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Article: Pharmacokinetics of different routes of administration of misoprostol

TitlePharmacokinetics of different routes of administration of misoprostol
Authors
KeywordsMisoprostol
Oral
Pharmacokinetics
Sublingual
Vaginal
Issue Date2002
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2002, v. 17 n. 2, p. 332-336 How to Cite?
AbstractBackground: The pharmacokinetic parameters of four different routes of administration of a single dose of 400 μg of misoprostol were studied. Methods: A total of 40 women undergoing termination of pregnancy by suction evacuation was randomized by computer model to receive 400 μg of misoprostol by one of four routes: (i) sublingual (ii) oral (iii) vaginal and (iv) vaginal with addition of water. Venous blood samples were taken at 0, 1, 2, 5, 10, 20, 30, 45, 60, 120, 240 and 360 min after the administration of misoprostol. Misoprostol acid (MPA) was determined in serum samples using gas chromatography/tandem mass spectrometry. Results: Sublingual misoprostol achieved the highest serum peak concentration (Cmax) (574.8 ± 250.7 pg/ml) of MPA and this was significantly higher than those in the other groups [Oral: 287.6 ± 144.3 pg/ml (P < 0.01), vaginal: 125.2 ± 53.8 pg/ml (P < 0.001) and vaginal with water: 162.8 ± 57.1 pg/ml (P < 0.001)]. The time to peak concentration (Tmax) was similar in both the sublingual (26.0 ± 11.5 min) and oral groups (27.5 ± 14.8 min) and was significantly shorter than those in both vaginal groups. The area under the MPA concentration versus time curve up to 360 min in the sublingual group (743.7 ± 291.2 pg.h/ml) was significantly greater than those in oral (402.8 ± 151.6 pg.h/ml, P < 0.05) and vaginal (433.7 ± 182.6 pg.h/ml, P < 0.05) groups, but no significant difference was found between sublingual and vaginal administration if water (649.3 ± 333.8 pg.h/ml) was added. Conclusion: The new sublingual route of administration of misoprostol demonstrated a great potential to be developed into a method of medical abortion.
Persistent Identifierhttp://hdl.handle.net/10722/87491
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, OSen_HK
dc.contributor.authorSchweer, Hen_HK
dc.contributor.authorSeyberth, HWen_HK
dc.contributor.authorLee, SWHen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:30:20Z-
dc.date.available2010-09-06T09:30:20Z-
dc.date.issued2002en_HK
dc.identifier.citationHuman Reproduction, 2002, v. 17 n. 2, p. 332-336en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87491-
dc.description.abstractBackground: The pharmacokinetic parameters of four different routes of administration of a single dose of 400 μg of misoprostol were studied. Methods: A total of 40 women undergoing termination of pregnancy by suction evacuation was randomized by computer model to receive 400 μg of misoprostol by one of four routes: (i) sublingual (ii) oral (iii) vaginal and (iv) vaginal with addition of water. Venous blood samples were taken at 0, 1, 2, 5, 10, 20, 30, 45, 60, 120, 240 and 360 min after the administration of misoprostol. Misoprostol acid (MPA) was determined in serum samples using gas chromatography/tandem mass spectrometry. Results: Sublingual misoprostol achieved the highest serum peak concentration (Cmax) (574.8 ± 250.7 pg/ml) of MPA and this was significantly higher than those in the other groups [Oral: 287.6 ± 144.3 pg/ml (P < 0.01), vaginal: 125.2 ± 53.8 pg/ml (P < 0.001) and vaginal with water: 162.8 ± 57.1 pg/ml (P < 0.001)]. The time to peak concentration (Tmax) was similar in both the sublingual (26.0 ± 11.5 min) and oral groups (27.5 ± 14.8 min) and was significantly shorter than those in both vaginal groups. The area under the MPA concentration versus time curve up to 360 min in the sublingual group (743.7 ± 291.2 pg.h/ml) was significantly greater than those in oral (402.8 ± 151.6 pg.h/ml, P < 0.05) and vaginal (433.7 ± 182.6 pg.h/ml, P < 0.05) groups, but no significant difference was found between sublingual and vaginal administration if water (649.3 ± 333.8 pg.h/ml) was added. Conclusion: The new sublingual route of administration of misoprostol demonstrated a great potential to be developed into a method of medical abortion.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectMisoprostolen_HK
dc.subjectOralen_HK
dc.subjectPharmacokineticsen_HK
dc.subjectSublingualen_HK
dc.subjectVaginalen_HK
dc.titlePharmacokinetics of different routes of administration of misoprostolen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=17&issue=2&spage=332&epage=336&date=2002&atitle=Pharmacokinetics+of+different+routes+of+administration+of+misoprostolen_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11821273-
dc.identifier.scopuseid_2-s2.0-0036182991en_HK
dc.identifier.hkuros65454en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036182991&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue2en_HK
dc.identifier.spage332en_HK
dc.identifier.epage336en_HK
dc.identifier.isiWOS:000173908400014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTang, OS=7006723402en_HK
dc.identifier.scopusauthoridSchweer, H=7006657959en_HK
dc.identifier.scopusauthoridSeyberth, HW=35492907400en_HK
dc.identifier.scopusauthoridLee, SWH=26030998000en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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