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Article: Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening

TitleOverweight in children is associated with arterial endothelial dysfunction and intima-media thickening
Authors
KeywordsAtherosclerosis
Body mass index
Carotid intima-media thickening
Endothelium
Overweight in children
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/
Citation
International Journal Of Obesity, 2004, v. 28 n. 7, p. 852-857 How to Cite?
Abstract
OBJECTIVE: We sought to study arterial endothelial function and carotid intima-media thickness (IMT), both early markers of atherosclerosis, in overweight compared to normal children. DESIGN: Case-control comparison. SUBJECTS: A total of 36 asymptomatic overweight children (body mass index (BMI) > 23; mean 25 ± 3) aged 9-12 y and 36 age- and gender-matched nonobese healthy children (BMI < 21) from a school community. MEASUREMENTS: The key parameters were: BMI, arterial endothelial function (ultrasound-derived endothelium-dependent dilation) and carotid artery IMT. The secondary parameters measured included body fat content, waist-hip ratio (WHR), blood pressures, blood lipids, insulin and glucose. RESULTS: The two groups were well matched for blood pressures, cholesterol and glucose levels, but BMI (P<0.0001), body fat (P = 0.001), WHR (P < 0.05), fasting blood insulin (P = 0.001) and triglyceride levels (P < 0.05) were higher in obese children. Overweight was associated with impaired arterial endothelial function (6.6 ± 2.3 vs 9.7 ± 3.0%, P < 0.0001) and increased carotid IMT (0.49 ± 0.04 mm vs 0.45 ± 0.04 mm, P = 0.006). The degree of endothelial dysfunction correlated with BMI (P < 0.003) on multivariate analysis. CONCLUSION: Obesity, even of mild-to-moderate degree, is independently associated with abnormal arterial function and structure in otherwise healthy young children.
Persistent Identifierhttp://hdl.handle.net/10722/87922
ISSN
2013 Impact Factor: 5.386
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWoo, KSen_HK
dc.contributor.authorChook, Pen_HK
dc.contributor.authorYu, CWen_HK
dc.contributor.authorSung, RYTen_HK
dc.contributor.authorQiao, Men_HK
dc.contributor.authorLeung, SSFen_HK
dc.contributor.authorLam, CWKen_HK
dc.contributor.authorMetreweli, Cen_HK
dc.contributor.authorCelermajer, DSen_HK
dc.date.accessioned2010-09-06T09:36:10Z-
dc.date.available2010-09-06T09:36:10Z-
dc.date.issued2004en_HK
dc.identifier.citationInternational Journal Of Obesity, 2004, v. 28 n. 7, p. 852-857en_HK
dc.identifier.issn0307-0565en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87922-
dc.description.abstractOBJECTIVE: We sought to study arterial endothelial function and carotid intima-media thickness (IMT), both early markers of atherosclerosis, in overweight compared to normal children. DESIGN: Case-control comparison. SUBJECTS: A total of 36 asymptomatic overweight children (body mass index (BMI) > 23; mean 25 ± 3) aged 9-12 y and 36 age- and gender-matched nonobese healthy children (BMI < 21) from a school community. MEASUREMENTS: The key parameters were: BMI, arterial endothelial function (ultrasound-derived endothelium-dependent dilation) and carotid artery IMT. The secondary parameters measured included body fat content, waist-hip ratio (WHR), blood pressures, blood lipids, insulin and glucose. RESULTS: The two groups were well matched for blood pressures, cholesterol and glucose levels, but BMI (P<0.0001), body fat (P = 0.001), WHR (P < 0.05), fasting blood insulin (P = 0.001) and triglyceride levels (P < 0.05) were higher in obese children. Overweight was associated with impaired arterial endothelial function (6.6 ± 2.3 vs 9.7 ± 3.0%, P < 0.0001) and increased carotid IMT (0.49 ± 0.04 mm vs 0.45 ± 0.04 mm, P = 0.006). The degree of endothelial dysfunction correlated with BMI (P < 0.003) on multivariate analysis. CONCLUSION: Obesity, even of mild-to-moderate degree, is independently associated with abnormal arterial function and structure in otherwise healthy young children.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ijo/en_HK
dc.relation.ispartofInternational Journal of Obesityen_HK
dc.subjectAtherosclerosisen_HK
dc.subjectBody mass indexen_HK
dc.subjectCarotid intima-media thickeningen_HK
dc.subjectEndotheliumen_HK
dc.subjectOverweight in childrenen_HK
dc.titleOverweight in children is associated with arterial endothelial dysfunction and intima-media thickeningen_HK
dc.typeArticleen_HK
dc.identifier.emailYu, CW: yucw@hkucc.hku.hken_HK
dc.identifier.authorityYu, CW=rp00982en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/sj.ijo.0802539en_HK
dc.identifier.pmid15170465en_HK
dc.identifier.scopuseid_2-s2.0-3442880238en_HK
dc.identifier.hkuros100143en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3442880238&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue7en_HK
dc.identifier.spage852en_HK
dc.identifier.epage857en_HK
dc.identifier.isiWOS:000222136500004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWoo, KS=7202574149en_HK
dc.identifier.scopusauthoridChook, P=6603266983en_HK
dc.identifier.scopusauthoridYu, CW=35235958400en_HK
dc.identifier.scopusauthoridSung, RYT=7101684314en_HK
dc.identifier.scopusauthoridQiao, M=7006316387en_HK
dc.identifier.scopusauthoridLeung, SSF=7202044842en_HK
dc.identifier.scopusauthoridLam, CWK=7402527629en_HK
dc.identifier.scopusauthoridMetreweli, C=55397062200en_HK
dc.identifier.scopusauthoridCelermajer, DS=7005533405en_HK

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