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Article: The association between seated immobility and local lower-limb venous coagulability in healthy adult volunteers: A simulation of prolonged travel immobility

TitleThe association between seated immobility and local lower-limb venous coagulability in healthy adult volunteers: A simulation of prolonged travel immobility
Authors
KeywordsCoagulability
Sitting
Thrombosis
Travel
Venous
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.bloodcoagulation.com
Citation
Blood Coagulation And Fibrinolysis, 2006, v. 17 n. 5, p. 335-341 How to Cite?
AbstractThis is the first study to examine the hypothesis that prolonged sitting is associated with procoagulant changes in the local lower-limb venous system. A comparison was made with upper-limb venous changes. Changes in markers of thrombin generation, fibrinolysis, endothelial perturbation and haemoconcentration were analysed as 10 healthy adult male participants sat for 8 h. The change in foot volume was estimated. Subjective venous thromboembolism assessment was undertaken hourly, along with 2-week and 4-week safety follow-up for clinical events.Expected increases in median prothrombin fragments 1 and 2, thrombin-antithrombin complex and D-dimer were not observed in either limb. An increase greater than 45% in the median tissue plasminogen activator and plasminogen activator-1 molar ratio (t-PA/PAI-1), and a decrease greater than 15% in median soluble thrombomodulin were noted in both limbs. Median haematocrit decreased minimally (1%) in the lower limbs, while the foot volume increased by 4%. Subjects experienced vague symptoms after 6 h of sitting, but none developed symptomatic venous thromboembolism. Upper and lower-limb changes in biomarkers did not correlate, except those in t-PA/PAI-1 ratio and plasminogen activator-1. Significant correlation was found between changes in the lower-limb t-PA/PAI-1 ratio and right foot volume.This study originally reveals that even in the lower limbs, prolonged daytime cramped sitting is not associated with significant procoagulant changes in healthy adult male volunteers, and confirms a previous observation that local lower-limb venous changes are not identically reflected in the upper limbs. © 2006 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/87664
ISSN
2015 Impact Factor: 1.242
2015 SCImago Journal Rankings: 0.496
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAnsari, MTen_HK
dc.contributor.authorMahmood, MTen_HK
dc.contributor.authorKarlberg, JPEen_HK
dc.date.accessioned2010-09-06T09:32:44Z-
dc.date.available2010-09-06T09:32:44Z-
dc.date.issued2006en_HK
dc.identifier.citationBlood Coagulation And Fibrinolysis, 2006, v. 17 n. 5, p. 335-341en_HK
dc.identifier.issn0957-5235en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87664-
dc.description.abstractThis is the first study to examine the hypothesis that prolonged sitting is associated with procoagulant changes in the local lower-limb venous system. A comparison was made with upper-limb venous changes. Changes in markers of thrombin generation, fibrinolysis, endothelial perturbation and haemoconcentration were analysed as 10 healthy adult male participants sat for 8 h. The change in foot volume was estimated. Subjective venous thromboembolism assessment was undertaken hourly, along with 2-week and 4-week safety follow-up for clinical events.Expected increases in median prothrombin fragments 1 and 2, thrombin-antithrombin complex and D-dimer were not observed in either limb. An increase greater than 45% in the median tissue plasminogen activator and plasminogen activator-1 molar ratio (t-PA/PAI-1), and a decrease greater than 15% in median soluble thrombomodulin were noted in both limbs. Median haematocrit decreased minimally (1%) in the lower limbs, while the foot volume increased by 4%. Subjects experienced vague symptoms after 6 h of sitting, but none developed symptomatic venous thromboembolism. Upper and lower-limb changes in biomarkers did not correlate, except those in t-PA/PAI-1 ratio and plasminogen activator-1. Significant correlation was found between changes in the lower-limb t-PA/PAI-1 ratio and right foot volume.This study originally reveals that even in the lower limbs, prolonged daytime cramped sitting is not associated with significant procoagulant changes in healthy adult male volunteers, and confirms a previous observation that local lower-limb venous changes are not identically reflected in the upper limbs. © 2006 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.bloodcoagulation.comen_HK
dc.relation.ispartofBlood Coagulation and Fibrinolysisen_HK
dc.rightsBlood Coagulation and Fibrinolysis. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subjectCoagulabilityen_HK
dc.subjectSittingen_HK
dc.subjectThrombosisen_HK
dc.subjectTravelen_HK
dc.subjectVenousen_HK
dc.titleThe association between seated immobility and local lower-limb venous coagulability in healthy adult volunteers: A simulation of prolonged travel immobilityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0957-5235&volume=17 &issue=5&spage=335&epage=341&date=2006&atitle=The+association+between+seated+immobility+and+local+lower-limb+venous+coagulability+in+healthy+adult+volunteers:+a+simulation+of+prolonged+travel+immobilityen_HK
dc.identifier.emailKarlberg, JPE: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, JPE=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.mbc.0000233362.80486.6cen_HK
dc.identifier.pmid16788308-
dc.identifier.scopuseid_2-s2.0-33745411226en_HK
dc.identifier.hkuros124734en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745411226&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue5en_HK
dc.identifier.spage335en_HK
dc.identifier.epage341en_HK
dc.identifier.isiWOS:000239231500001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAnsari, MT=8630124500en_HK
dc.identifier.scopusauthoridMahmood, MT=55331956900en_HK
dc.identifier.scopusauthoridKarlberg, JPE=7005218406en_HK

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