently associated with abnormal arterial function and structure in otherwise healthy young children.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Obesity, 2004, v. 28 n. 7, p. 852-857 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.ijo.0802539
dc.identifier.doihttp://dx.doi.org/10.1038/sj.ijo.0802539
dc.identifier.epage857
dc.identifier.hkuros100143
dc.identifier.isiWOS:000222136500004
dc.identifier.issn0307-0565
2011 Impact Factor: 4.691
2011 SCImago Journal Rankings: 0.429
dc.identifier.issue7
dc.identifier.pmid15170465
dc.identifier.scopuseid_2-s2.0-3442880238
dc.identifier.spage852
dc.identifier.urihttp://hdl.handle.net/10722/87922
dc.identifier.volume28
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofInternational Journal of Obesity
dc.relation.referencesReferences in Scopus
dc.subjectAtherosclerosis
dc.subjectBody mass index
dc.subjectCarotid intima-media thickening
dc.subjectEndothelium
dc.subjectOverweight in children
dc.titleOverweight in children is associated with arterial endothelial dysfunction and intima-media thickening
dc.typeArticle
Author Affiliations
  1. University of Sydney
  2. Prince of Wales Hospital Hong Kong