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Article: Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: A systematic review and meta-analysis

TitleNon-steroidal anti-inflammatory drug use and the risk of gastric cancer: A systematic review and meta-analysis
Authors
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://jncicancerspectrum.oxfordjournals.org/
Citation
Journal Of The National Cancer Institute, 2003, v. 95 n. 23, p. 1784-1791 How to Cite?
AbstractBackground: The relationship between the use of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin and the risk of gastric cancer has not been well studied. We performed a systematic review and meta-analysis of published studies to evaluate the association between use of this class of drugs and the risk of gastric cancer. Methods: A fully recursive literature search to January 2003 was conducted in MEDLINE, PubMed, and CANCERLIT to identify potentially relevant case-control or cohort studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under a random-effects model. Results: Nine studies (eight case-control and one cohort) with a total of 2831 gastric cancer case patients were identified. NSAID use was associated with a reduced risk of gastric cancer, with a summary odds ratio of 0.78 (95% CI = 0.69 to 0.87). Users of aspirin (OR = 0.73, 95% CI = 0.63 to 0.86) and non-aspirin NSAIDs (OR = 0.74, 95% CI = 0.55 to 1.00) experienced similar magnitudes of risk reduction. Regular users of NSAIDs (OR = 0.57, 95% CI = 0.44 to 0.74) experienced a lower risk of gastric cancer relative to nonusers than did irregular users (OR = 0.76, 95% CI = 0.62 to 0.94; P = .09 versus regular users). A stratified analysis showed that NSAID use was associated with a statistically significant reduction in risk of noncardia gastric cancer (OR = 0.72, 95% CI = 0.58 to 0.89), but not of gastric cancer at the cardia (OR = 0.80, 95% CI = 0.53 to 1.20). There was no evidence that study design or type of control subject substantially influenced the estimate of effects. Conclusion: NSAID use was associated with a decreased risk of gastric cancer in a dose-dependent manner. This finding warrants proper clinical trials in populations with high risk of gastric cancer.
Persistent Identifierhttp://hdl.handle.net/10722/87563
ISSN
2015 Impact Factor: 11.37
2015 SCImago Journal Rankings: 6.192
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, WHen_HK
dc.contributor.authorHuang, JQen_HK
dc.contributor.authorZheng, GFen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorKarlberg, Jen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-06T09:31:28Z-
dc.date.available2010-09-06T09:31:28Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of The National Cancer Institute, 2003, v. 95 n. 23, p. 1784-1791en_HK
dc.identifier.issn0027-8874en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87563-
dc.description.abstractBackground: The relationship between the use of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin and the risk of gastric cancer has not been well studied. We performed a systematic review and meta-analysis of published studies to evaluate the association between use of this class of drugs and the risk of gastric cancer. Methods: A fully recursive literature search to January 2003 was conducted in MEDLINE, PubMed, and CANCERLIT to identify potentially relevant case-control or cohort studies. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated under a random-effects model. Results: Nine studies (eight case-control and one cohort) with a total of 2831 gastric cancer case patients were identified. NSAID use was associated with a reduced risk of gastric cancer, with a summary odds ratio of 0.78 (95% CI = 0.69 to 0.87). Users of aspirin (OR = 0.73, 95% CI = 0.63 to 0.86) and non-aspirin NSAIDs (OR = 0.74, 95% CI = 0.55 to 1.00) experienced similar magnitudes of risk reduction. Regular users of NSAIDs (OR = 0.57, 95% CI = 0.44 to 0.74) experienced a lower risk of gastric cancer relative to nonusers than did irregular users (OR = 0.76, 95% CI = 0.62 to 0.94; P = .09 versus regular users). A stratified analysis showed that NSAID use was associated with a statistically significant reduction in risk of noncardia gastric cancer (OR = 0.72, 95% CI = 0.58 to 0.89), but not of gastric cancer at the cardia (OR = 0.80, 95% CI = 0.53 to 1.20). There was no evidence that study design or type of control subject substantially influenced the estimate of effects. Conclusion: NSAID use was associated with a decreased risk of gastric cancer in a dose-dependent manner. This finding warrants proper clinical trials in populations with high risk of gastric cancer.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jncicancerspectrum.oxfordjournals.org/en_HK
dc.relation.ispartofJournal of the National Cancer Instituteen_HK
dc.rightsJournal of the National Cancer Institute (Print). Copyright © Oxford University Press.en_HK
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - administration & dosage - pharmacologyen_HK
dc.subject.meshAnticarcinogenic Agents - administration & dosage - pharmacologyen_HK
dc.subject.meshCardiaen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshHelicobacter Infections - complicationsen_HK
dc.subject.meshHelicobacter pylorien_HK
dc.subject.meshHumansen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshResearch Designen_HK
dc.subject.meshRisk Assessmenten_HK
dc.subject.meshStomach Neoplasms - epidemiology - microbiology - prevention & controlen_HK
dc.titleNon-steroidal anti-inflammatory drug use and the risk of gastric cancer: A systematic review and meta-analysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-8874&volume=95&issue=23&spage=1784&epage=1791&date=2003&atitle=Non-Steroidal+Anti-Inflammatory+Drug+Use+and+the+Risk+of+Gastric+Cancer:+A+Systematic+Review+and+Meta-Analysisen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid14652240-
dc.identifier.scopuseid_2-s2.0-0346258154en_HK
dc.identifier.hkuros85350en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0346258154&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue23en_HK
dc.identifier.spage1784en_HK
dc.identifier.epage1791en_HK
dc.identifier.isiWOS:000187080700012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWang, WH=23390847100en_HK
dc.identifier.scopusauthoridHuang, JQ=7403635051en_HK
dc.identifier.scopusauthoridZheng, GF=7402224500en_HK
dc.identifier.scopusauthoridLam, SK=7402279800en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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