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Article: A randomized study comparing the use of sublingual to vaginal misoprostol for pre-operative cervical priming prior to surgical termination of pregnancy in the first trimester

TitleA randomized study comparing the use of sublingual to vaginal misoprostol for pre-operative cervical priming prior to surgical termination of pregnancy in the first trimester
Authors
KeywordsCervical priming
Misoprostol
Sublingual
Vaginal
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2004, v. 19 n. 5, p. 1101-1104 How to Cite?
AbstractBackground: Misoprostol is an effective agent for pre-operative cervical priming before surgical termination of pregnancy in the first trimester. Previous studies have shown that both oral and vaginal routes are equally effective for such a purpose. This study aimed to compare a new route of sublingual administration to the vaginal route of administration for pre-operative cervical priming in first trimester surgical abortion. Methods: Eighty women with gestational age <12 weeks were randomized by a computer-generated model to receive 400 μg of misoprostol either sublingually or vaginally 3 h prior to vacuum aspiration. The primary outcome measure was the degree of cervical dilatation, and secondary outcomes included the force required to dilate the cervix from 3 to 8 mm, intra-operative blood loss and incidence of pre-operative side-effects. Results: There was no significant difference in the baseline cervical dilatation (sublingual: 7.6 ± 1.3 mm; vaginal: 7.7 ± 0.73 mm), cumulative force required to dilate the cervix from 3 to 8 mm (sublingual: 9.0 ± 9.8 N; vaginal: 6.6 ± 5.4 N) and total blood loss (sublingual: 52.1 ± 20.2 ml; vaginal: 48.3 ± 12.3 ml). Pre-operative side-effects were also similar. Conclusions: Both sublingual and vaginal misoprostol are effective in cervical priming before surgical termination of pregnancy in the first trimester. Sublingual misoprostol has the advantage of being more convenient to administer and may be more suitable for day surgery. © European Society of Human Reproduction and Embryology 2004; all rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/87493
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, OSen_HK
dc.contributor.authorMok, KHen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:30:22Z-
dc.date.available2010-09-06T09:30:22Z-
dc.date.issued2004en_HK
dc.identifier.citationHuman Reproduction, 2004, v. 19 n. 5, p. 1101-1104en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87493-
dc.description.abstractBackground: Misoprostol is an effective agent for pre-operative cervical priming before surgical termination of pregnancy in the first trimester. Previous studies have shown that both oral and vaginal routes are equally effective for such a purpose. This study aimed to compare a new route of sublingual administration to the vaginal route of administration for pre-operative cervical priming in first trimester surgical abortion. Methods: Eighty women with gestational age <12 weeks were randomized by a computer-generated model to receive 400 μg of misoprostol either sublingually or vaginally 3 h prior to vacuum aspiration. The primary outcome measure was the degree of cervical dilatation, and secondary outcomes included the force required to dilate the cervix from 3 to 8 mm, intra-operative blood loss and incidence of pre-operative side-effects. Results: There was no significant difference in the baseline cervical dilatation (sublingual: 7.6 ± 1.3 mm; vaginal: 7.7 ± 0.73 mm), cumulative force required to dilate the cervix from 3 to 8 mm (sublingual: 9.0 ± 9.8 N; vaginal: 6.6 ± 5.4 N) and total blood loss (sublingual: 52.1 ± 20.2 ml; vaginal: 48.3 ± 12.3 ml). Pre-operative side-effects were also similar. Conclusions: Both sublingual and vaginal misoprostol are effective in cervical priming before surgical termination of pregnancy in the first trimester. Sublingual misoprostol has the advantage of being more convenient to administer and may be more suitable for day surgery. © European Society of Human Reproduction and Embryology 2004; all rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectCervical primingen_HK
dc.subjectMisoprostolen_HK
dc.subjectSublingualen_HK
dc.subjectVaginalen_HK
dc.titleA randomized study comparing the use of sublingual to vaginal misoprostol for pre-operative cervical priming prior to surgical termination of pregnancy in the first trimesteren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=19&issue=5&spage=1101&epage=1104&date=2004&atitle=A+randomized+study+comparing+the+use+of+sublingual+to+vaginal+misoprostol+for+pre-operative+cervical+priming+prior+to+surgical+termination+of+pregnancy+in+the+first+trimesteren_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/humrep/deh143en_HK
dc.identifier.pmid15070888-
dc.identifier.scopuseid_2-s2.0-2442591806en_HK
dc.identifier.hkuros87432en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2442591806&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1101en_HK
dc.identifier.epage1104en_HK
dc.identifier.isiWOS:000221143000015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTang, OS=7006723402en_HK
dc.identifier.scopusauthoridMok, KH=7103141156en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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