File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effects of Diet and Exercise on Obesity-Related Vascular Dysfunction in Children

TitleEffects of Diet and Exercise on Obesity-Related Vascular Dysfunction in Children
Authors
KeywordsAtherosclerosis
Endothelium
Exercise
Lifestyle
Obesity
Issue Date2004
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.org
Citation
Circulation, 2004, v. 109 n. 16, p. 1981-1986 How to Cite?
AbstractBackground-The prevalence of obesity in both adults and children is increasing rapidly. Obesity in children is independently associated with arterial endothelial dysfunction and wall thickening, key early events in atherogenesis that precede plaque formation. Methods and Results-To evaluate the reversibility of obesity-related arterial dysfunction and carotid intima-media thickening by dietary and/or exercise intervention programs, 82 overweight children (body mass index, 25 ± 3), 9 to 12 years of age, were randomly assigned to dietary modification only or diet plus a supervised structured exercise program for 6 weeks and subsequently for 1 year. The prospectively defined primary end points were ultrasound-derived arterial endothelial function (endothelium-dependent dilation) of the brachial artery and intima-media thickness of common carotid artery. At 6 weeks, both interventions were associated with decreased waist-hip ratio (P<0.02) and cholesterol level (P<0.05) as well as improved arterial endothelial function. Diet and exercise together were associated with a significantly greater improvement in endothelial function than diet alone (P=0.01). At 1 year, there was significantly less thickening of the carotid wall (P<0.001) as well as persistent improvements in body fat content and lipid profiles in the group continuing an exercise program. Vascular function was significantly better in those children continuing exercise (n=22) compared with children who withdrew from the exercise program (n= 19) (P<0.05). Conclusions-Obesity-related vascular dysfunction in otherwise healthy young children is partially reversible with diet alone or particularly diet combined with exercise training at 6 weeks, with sustained improvements at 1 year in those persisting with diet plus regular exercise.
Persistent Identifierhttp://hdl.handle.net/10722/87919
ISSN
2015 Impact Factor: 17.047
2015 SCImago Journal Rankings: 7.853
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWoo, KSen_HK
dc.contributor.authorChook, Pen_HK
dc.contributor.authorYu, CWen_HK
dc.contributor.authorSung, RYTen_HK
dc.contributor.authorQiao, Men_HK
dc.contributor.authorLeung, SSFen_HK
dc.contributor.authorLam, CWKen_HK
dc.contributor.authorMetreweli, Cen_HK
dc.contributor.authorCelermajer, DSen_HK
dc.date.accessioned2010-09-06T09:36:08Z-
dc.date.available2010-09-06T09:36:08Z-
dc.date.issued2004en_HK
dc.identifier.citationCirculation, 2004, v. 109 n. 16, p. 1981-1986en_HK
dc.identifier.issn0009-7322en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87919-
dc.description.abstractBackground-The prevalence of obesity in both adults and children is increasing rapidly. Obesity in children is independently associated with arterial endothelial dysfunction and wall thickening, key early events in atherogenesis that precede plaque formation. Methods and Results-To evaluate the reversibility of obesity-related arterial dysfunction and carotid intima-media thickening by dietary and/or exercise intervention programs, 82 overweight children (body mass index, 25 ± 3), 9 to 12 years of age, were randomly assigned to dietary modification only or diet plus a supervised structured exercise program for 6 weeks and subsequently for 1 year. The prospectively defined primary end points were ultrasound-derived arterial endothelial function (endothelium-dependent dilation) of the brachial artery and intima-media thickness of common carotid artery. At 6 weeks, both interventions were associated with decreased waist-hip ratio (P<0.02) and cholesterol level (P<0.05) as well as improved arterial endothelial function. Diet and exercise together were associated with a significantly greater improvement in endothelial function than diet alone (P=0.01). At 1 year, there was significantly less thickening of the carotid wall (P<0.001) as well as persistent improvements in body fat content and lipid profiles in the group continuing an exercise program. Vascular function was significantly better in those children continuing exercise (n=22) compared with children who withdrew from the exercise program (n= 19) (P<0.05). Conclusions-Obesity-related vascular dysfunction in otherwise healthy young children is partially reversible with diet alone or particularly diet combined with exercise training at 6 weeks, with sustained improvements at 1 year in those persisting with diet plus regular exercise.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://circ.ahajournals.orgen_HK
dc.relation.ispartofCirculationen_HK
dc.rightsCirculation. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectAtherosclerosisen_HK
dc.subjectEndotheliumen_HK
dc.subjectExerciseen_HK
dc.subjectLifestyleen_HK
dc.subjectObesityen_HK
dc.titleEffects of Diet and Exercise on Obesity-Related Vascular Dysfunction in Childrenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-7322&volume=109&spage=1981&epage=1986&date=2004&atitle=Effects+of+diet+and+exercise+on+obesity-related+vascular+dysfunction+in+childrenen_HK
dc.identifier.emailYu, CW: yucw@hkucc.hku.hken_HK
dc.identifier.authorityYu, CW=rp00982en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1161/01.CIR.0000126599.47470.BEen_HK
dc.identifier.pmid15066949-
dc.identifier.scopuseid_2-s2.0-2142767317en_HK
dc.identifier.hkuros93697en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2142767317&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume109en_HK
dc.identifier.issue16en_HK
dc.identifier.spage1981en_HK
dc.identifier.epage1986en_HK
dc.identifier.isiWOS:000221054600015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWoo, KS=7202574149en_HK
dc.identifier.scopusauthoridChook, P=6603266983en_HK
dc.identifier.scopusauthoridYu, CW=35235958400en_HK
dc.identifier.scopusauthoridSung, RYT=7101684314en_HK
dc.identifier.scopusauthoridQiao, M=7006316387en_HK
dc.identifier.scopusauthoridLeung, SSF=7202044842en_HK
dc.identifier.scopusauthoridLam, CWK=8531362100en_HK
dc.identifier.scopusauthoridMetreweli, C=55397062200en_HK
dc.identifier.scopusauthoridCelermajer, DS=7005533405en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats